Abstract：
:Utah Valley has provided an interesting and unique opportunity to evaluate the health effects of respirable particulate air pollution (PM10). Residents of this valley are predominantly nonsmoking members of the Church of Jesus Christ of Latter-day Saints (Mormons). The area has moderately high average PM10 levels with periods of highly elevated PM10 concentrations due to local emissions being trapped in a stagnant air mass near the valley floor during low-level temperature inversion episodes. Due to a labor dispute, there was intermittent operation of the single largest pollution source, an old integrated steel mill. Levels of other common pollutants including sulfur dioxide, ozone, and acidic aerosol are relatively low. Studies specific to Utah Valley have observed that elevated PM10 concentrations are associated with: (1) decreased lung function; (2) increased incidence of respiratory symptoms; (3) increased school absenteeism; (4) increased respiratory hospital admissions; and (5) increased mortality, especially respiratory and cardiovascular mortality.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Pope CA 3rddoi
10.1016/0300-483x(96)03372-0subject
Has Abstractpub_date
1996-07-17 00:00:00pages
149-55issue
1-3eissn
0300-483Xissn
1879-3185pii
0300-483X(96)03372-0journal_volume
111pub_type
杂志文章,评审相关文献
TOXICOLOGY文献大全abstract：:Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we prese...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2018.11.008
更新日期：2019-01-15 00:00:00
abstract：:For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.08.010
更新日期：2015-06-05 00:00:00
abstract：:The potential of single, toxic doses of fenitrothion (O,O-dimethyl O-(4-nitro-m-tolyl)phosphorothioate) to elicit delayed neurotoxicity in the adult White Leghorn hen was compared to the effects produced following similar treatment with the known neurotoxin, tri-o-tolyl phosphate (TOTP). Hens (2.0-2.5 kg body wt) rece...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90185-x
更新日期：1986-11-01 00:00:00
abstract：:Spores of actinomycetes, mesophilic gram-positive bacteria, isolated from moldy houses, induced the expression of inducible NO-synthase (iNOS) with a subsequent NO-production in RAW264.7 macrophages. No differences were detected between production of nitric oxide (NO) by alive or irradiated spores of different strains...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00141-8
更新日期：1997-12-26 00:00:00
abstract：:Chlordecone (CD) impairs biliary excretion of organic anions (including phenolphthalein glucuronide (PG), imipramine polar metabolites, and taurocholate) without evidence of hepatocellular necrosis in rats. In this study we investigated the hypothesis that CD-induced hepatobiliary dysfunction is dependent on CD concen...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90057-4
更新日期：1994-01-26 00:00:00
abstract：:In the clinical setting, antidotes are generally administered after the occurrence of a drug overdose. Therefore, the most pertinent evaluation of any new agent should model human exposure. This study tested whether acetaminophen (APAP) hepatotoxicity was reversed when S-adenosyl-L-methionine (SAMe) was administered a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.10.027
更新日期：2008-02-03 00:00:00
abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00452-8
更新日期：2001-11-30 00:00:00
abstract：:Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity may vary widely with species and strain, we examined the effect of te...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03544-5
更新日期：1997-01-15 00:00:00
abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90074-4
更新日期：1994-11-11 00:00:00
abstract：:p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-n...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00161-6
更新日期：2003-08-28 00:00:00
abstract：:Multidrug resistance type 1 P-glycoproteins (P-gp) and multidrug resistance associated proteins (MRP) were studied in differentiated primary human lung cells in culture, in comparison with permanent human lung cell lines and primary alveolar type II cells from rat lung. AII cells exhibited low basal levels of mdr1b mR...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00458-9
更新日期：2001-10-05 00:00:00
abstract：:Arsenicals are known to induce ROS, which can lead to DNA damage, oxidative stress, and carcinogenesis. A human urothelial cell line, UROtsa, was used to study the effects of arsenicals on the human bladder. Arsenite [As(III)] and monomethylarsonous acid [MMA(III)] induce oxidative stress in UROtsa cells after exposur...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.05.018
更新日期：2008-08-19 00:00:00
abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00372-9
更新日期：2001-06-21 00:00:00
abstract：:Both catecholamine (CA) released from adrenal chromaffin cells and hydrogen sulfide (H2S) have been shown to play critical roles in the regulation of hypoxic stress response. Our previous study has demonstrated that exogenous H2S directly induced quantal CA released from adult rat adrenal chromaffin cells (ARACCs) by ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.06.014
更新日期：2013-10-04 00:00:00
abstract：:Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2004.11.027
更新日期：2005-03-15 00:00:00
abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.10.002
更新日期：2016-09-14 00:00:00
abstract：:The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90133-3
更新日期：1988-11-30 00:00:00
abstract：:It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and nitromethane. Aldo-keto reductases (AKRs) are enz...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.11.022
更新日期：2008-02-28 00:00:00
abstract：:Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42 in the lenses of UPL rats, which then leads to lens opacification. In add...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.08.003
更新日期：2014-01-06 00:00:00
abstract：:L-695,256 is a novel 2-fluorenonyl carbapenem antibiotic with significant antimicrobial activity against strains of methicillin-resistant Staphylococci. This prototype compound was administered intravenously to rhesus monkeys (Macaca mulatta) at does of 50 or 200 mg/kg/day for 2 weeks to assess toxicity and found to i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03305-7
更新日期：1996-04-30 00:00:00
abstract：:Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that s...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.07.013
更新日期：2017-11-01 00:00:00
abstract：:Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00076-0
更新日期：1997-09-26 00:00:00
abstract：BACKGROUND:Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.01.012
更新日期：2019-03-15 00:00:00
abstract：:The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90050-o
更新日期：1992-01-01 00:00:00
abstract：:Cell detachment and cloning efficiency of Baby Hamster Kidney cells (BHK-21 C13) were used as parameters to quantify cytotoxicity in vitro of 3 endogenous chemicals (glutathione, L-methionine, L-cysteine HCl) and 4 organotin compounds (tributyltinoxide, tributyltinchloride, tetrabutyltin, tetraphenyltin). IC50 values ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90084-1
更新日期：1982-01-01 00:00:00
abstract：:Cruciferous vegetable consumption correlates with reduced risk of cancer. This chemopreventative activity may involve glucosinolates and their hydrolysis products. Glucosinolate-derived isothiocyanates have been studied for their toxicity and chemopreventative properties, but other hydrolysis products (epithionitriles...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.06.002
更新日期：2015-08-06 00:00:00
abstract：:Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152542
更新日期：2020-09-01 00:00:00
abstract：:A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90074-3
更新日期：1993-06-04 00:00:00
abstract：:Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.07.010
更新日期：2010-10-09 00:00:00
abstract：:V79 Chinese hamster cells are being genetically engineered for stable expression of cytochromes P450 using a SV40 early promoter containing plasmid as the eukaryotic expression vector. V79 cells lack endogenous cytochrome P450 activity. Therefore, genetically engineered V79 cell lines are defined for the cytochrome P4...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(93)90063-x
更新日期：1993-10-05 00:00:00
