Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis.

abstract：:The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices o...

journal_title：Toxicology

authors： Gurer-Orhan H,Sabir HU,Ozgüneş H

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND/AIMS:Liver fibrosis has been reported to be inhibited in vivo by oleanolic and ursolic acids. However, the mechanisms of the action of those triterpenoids are poorly understood. In this study, we aimed to determine the antifibrotic potential of other triterpenes, betulin and betulinic acid, and to characteri...

journal_title：Toxicology

authors： Szuster-Ciesielska A,Plewka K,Daniluk J,Kandefer-Szerszeń M

更新日期：2011-02-27 00:00:00

abstract：:Natural antioxidants like catechin are now known to have a modulatory role on physiological functions and biotransformation reactions involved in the detoxification process, thereby affording protection from toxic metabolic actions of xenobiotics. Reactive oxygen intermediates have been demonstrated to play an etiolog...

journal_title：Toxicology

authors： Parvez S,Tabassum H,Rehman H,Banerjee BD,Athar M,Raisuddin S

更新日期：2006-08-15 00:00:00

abstract：:An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was ...

journal_title：Toxicology

authors： Meyer O,Hansen EV

更新日期：1975-11-01 00:00:00

abstract：:The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...

journal_title：Toxicology

authors： Vaas S,Kreft L,Schwarz M,Braeuning A

更新日期：2014-11-05 00:00:00

abstract：:To investigate the mechanism of hepatocarcinogenesis due to dicyclanil (DC), an insect growth regulator for sheep, histopathological and molecular biological analyses were performed in the liver of male ICR mice fed on a diet containing 1500 ppm of DC for 2 weeks (Experiment I; Exp. I). In gene expression analyses usi...

journal_title：Toxicology

authors： Moto M,Okamura M,Muto T,Kashida Y,Machida N,Mistumori K

更新日期：2005-02-28 00:00:00

abstract：:Exposure of rats to 0.1 and 0.5 mg Cd/kg subcutaneously (s.c.) thrice weekly for 5 weeks resulted in an accumulation of cadmium in the liver in concentrations of 40 and 95 micrograms/g tissue, respectively, and a microsomal burden of Cd amounting to approx. 2-3% of the retained cadmium. The cytoplasm contained about 8...

journal_title：Toxicology

authors： Klimczak J,Wiśniewska-Knypl JM,Kolakowski J

更新日期：1984-09-14 00:00:00

abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...

journal_title：Toxicology

authors： Cagen SZ,MacDonald RL,Van Gelder G

更新日期：1996-10-28 00:00:00

abstract：:Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...

journal_title：Toxicology

authors： Namgyal D,Ali S,Mehta R,Sarwat M

更新日期：2020-09-01 00:00:00

abstract：:Gender is a factor that influences susceptibility of individuals to drug-induced liver injury in experimental animals and humans. In this study, we investigated the mechanisms underlying resistance of female mice to acetaminophen (APAP)-induced hepatotoxicity. Overnight-fasted male and female CD-1 mice were administer...

journal_title：Toxicology

authors： Masubuchi Y,Nakayama J,Watanabe Y

更新日期：2011-09-05 00:00:00

abstract：:In the clinical setting, antidotes are generally administered after the occurrence of a drug overdose. Therefore, the most pertinent evaluation of any new agent should model human exposure. This study tested whether acetaminophen (APAP) hepatotoxicity was reversed when S-adenosyl-L-methionine (SAMe) was administered a...

journal_title：Toxicology

authors： Terneus MV,Brown JM,Carpenter AB,Valentovic MA

更新日期：2008-02-03 00:00:00

abstract：:Antimony compounds are widely used in various manufacturing and semiconducting industries. Previously, it has been shown that antimony trichloride (SbCl3) elevates sister chromatid exchange (SCE) rates in V79 cells after a 28-h incubation. However, only limited data on its genotoxic effects are available so far. The p...

journal_title：Toxicology

authors： Huang H,Shu SC,Shih JH,Kuo CJ,Chiu ID

更新日期：1998-08-21 00:00:00

abstract：:The Salmonella mutagenicity assay was utilized to compare hepatic S9 fractions derived from wild and laboratory reared woodchucks (Marmota monax). Two promutagens, 7,12-dimethylbenz[a]anthracence (DMBA) and 2-amino-fluorene (AF) were tested at 5 concentrations with the tester strains TA98 and TA100, against 2 levels o...

journal_title：Toxicology

authors： Rashid KA,Babish JG,Mumma RO

更新日期：1988-01-01 00:00:00

abstract：:The possible juvenilizing effects of Dimilin and Altosid against larvae of Culex pipiens L. were studied. Apart from delayed lethal action, possible effect on the mean number of basal follicles developed per female has been considered. A baseline exposure was found which caused only low mortalities of the early 4th la...

journal_title：Toxicology

authors： Gaaboub IA,Rawash IA,El-Gayar FH,Traboulsi AF

更新日期：1981-01-01 00:00:00

abstract：:Methoxy-, ethoxy- and n-butoxy acetic acids, known urinary metabolites of the corresponding alkoxyethanol solvents, were administered by gavage to rats as a single oral dose equimolar with 500, 250 or 100 mg 2-methoxyethanol/kg body weight. Testicular weight and morphology were monitored over a 14-day period post-trea...

journal_title：Toxicology

authors： Foster PM,Lloyd SC,Blackburn DM

更新日期：1987-01-01 00:00:00

abstract：:National and international law is an essential component of the array of measures serving to protect against the hostile release of biological or chemical agents, and to help to mitigate the consequences should such a release nevertheless take place. These includes the Geneva Protocol of 1925, the Chemical Weapons Con...

journal_title：Toxicology

authors： Kenyon IR,Gutschmidt K,Cosivi O

更新日期：2005-10-30 00:00:00

abstract：:Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...

journal_title：Toxicology

authors： Zeng Q,Yi H,Huang L,An Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...

journal_title：Toxicology

authors： Mast TJ,Cukierski MA,Nau H,Hendrickx AG

更新日期：1986-05-01 00:00:00

abstract：:The brominated flame retardants tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD) are found in the environment, e.g., in sediments and organisms, in food items, human blood samples and mother's milk. In this study, the effects of both compounds on rat hepatic cytochrome P450 (CYP) levels and activities w...

journal_title：Toxicology

authors： Germer S,Piersma AH,van der Ven L,Kamyschnikow A,Fery Y,Schmitz HJ,Schrenk D

更新日期：2006-02-01 00:00:00

abstract：:Cyclophosphamide (CP) is a known immunomodulating agent. When presented to either late stage chick embryos (e.g. 18 days of incubation (DI] or neonatal chicks. CP induces selective B cell damage resulting in humoral immunosuppression in chickens. The present study was undertaken in order to provide further insights in...

journal_title：Toxicology

authors： Misra RR,Bloom SE

更新日期：1991-03-11 00:00:00

abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...

journal_title：Toxicology

authors： Gorman D,Drewry A,Huang YL,Sames C

更新日期：2003-05-01 00:00:00

abstract：:The human keratinocyte cell line, RHEK-1, was used to evaluate the cytotoxicity of benzoyl peroxide (BZP). As determined with the neutral red (NR) cytotoxicity assay, the 24-h midpoint (NR50) toxicity values, in mM, were 0.11 for BZP and 29.5 for benzoic acid, the stable metabolite of BZP. Irreversible cytotoxicity oc...

journal_title：Toxicology

authors： Babich H,Zuckerbraun HL,Wurzburger BJ,Rubin YL,Borenfreund E,Blau L

更新日期：1996-01-08 00:00:00

abstract：:The nonsteroidal anti-inflammatory drug (NSAID) diclofenac (DF) is associated with idiosyncratic hepatotoxicity and several other distinct hypersensitivity reactions. The mechanism(s) are unknown but evidence suggests both cell-mediated and antibody-mediated immune effector systems may be involved. In the present stud...

journal_title：Toxicology

authors： Gutting BW,Updyke LW,Amacher DE

更新日期：2002-04-02 00:00:00

abstract：:Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and ...

journal_title：Toxicology

authors： Meyer JN,Leuthner TC,Luz AL

更新日期：2017-11-01 00:00:00

abstract：:Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...

journal_title：Toxicology

authors： Guangwei X,Rongzhu L,Wenrong X,Suhua W,Xiaowu Z,Shizhong W,Ye Z,Aschner M,Kulkarni SK,Bishnoi M

更新日期：2010-01-12 00:00:00

abstract：:There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...

journal_title：Toxicology

authors： Tomita M,Katsuyama H,Watanabe Y,Okuyama T,Fushimi S,Ishikawa T,Nata M,Miyamoto O

更新日期：2014-05-07 00:00:00

abstract：:Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...

journal_title：Toxicology

authors： Dorman DC,Miller KL,D'Antonio A,James RA,Morgan KT

更新日期：1997-09-26 00:00:00

abstract：:The 24-h and 72-h incorporation of 59Fe into circulating erythrocytes in mice were strongly inhibited by a single subcutaneous dose of T-2 toxin given 1 h before the radioisotope. The system is extremely sensitive, since a significant effect was detected with T-2 toxin doses as low as 0.30 mg/kg, which is about one-te...

journal_title：Toxicology

authors： Faifer GC,Godoy HM

更新日期：1991-01-01 00:00:00

abstract：:This study investigated the effect of astaxanthin (ASX; 3,3-dihydroxybeta, beta-carotene-4,4-dione), a water-dispersible synthetic carotenoid, on liver ischemia-reperfusion (IR) injury. Astaxanthin (5 mg/kg/day) or olive oil was administered to rats via intragastric intubation for 14 consecutive days before the induct...

journal_title：Toxicology

authors： Curek GD,Cort A,Yucel G,Demir N,Ozturk S,Elpek GO,Savas B,Aslan M

更新日期：2010-01-12 00:00:00

abstract：:Inhibition of fungal lanosterol-14 alpha-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine. Inhibition of human CYP51 may result in endocrine disruption since follicular fluid-meiosis activating steroid (FF-MAS), the direct product of lanosterol demethyl...

journal_title：Toxicology

authors： Trösken ER,Adamska M,Arand M,Zarn JA,Patten C,Völkel W,Lutz WK

更新日期：2006-11-10 00:00:00