Changes in the mRNA expression of structural proteins, hormone synthesis and secretion from bovine placentome sections after DDT and DDE treatment.

abstract：:In our experiments on acutely lead exposed rats we observed a marked increase (a 2-fold or 3-fold increase with 30 mg/kg or 60 mg/kg lead acetate, respectively) in [3H]quinuclidinyl benzilate [( 3H]QNB) specific binding to muscarine receptors from striatum and cortex, without any change in receptor affinity. Muscarine...

journal_title：Toxicology

authors： Moingeon P,Bidart JM,Alberici GF,Boudène C,Bohuon C

更新日期：1984-05-14 00:00:00

abstract：:There are reports of alterations in the number and functions of the cells of the immune system in patients with metal-on-metal (MOM) orthopaedic implants. These effects have been correlated with elevated chromium levels in the patients' blood. We have investigated the interactions of clinically relevant concentrations...

journal_title：Toxicology

authors： Lalaouni A,Henderson C,Kupper C,Grant MH

更新日期：2007-07-01 00:00:00

abstract：:The present study was examined whether or not 2-bromoethyamine, a semicarbazide-sensitive amine oxidase (SSAO, EC; 1.4.3.6) inhibitor, would increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical ((*)OH) generation in the rat striatum. Rats were anesthetized, and ...

journal_title：Toxicology

authors： Obata T

更新日期：2006-01-20 00:00:00

abstract：:The present research examines the effects of 4-nonylphenol (4-NP) on mouse primary calvarial osteoblasts (COBs). Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced. In addition, an up-regula...

journal_title：Toxicology

authors： Sabbieti MG,Agas D,Palermo F,Mosconi G,Santoni G,Amantini C,Farfariello V,Marchetti L

更新日期：2011-12-18 00:00:00

abstract：:The aim of this study is to explore the potent neuroprotective effect of calpeptin (CP) on neuron damage induced by acrylamide (ACR) and its mechanism. Behavioural indicators such as hind limb splay, rota-rod performance, and gait analysis were assessed weekly to evaluate neurobehavioural changes after ACR and/or CP a...

journal_title：Toxicology

authors： Su B,Guan Q,Wang M,Liu N,Wei X,Wang S,Yang X,Jiang W,Xu M,Yu S

更新日期：2018-05-01 00:00:00

abstract：:The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...

journal_title：Toxicology

authors： Farina M,Brandão R,de Lara FS,Pagliosa LB,Soares FA,Souza DO,Rocha JB

更新日期：2003-03-03 00:00:00

abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...

journal_title：Toxicology

authors： Noda T,Morita S,Baba A

更新日期：1993-12-31 00:00:00

abstract：:Proliferation and differentiation of cells in female reproductive organs, the oviduct, uterus and vagina, are regulated by endogenous estrogen. In utero exposure to a synthetic estrogen, diethylstilbestrol (DES), induces vaginal clear-cell adenocarcinoma in humans. In mice, perinatal exposure to DES results in abnorma...

journal_title：Toxicology

authors： Nakamura T,Miyagawa S,Katsu Y,Watanabe H,Mizutani T,Sato T,Morohashi K,Takeuchi T,Iguchi T,Ohta Y

更新日期：2012-06-14 00:00:00

abstract：:Ethanol is able to cross the placenta, which may cause teratogenicity. Here we investigated whether ethanol consumption during pregnancy (ECDP), even at doses unable to cause malformation, might increase the susceptibility of fetal rat liver to oxidative insults. Since cholestasis is a common condition in alcoholic li...

journal_title：Toxicology

authors： Perez MJ,Velasco E,Monte MJ,Gonzalez-Buitrago JM,Marin JJ

更新日期：2006-08-15 00:00:00

abstract：:Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Risk of VPA-induced hepatotoxicity is increased in patients with mitochondrial diseases and especially in patients with POLG1 gene mutations. We used a HepG2 cell in vitro model to investigate the effect of VPA on mitochondrial activity. Cells wer...

journal_title：Toxicology

authors： Komulainen T,Lodge T,Hinttala R,Bolszak M,Pietilä M,Koivunen P,Hakkola J,Poulton J,Morten KJ,Uusimaa J

更新日期：2015-05-04 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) is associated with numerous adverse health effects. Although the main route of exposure to PCBs is through the gastrointestinal tract, little is known about the contribution of the gut to the health effects of PCBs. We hypothesize that PCBs can disrupt intestinal integrity,...

journal_title：Toxicology

authors： Choi JJ,Choi YJ,Chen L,Zhang B,Eum SY,Abreu MT,Toborek M

更新日期：2012-12-16 00:00:00

abstract：:The popliteal lymph node assay (PLNA) is being considered as a tool to predict the potential of drugs for inducing systemic autoimmune and hypersensitivity reactions. Despite the use of different technical approaches and the evaluation of over 130 compounds, the sensitivity and specificity of the PLNA are still debata...

journal_title：Toxicology

authors： Ravel G,Christ M,Horand F,Descotes J

更新日期：2004-08-05 00:00:00

abstract：:The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Understanding their interactions within the active site of phosphylated AChE is of great significance for the search for mo...

journal_title：Toxicology

authors： Katalinić M,Šinko G,Maček Hrvat N,Zorbaz T,Bosak A,Kovarik Z

更新日期：2018-08-01 00:00:00

abstract：:Flucloxacillin is a semi-synthetic penicillin widely used in the prophylaxis and treatment of staphylococcal infections. Severe liver reactions, characterised by delayed cholestatic hepatitis and a prolonged course of recovery, are associated with flucloxacillin therapy. Clinical findings are suggestive of an immune m...

journal_title：Toxicology

authors： Carey MA,van Pelt FN

更新日期：2005-12-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are important as drug metabolizing enzymes mainly in the detoxication process. To assess individual differences in susceptibility to different chemicals, it would be useful to know the activity of specific GST isozymes in individuals. In order to study individual variability, typical ...

journal_title：Toxicology

authors： Takamatsu Y,Inaba T

更新日期：1994-03-11 00:00:00

abstract：:Effects of metallothionein (MT) synthesis inhibiting compounds (actinomycin D, cycloheximide), MT synthesis stimulating compounds (dexamethasone, dibu-cAMP) and interfering metals (Cd, Zn) on copper accumulation were investigated in rat hepatoma tissue culture cells. Copper-metallothionein (Cu-MT) and MT-associated co...

journal_title：Toxicology

authors： Steinebach OM,Wolterbeek HT

更新日期：1994-09-06 00:00:00

abstract：:We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...

journal_title：Toxicology

authors： Yamasaki K,Takeyoshi M,Yakabe Y,Sawaki M,Imatanaka N,Takatsuki M

更新日期：2002-01-15 00:00:00

abstract：:We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...

journal_title：Toxicology

authors： Nagai N,Ito Y,Shibata T,Kubo E,Sasaki H

更新日期：2017-04-15 00:00:00

abstract：:Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...

journal_title：Toxicology

authors： Bourian M,Gullstén H,Legrum W

更新日期：2000-04-03 00:00:00

abstract：:Subcutaneous administration of methyl isocyanate (MIC) in 0.5 LD50 and 1 LD50 doses in female rabbits resulted in significant changes in physiological, clinico-chemical and histological parameters. There was a fall in arterial blood pressure and cardioacceleration in both the 0.5 LD50 and 1 LD50 groups, while the resp...

journal_title：Toxicology

authors： Jeevarathinam K,Selvamurthy W,Ray US,Mukhopadhyay S,Thakur L

更新日期：1988-10-01 00:00:00

abstract：:Consumption of edible oils contaminated with Argemone mexicana seed oil is known to cause various clinical manifestations. In the present study, the effect of dietary intake of argemone oil on histopathological changes, haematological indices and selected marker parameters of toxicity was investigated to observe the e...

journal_title：Toxicology

authors： Upreti KK,Das M,Kumar A,Singh GB,Khanna SK

更新日期：1989-10-16 00:00:00

abstract：:The protective effect of telmisartan, the angiotensin II-receptor antagonist, against liver toxicity induced by sodium arsenite (5 mg/kg/day, p.o., for 30 days) was investigated in mice. Telmisartan treatment (10 mg/kg/day, p.o.) was applied for 30 days, starting on the same day of arsenic administration. Telmisartan ...

journal_title：Toxicology

authors： Fouad AA,Al-Mulhim AS,Jresat I

更新日期：2012-10-28 00:00:00

abstract：:Transforming growth factor beta (TGF beta) is a multifunctional regulator of cell growth that has either a stimulatory or inhibitory effect on cell proliferation, depending on TGF beta concentration and on cell type, history and culture conditions. Cadmium mimics some of the effects of TGF beta in cultured cells. In t...

journal_title：Toxicology

authors： Tang N,Enger MD

更新日期：1992-01-01 00:00:00

abstract：:Whole body autoradiograms of mice injected with 2,2',3,3',6-[14C]pentachlorobiphenyl (I), 2,3,3',4',6-[14C]pentachlorobiphenyl (II), 2,2',3,5',6-[14C]pentachlorobiphenyl (III) and 2,3',4,5,5'-[14C]pentachlorobiphenyl (IV) showed a specific accumulation of I-III in the lung parenchyma, whereas IV did not accumulate in ...

journal_title：Toxicology

authors： Brandt I,Mohammed A,Slanina P

更新日期：1981-01-01 00:00:00

abstract：:Aromatase enzyme plays a central role in steroidogenesis by converting androgens to estrogens and has been proposed as an important molecular target for many environmental endocrine disrupters chemicals. In this study, we have screened 30 selected pesticides with known, unknown or supposed effects on aromatase activit...

journal_title：Toxicology

authors： Laville N,Balaguer P,Brion F,Hinfray N,Casellas C,Porcher JM,Aït-Aïssa S

更新日期：2006-11-10 00:00:00

abstract：:It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and nitromethane. Aldo-keto reductases (AKRs) are enz...

journal_title：Toxicology

authors： Su JG,Liao PJ,Huang MC,Chu WC,Lin SC,Chang YJ

更新日期：2008-02-28 00:00:00

abstract：:Mitochondrial fission, fusion, and mitophagy are interlinked processes that regulate mitochondrial shape, number, and size, as well as metabolic activity and stress response. The fundamental importance of these processes is evident in the fact that mutations in fission (DRP1), fusion (MFN2, OPA1), and mitophagy (PINK1...

journal_title：Toxicology

authors： Luz AL,Godebo TR,Smith LL,Leuthner TC,Maurer LL,Meyer JN

更新日期：2017-07-15 00:00:00

abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...

journal_title：Toxicology

authors： Reinhart PG,Bassett DJ,Bhalla DK

更新日期：1998-05-15 00:00:00

abstract：:Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...

journal_title：Toxicology

authors： Chitra KC,Latchoumycandane C,Mathur PP

更新日期：2003-03-14 00:00:00

abstract：:Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation ...

journal_title：Toxicology

authors： Peña D,Pontillo C,García MA,Cocca C,Alvarez L,Chiappini F,Bourguignon N,Frahm I,Bergoc R,Kleiman de Pisarev D,Randi A

更新日期：2012-03-11 00:00:00