Abstract：
:BHK21 fibroblastic cells were exposed in vitro to lead microparticles produced by pyrolysis of the organic lead used as an antiknock agent in gasoline. Although non-cytolethal, 10 micrograms of lead/10(6) cells rapidly inhibited cell growth kinetics as well as [3H]thymidine and L-[3H]leucine incorporation by the BHK21 cell line. The growth rate inhibition provoked by chronic exposure to lead microparticles became reversible when the cells were cultured without the microparticulate pollutant. The cloning efficiency of BHK21 cells was impaired by lead concentrations above 1 mg/10(6) cells.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Dubreuil A,Hollande E,Bouley G,Boudene Csubject
Has Abstractpub_date
1979-08-01 00:00:00pages
249-62issue
3eissn
0300-483Xissn
1879-3185journal_volume
13pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90062-6
更新日期：1991-01-01 00:00:00
abstract：:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03230-d
更新日期：1995-12-28 00:00:00
abstract：:The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.05.012
更新日期：2010-09-10 00:00:00
abstract：:Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. More specifically, cardiac fibroblasts are activated by a variety of pathological stimuli, th...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.07.002
更新日期：2014-09-02 00:00:00
abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90056-m
更新日期：1990-06-01 00:00:00
abstract：:Both 4,4'-dichlorobiphenyl (4,4'-DCB) and 3-methylcholanthrene (3-MC) caused a substantial increase of phenacetin-induced hepatic glutathione (GSH) depletion, whereas phenobarbital (PB) had no effect, suggesting that 4,4'-DCB possesses cytochrome P-448 inducing activity. The O-deethylation of phenacetin by liver micro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90014-4
更新日期：1986-12-15 00:00:00
abstract：:Stannous chloride (SnCl2) is a reducing chemical agent used in several man-made products. SnCl2 can generate reactive oxygen species (ROS). Therefore, the present study has been carried out to investigate the antioxidant action of l-ascorbic acid (AA) in minimizing SnCl2 toxicity on lipid peroxidation, antioxidant enz...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.03.017
更新日期：2007-06-25 00:00:00
abstract：:Natural phytochemicals derived from dietary sources or medicinal plants have gained significant recognition in the potential management of several human clinical conditions. Much research has also been geared towards the evaluation of plant extracts as effective prophylactic agents since they can act on specific and/o...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.10.010
更新日期：2010-12-05 00:00:00
abstract：:Recently, chimeric mice with humanized liver were established by transplanting human hepatocytes into an urokinase-type plasminogen activator(+/+)/severe combined immunodeficient transgenic mouse line. The replacement with human hepatocytes is more than 80-90% and is higher than any other chimeric mouse reported previ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2007.11.012
更新日期：2008-04-03 00:00:00
abstract：:Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90173-8
更新日期：1985-03-15 00:00:00
abstract：:Organophosphates and pyrethroids are among the most common pesticides currently in use worldwide. Several pesticides have been reported to possess hormonal activities, and thus are classified as endocrine disruptors. The present study was planned to evaluate potential androgenic and antiandrogenic activities of the pe...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.09.028
更新日期：2008-01-14 00:00:00
abstract：:Both catecholamine (CA) released from adrenal chromaffin cells and hydrogen sulfide (H2S) have been shown to play critical roles in the regulation of hypoxic stress response. Our previous study has demonstrated that exogenous H2S directly induced quantal CA released from adult rat adrenal chromaffin cells (ARACCs) by ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.06.014
更新日期：2013-10-04 00:00:00
abstract：:Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pathway was involved in BPA-induced Sertoli cells injury via t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.06.001
更新日期：2014-10-03 00:00:00
abstract：OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.09.014
更新日期：2006-01-20 00:00:00
abstract：:Neonatal rat hearts were separated into separate cultures of beating myocytes (M cells), endothelial cells (E cells) and fibroblasts (F cells). Their susceptibilities to the toxic effects of emetine, chloroquine and metronidazole were then compared using a quantitative metabolic inhibition test (QMIT) and morphologic ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90066-0
更新日期：1984-11-01 00:00:00
abstract：:Relative cytotoxicity and mechanism of action of thiophenes were investigated in suspensions of freshly isolated renal proximal tubular (PT) and distal tubular (DT) cells using 4-(2-thienyl)butyric acid (TByA) as a model compound. TByA produced significantly greater time- and concentration-dependent cytotoxicity, as a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(95)03137-5
更新日期：1995-12-10 00:00:00
abstract：:Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.01.017
更新日期：2015-04-01 00:00:00
abstract：:The involvement of metallothionein (MT) in the nephrotoxicity of cis-diamminedichloroplatinum (c-DDP) was investigated in rats using enzyme excretion and histology as indicators of renal damage. In addition, the effects of renal glutathione (GSH) depletion on the nephrotoxicity of c-DDP was assessed by organic anion t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90129-5
更新日期：1990-11-01 00:00:00
abstract：:Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.12.006
更新日期：2018-02-01 00:00:00
abstract：:Antagonistic toxic effects of selenium and lead were studied in growing rats. Chronic lead intoxication was produced by cutaneous application of lead naphthenate solution (80-200 mg Pb/kg body weight) for a period of 8 weeks and chronic selenium intoxication was induced by giving 5 ppm, 10 ppm and 15 ppm selenium in d...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(76)90041-x
更新日期：1976-11-01 00:00:00
abstract：:To further investigate the immunotoxic effects of tri-n-propyltin chloride (TPTC), tri-n-butyltin chloride (TBTC) and triphenyltin chloride (TPhTC) several cytotoxicity tests with a series of trialkyltin chlorides and TPhTC were carried out, using isolated rat thymocytes as target cells. Thymocytes, cultured in a seru...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90160-5
更新日期：1986-04-01 00:00:00
abstract：:Ketamine, an anaesthetic agent used in newborns and toddlers, has been shown to induce neurodegeneration and alter adult behavior in mice, when administered during the neonatal period. Mammals have a marked period of rapid brain growth and development (BGS), which is postnatal in mice and rats, spanning the first 3-4 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.04.019
更新日期：2008-07-30 00:00:00
abstract：:The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90119-3
更新日期：1987-07-01 00:00:00
abstract：:Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP). PP include chemicals that activate different subtypes of the peroxisome proliferator-activated receptor (PPAR) family. The ability of phthalate esters and their metabolites to activate responses through different PPAR subtype...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.09.008
更新日期：2005-02-01 00:00:00
abstract：:Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS)....
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00159-1
更新日期：2000-04-20 00:00:00
abstract：:The effects of xenobiotic drugs and toxic compounds depend largely on their kinetic properties, which can be influenced by transmembrane drug transporters like MDR1/P-glycoprotein and the drug-conjugate transporters multidrug resistance protein (MRP) 1 and 2. As the dog is a preferential species used in the pharmacolo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00354-1
更新日期：2001-01-02 00:00:00
abstract：:4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names "Venus", "Bromo", "Erox", "XTC" or "Nexus". Concern has been raised because only little is known about its toxicity and metabolism in humans. In the present study we incubated 2C-B with human, monkey...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.07.004
更新日期：2005-01-05 00:00:00
abstract：:Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mou...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152683
更新日期：2021-01-19 00:00:00
abstract：UNLABELLED:National surveys of United States households and child care centers have demonstrated that pyrethroids are widely distributed in indoor habited dwellings and this suggests that co-exposure to multiple pyrethroids occurs in nonoccupational settings. The purpose of this research was to use an environmentally r...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.02.016
更新日期：2014-06-05 00:00:00
abstract：:The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of met...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90094-6
更新日期：1986-12-01 00:00:00
