Abstract:
:The tissue uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in a mouse model using the common human virus Coxsackievirus B3 (CB3), adapted here to the mouse. Male A/J-mice were infected with the CB3 virus and subsequently, on days 4 and 7 of the infection, injected with 0.5 microCi [14C]TCDD (about 65 micrograms/kg). An uninfected group was injected with [14C]TCDD and served as the control group. Spleen, thymus, heart, pancreas, liver and brain were dissected 24 h after isotope injection, and the [14C]TCDD content of the tissues was determined by standard liquid scintillation techniques. On day 7, whole body autoradiography was also performed, 4 h after the isotope injection. Our results clearly show that there is an increased TCDD uptake in the selected tissues during the CB3 infection and that this increased uptake is most pronounced on day 4 post inoculation, which corresponds to the peak of viraemia. It was found that the total tissue concentrations of TCDD were significantly increased on day 4 in the brain, pancreas, heart, spleen and liver. In the spleen, heart and brain they were still significantly increased on day 7. The considerable metabolic and immunological changes that generally are caused by infections might explain the change in accumulation of TCDD. It is possible that the increased uptake of TCDD affects the immune cells involved in repair of inflammatory tissue lesions, thereby affecting the progression of the disease.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Funseth E,Ilbäck NGdoi
10.1016/0300-483x(94)90202-xsubject
Has Abstractpub_date
1994-05-31 00:00:00pages
29-38issue
1-2eissn
0300-483Xissn
1879-3185pii
0300-483X(94)90202-Xjournal_volume
90pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.05.012
更新日期:2009-07-28 00:00:00
abstract::Ghrelin stimulates growth hormone (GH) release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in several cell types but the precise underlying protective mechanisms in pancreatic beta cells are poorly understood. Therefore, we investigated which pathway was related...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.013
更新日期:2007-07-31 00:00:00
abstract::Quantum dots (QDs) are potentially beneficial semi-conductor nanocrystals for use in diagnostics and therapeutics. The chemical composition of QDs however, has raised concerns as to their potential toxicity. Although a thorough examination using specific biochemical endpoints is necessary to assess QD toxicity, an und...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.05.006
更新日期:2011-08-15 00:00:00
abstract::Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 kn...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.07.004
更新日期:2017-08-15 00:00:00
abstract::Different affinities of blood for CO were observed in in vivo and in vitro experiments. Hamsters showed the greatest relative affinity (1.0), the corresponding value for rats was 0.8, for pigs 0.74 and for rabbits 0.58. The upward shift of the saturation curves was dependent on the rate of respiratory exchange per uni...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90031-1
更新日期:1975-01-01 00:00:00
abstract::We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone fo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.06.047
更新日期:2004-11-01 00:00:00
abstract::Several nitrocompounds have been screened for carcinogenicity in rodents, but this is a lengthy and expensive process, taking two years and typically costing 2.5 million dollars, and uses large numbers of animals. There is, therefore, much impetus to develop suitable alternative methods. One possible way of predicting...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.11.024
更新日期:2006-03-01 00:00:00
abstract::The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90050-o
更新日期:1992-01-01 00:00:00
abstract::Deoxynivalenol (DON) is one of the major mycotoxic contaminants of grains, which causes reduced weight gain in pigs. The cytotoxicity of DON to porcine hepatocytes was examined in this study. DON was added at the final concentration of 100, 10, 1, 0.1 or 0.01 microg/ml to the medium of primary cultured hepatocytes. Ce...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.07.001
更新日期:2004-11-15 00:00:00
abstract::The agricultural fungicide, N-(3,5-dichlorophenyl)succinimide (NDPS) induces acute polyuric renal failure which is attenuated by pretreatment with the glutathione depletors, diethyl maleate or buthionine sulfoximine (BSO). In the present study, the temporal aspects of BSO attenuation of NDPS nephrotoxicity were invest...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03581-0
更新日期:1997-02-28 00:00:00
abstract:UNLABELLED:National surveys of United States households and child care centers have demonstrated that pyrethroids are widely distributed in indoor habited dwellings and this suggests that co-exposure to multiple pyrethroids occurs in nonoccupational settings. The purpose of this research was to use an environmentally r...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.02.016
更新日期:2014-06-05 00:00:00
abstract::Studies on the pulmonary retention of benzo[a]pyrene after inhalation have shown that clearance is biphasic, with one component clearing with a half-time greater than 1 day and another with a half-time less than 1 day. In the work reported here we demonstrated that the amount of benzo[a]pyrene instilled in the lungs c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90066-6
更新日期:1985-06-28 00:00:00
abstract::In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00230-5
更新日期:2002-09-16 00:00:00
abstract::Male Wistar rats were exposed to 200, 1000 or 2000 ppm of 1,1,2-trichloro-1,2,2-trifluoroethane vapor 5 days a week 6 h daily for 1 or 2 weeks. Proliferation and vacuolisation of the smooth endoplasmic reticulum (SER) of the liver was seen electron microscopically after 1 and 2 weeks in the rats exposed to 1000 and 20...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90034-7
更新日期:1980-01-01 00:00:00
abstract::Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2003.11.005
更新日期:2004-03-01 00:00:00
abstract::Rats were exposed to 1.5 +/- 0.1 mg ozone/m3 for 4 days and the activities of glucose-6-P dehydrogenase (G6PDH), glutathione reductase (GR) and glutathione peroxidase (GSHPx) were measured in the cytosolic fraction of lungs from exposed and control rats. Enzyme activities were also measured in isolated alveolar macrop...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90083-6
更新日期:1985-12-01 00:00:00
abstract::The scandal of melamine-contamination has not been quite blown out, since the toxicity of melamine continues to raise concerns for public health. It has been well known that fetus and infant periods play the most important roles in brain development, whereas little has been done on the harmful effects of melamine on t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.08.011
更新日期:2011-11-18 00:00:00
abstract::A CYP3A4 promoter-reporter gene construct has been used to assess the ability of 16 known (in vivo) and putative (in vitro) inducers to transactivate a CYP3A4 reporter gene in HepG2 cells. With the exception of pravastatin, the remaining 15 compounds transactivated the CYP3A4 reporter gene with differing inductive abi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00281-0
更新日期:2002-12-27 00:00:00
abstract::In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00101-7
更新日期:1997-10-19 00:00:00
abstract::Adverse drug reactions (ADR) are common and many are thought to have a genetic predisposition. There has been a great deal of interest in the role of P450 enzyme gene polymorphisms in the pathogenesis of adverse reactions. The major impact to date of polymorphic P450 expression has been on pre-clinical drug developmen...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00247-6
更新日期:2003-10-01 00:00:00
abstract::The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00267-1
更新日期:2003-12-01 00:00:00
abstract::The effect of dose and duration of treatment with chromium on its distribution in certain vital organs and the blood of rats has been investigated. The accumulation of metal was highest in liver and kidneys, followed by testes, brain and blood and was rather more dependent on the dose than on the duration of exposure....
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::The use of colchicine-specific Fab fragments is of interest in human poisoning. In the present study, we show the efficacy of Fab fragments in reversing colchicine toxicity in mice. High affinity antibodies (Ka = 2 x 10(10) M-1) against colchicine were raised in goats; Fab fragments were purified by DEAE chromatograph...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90015-s
更新日期:1991-01-01 00:00:00
abstract::An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90117-1
更新日期:1975-11-01 00:00:00
abstract::Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.10.002
更新日期:2017-12-01 00:00:00
abstract::The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90042-8
更新日期:1984-12-01 00:00:00
abstract::Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90062-6
更新日期:1991-01-01 00:00:00
abstract::Oral administration of sodium pyridinethione together with 63Ni2+, 109Cd2+ or 65Zn2+ to non-pregnant mice resulted in very markedly increased levels of the metals in several tissues in comparison with animals given the metals alone. For 63Ni2+ the sodium pyridinethione induced a strong labelling of the pancreatic isle...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90148-4
更新日期:1986-03-01 00:00:00
abstract::The effects of xenobiotic drugs and toxic compounds depend largely on their kinetic properties, which can be influenced by transmembrane drug transporters like MDR1/P-glycoprotein and the drug-conjugate transporters multidrug resistance protein (MRP) 1 and 2. As the dog is a preferential species used in the pharmacolo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00354-1
更新日期:2001-01-02 00:00:00
abstract::Tetrahydrocannabinol (THC), a psychoactive component of marijuana, is known to exert cytotoxicity in immune cells. In the present study, we examined the cytotoxicity of Δ⁸-THC in mouse macrophage J774-1 cells and a possible involvement of cannabinoid receptors and stress-responsive mitogen-activated protein kinases (M...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.10.007
更新日期:2013-12-15 00:00:00