Abstract:
:The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-lethal concentrations of methomyl (lower than 0.320 g L-1; i.e. below the estimated LC10) triggered significant changes on motor behavior and development impairment. The type of movement was significantly altered in methomyl-exposed worms, as well as biometric parameters (worms frequently idle and moving more backwards than controls; small body area, length and wavelength). These effects were followed by an increase of acetylcholine levels. Interestingly, after the 48-h recovery period, movement of previously exposed worms was similar to controls, and a concentration-dependent reversion of biometric endpoints was recorded, pointing out the transient action of the carbamate in line with an apparent absence of cholinergic neurons damage. This study provided new insight on the neurotoxicity of methomyl by showing that effects on movement and development were transient, and apparently did not result in neurodegeneration in cholinergic neurons. Moreover, these findings reinforced the advantages of using C. elegans in a multi-level approach for pesticide effects assessment.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Queirós L,Martins AC,Krum BN,Ke T,Aschner M,Pereira JL,Gonçalves FJM,Milne GL,Pereira Pdoi
10.1016/j.tox.2021.152684subject
Has Abstractpub_date
2021-01-25 00:00:00pages
152684eissn
0300-483Xissn
1879-3185pii
S0300-483X(21)00007-Xpub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90031-7
更新日期:1976-11-01 00:00:00
abstract::Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00416-9
更新日期:2001-05-28 00:00:00
abstract::It is generally believed that estrogen receptor-dependent and -independent pathways are involved in mediating the developmental effects of the synthetic estrogen, diethylstilbestrol (DES). However, the precise role and extent to which each pathway contributes to the resulting pathologies remains unknown. We have emplo...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2004.06.046
更新日期:2004-12-01 00:00:00
abstract::Our previous study revealed that exposure to 0.4 ppm ozone (O(3)) enhanced nasal allergy-like reactions in guinea pigs. In the present study, we investigated the concentration-dependency of the effects of exposure to O(3) on the aggravation of nasal allergy-like reactions induced by repeated nasal administration of an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.008
更新日期:2004-06-01 00:00:00
abstract::Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.01.001
更新日期:2011-03-15 00:00:00
abstract::The allergenicity of various compounds was tested by means of the optimization procedure in the guinea-pig. Results with antibiotics, preservatives, fragrance raw materials and miscellaneous contactants are reported. Their relevance is critically discussed in relation to other animal sensitization methods (Draize, Büh...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90050-5
更新日期:1980-01-01 00:00:00
abstract::High doses of cephaloridine produce necrosis of renal proximal tubular cells and this nephrotoxicity has been shown to be reduced by piperonyl butoxide (a mixed-function oxidase inhibitor) in rats and rabbits, and potentiated by phenobarbital (a mixed-function oxidase inducer) in rabbits but not rats. Phenobarbital is...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90011-7
更新日期:1982-01-01 00:00:00
abstract::Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.002
更新日期:2019-05-01 00:00:00
abstract::Fire creates a complex toxic environment involving flame, heat, oxygen depletion, smoke, and toxic gases. The nature of that environment is dependent upon not only the materials present but on the fire event, that is, the fire scenario. Materials have different toxic gas profiles under different conditions; therefore,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90167-3
更新日期:1987-12-01 00:00:00
abstract::Male Wistar rats were exposed to 200, 1000 or 2000 ppm of 1,1,2-trichloro-1,2,2-trifluoroethane vapor 5 days a week 6 h daily for 1 or 2 weeks. Proliferation and vacuolisation of the smooth endoplasmic reticulum (SER) of the liver was seen electron microscopically after 1 and 2 weeks in the rats exposed to 1000 and 20...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90034-7
更新日期:1980-01-01 00:00:00
abstract::Rats were injected i.p. with the organophosphate insecticide ABATE and tested over the next 16 days. Animals given 1000 mg/kg showed impaired performance of a previously conditioned avoidance response 6 days after injection but not 2, 8, 10, or 16 days after injection. No behavioral changes were observed in animals gi...
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42 in the lenses of UPL rats, which then leads to lens opacification. In add...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.08.003
更新日期:2014-01-06 00:00:00
abstract::Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03586-x
更新日期:1997-03-14 00:00:00
abstract::Experiments were done in vivo to determine the effect of oxygen at high pressure (OHP) on NAD+ and NADH in mouse brain cortex. A 7% decrease (N.S.) in NADH was found in brain cortex from mice exposed to 6 atm of 100% oxygen for 8 min, while a 20% decrease (P less than 0.01) in cortical NADH, when compared to controls,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90014-2
更新日期:1982-01-01 00:00:00
abstract::The effect of dose and duration of treatment with chromium on its distribution in certain vital organs and the blood of rats has been investigated. The accumulation of metal was highest in liver and kidneys, followed by testes, brain and blood and was rather more dependent on the dose than on the duration of exposure....
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Formaldehyde (FA) is an important substance that induces sick house syndrome and diseases, such as asthma and allergies. Oxidative stress is involved in the development of respiratory disease, and diverse antioxidants may protect respiratory tract cells from apoptosis. Peroxiredoxin is a pivotal endogenous antioxidant...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.03.011
更新日期:2010-05-27 00:00:00
abstract::This study was undertaken to investigate whether treatment with vitamin E (VE) and/or vitamin C (VC) protects rat sperm by inhibiting reactive oxygen species generation induced by lead (Pb) exposure. Male Sprague-Dawley rats were assigned to the following five groups: vitamin-unsupplemented; 150 mg VE/kg chow suppleme...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00068-7
更新日期:1998-07-17 00:00:00
abstract::The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00292-4
更新日期:2000-11-02 00:00:00
abstract:OBJECTIVE:This study was designed to investigate whether the mice treated with triptolide (TP) could disrupt the liver immune homeostasis, resulting in the inability of the liver to eliminate the harmful response induced by lipopolysaccharide (LPS). In addition, we explored whether apoptosis and necroptosis played a cr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.01.005
更新日期:2019-02-15 00:00:00
abstract::Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.01.017
更新日期:2015-04-01 00:00:00
abstract::Dimethoate, azinphos-methyl, diazinon and pirimiphos-methyl, widely used organophosphorous insecticides, and benomyl, a benzimidazole fungicide, induce different cytotoxic effects on the human leukemia cell line HL-60. Among the insecticides tested, only azinphos and diazinon induced a dose-related inhibition of prote...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90036-1
更新日期:1994-11-01 00:00:00
abstract::In the present work was analyzed whether sulforaphane (SFN) may protect against cisplatin (CIS)-induced hepatic damage, oxidant stress and mitochondrial dysfunction. Four groups of male Wistar rats were studied: control, CIS, CIS+SFN and SFN. SFN was given i.p. (500 μg/kg/d × 3 days) before CIS administration (single ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.04.014
更新日期:2011-08-15 00:00:00
abstract::Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.04.009
更新日期:2011-07-29 00:00:00
abstract::Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.004
更新日期:2019-04-01 00:00:00
abstract::N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90074-4
更新日期:1994-11-11 00:00:00
abstract::Silver nanoparticles (AgNPs) are widely utilized in various consumer products and medical devices, especially due to their antimicrobial properties. However, several studies have associated these particles with toxic effects, such as inflammation and oxidative stress in vivo and cytotoxic and genotoxic effects in vitr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.09.014
更新日期:2013-11-08 00:00:00
abstract::Arsenic contamination of drinking water is a matter of global concern. Arsenic intake impairs immune responses and leads to a variety of pathological conditions including cancer. In order to understand the intricate tuning of immune responses elicited by chronic exposure to arsenic, a mouse model was established by su...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.005
更新日期:2016-05-16 00:00:00
abstract::We have found that incubation of heparin plasma with Ni(2+) or Co(2+) at concentrations below 100 microM can stimulate the conversion of complement factor C3 to C3b faster than magnesium, which is the natural cofactor in the alternative complement activation. This conversion was monitored by light absorbance measureme...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00590-5
更新日期:2003-03-14 00:00:00
abstract::A clonal cell line, R40F, was selected from a heterogenous population of Cd2+ and Zn2+-resistant CHO-K1 cells. These R40F cells demonstrated resistance to 120- and 4-fold higher concentrations of Cd2+ and Zn2+, respectively, than did wild type CHO-K1 cells. When cultured in the presence of low concentrations of Cd2+ (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90088-4
更新日期:1983-03-01 00:00:00
abstract::Technical grade nitrofen was fed to 4 groups (25/group) of male Sprague-Dawley rats for 13 weeks at dietary concentrations of 0, 100, 500, or 2500 ppm. Untreated female rats of the same age and strain were mated with treated males and fertility, gestation, and lactation indices were monitored. After mating, males were...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90006-9
更新日期:1983-11-01 00:00:00