Abstract：
:Ghrelin stimulates growth hormone (GH) release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in several cell types but the precise underlying protective mechanisms in pancreatic beta cells are poorly understood. Therefore, we investigated which pathway was related with its anti-apoptotic effect in pancreatic beta cells. Exposure of HIT-T15 cells to ghrelin caused a rapid activation of MAPKs and Akt. Chemical inhibitors of MAPK and PI3K blocked the anti-apoptotic of ghrelin. Ghrelin also stimulated the mitochondrial pathways of apoptosis and it showed increased Bcl-2, decreased Bax, prevention cytochrome c release and inhibition of caspase-3 activation in pancreatic beta cell line HIT-T15. Our findings suggest that ghrelin may act as a survival factor that inhibits the apoptotics pathways, and the MAPKs, AKT pathways could be key roles in the apoptosis of pancreatic beta cells.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Zhang Y,Ying B,Shi L,Fan H,Yang D,Xu D,Wei Y,Hu X,Zhang Y,Zhang X,Wang T,Liu D,Dou L,Chen G,Jiang F,Wen Fdoi
10.1016/j.tox.2007.05.013subject
Has Abstractpub_date
2007-07-31 00:00:00pages
194-202issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00295-8journal_volume
237pub_type
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