Enantiomer-specific, bifenthrin-induced apoptosis mediated by MAPK signalling pathway in Hep G2 cells.

abstract：:Cytochrome P450 (CYP) 2A13 is mainly expressed in the respiratory system and has the ability to metabolize aflatoxin B(1) (AFB(1)). However, the role of CYP2A13-mediated AFB(1) metabolism and its consequences in human lung epithelial cell is not clear. Therefore, the objectives of this study were to investigate the si...

journal_title：Toxicology

authors： Yang XJ,Lu HY,Li ZY,Bian Q,Qiu LL,Li Z,Liu Q,Li J,Wang X,Wang SL

更新日期：2012-10-28 00:00:00

abstract：:Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. ...

journal_title：Toxicology

authors： Fuentes S,Vicens P,Colomina MT,Domingo JL

更新日期：2007-12-05 00:00:00

abstract：:It is accepted practice in presenting organ weight data to express the results relative to the animal's body weight. The data presented suggest that in rats no benefits are obtained from this method either in reducing the variability of the data or in removing bias due to different body weights. By using simulated dat...

journal_title：Toxicology

authors： Stevens MT

更新日期：1976-03-01 00:00:00

abstract：:A mixture of 55% tallow alkyl ethoxylate sulfate (TAE3S) and 45% of linear alkylbenzene sulfonate (LAS) was fed to two generations of rats at dietary levels of 0.1, 0.5 or 1.0%. The rats were fed the surfactant mixture either continuously or during the organogenesis (days 6-15) period of six pregnancies. In addition,...

journal_title：Toxicology

authors： Nolen GA,Klusman LW,Patrick LF,Geil RG

更新日期：1975-05-01 00:00:00

abstract：:Dioxins, including the most toxic congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), exert diverse biological effects in humans and animals. Host resistance, especially to virus infections, is considered one of the most sensitive targets of TCDD-toxicity, while a recent study showed that the vulnerability to TCDD o...

journal_title：Toxicology

authors： Nohara K,Izumi H,Tamura Si,Nagata R,Tohyama C

更新日期：2002-01-15 00:00:00

abstract：:The present work includes a study on the glycosaminoglycanuric condition induced by adriamycin (ADR, a chemotherapeutic agent) and the accompanying secondary hyperlipidemia, wherein the treatment with a low-molecular-weight heparin-derivative (LMWH), certoparin, is evaluated for its protective role (if any) on these p...

journal_title：Toxicology

authors： Deepa PR,Varalakshmi P

更新日期：2005-07-01 00:00:00

abstract：:Organotellurides are important intermediates in organic synthesis and, consequently, the occupational exposure to them is a constant risk for laboratory workers. These compounds can elicit many neurotoxic events in the central nervous system (CNS) that are associated with several neurological symptoms. In contrast, or...

journal_title：Toxicology

authors： Funchal C,Moretto MB,Vivian L,Zeni G,Rocha JB,Pessoa-Pureur R

更新日期：2006-05-01 00:00:00

abstract：:Age-related differences in susceptibility to cephaloridine nephrotoxicity were evaluated in male Fischer-344 rats. Rats, 2.5, 4, 10-12 and 27-29 months old, were administered a single intraperitoneal dose of cephaloridine and renal function evaluated 24 h later. Susceptibility to cephaloridine-induced nephrotoxicity w...

journal_title：Toxicology

authors： Goldstein RS,Pasino DA,Hook JB

更新日期：1986-01-01 00:00:00

abstract：:A single intraperitoneal injection of 10(-6.5) mol lanthanum chloride/g body wt (44 mg metal/kg body wt) into pregnant mice reduced the number of successful pregnancies and the average litter size. The most susceptible periods of pregnancy were peri-implantation (days 4 and 6) and near-term period (days 14 and 16). In...

journal_title：Toxicology

authors： Abramczuk JW

更新日期：1985-03-29 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:Paracetamol, in toxic doses, is associated with extensive liver damage. This represents one of the common causes of morbidity and mortality in drug poisoning cases. This study was undertaken to investigate the possible potentiation of the hepatoprotective action of N-acetylcysteine (NAC) by cimetidine (CMD), an inhibi...

journal_title：Toxicology

authors： Al-Mustafa ZH,Al-Ali AK,Qaw FS,Abdul-Cader Z

更新日期：1997-09-05 00:00:00

abstract：:We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...

journal_title：Toxicology

authors： Henning W,Stürzbecher HW

更新日期：2003-11-15 00:00:00

abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...

journal_title：Toxicology

authors： Nogueira CW,Borges VC,Zeni G,Rocha JB

更新日期：2003-09-30 00:00:00

abstract：:Heavy metals, such as iron and manganese, are involved in neurologic disease. Most often these diseases are associated with abnormal environmental exposures or abnormal accumulations of heavy metals in the body. There is increasing recognition that heavy metals normally present in the body also may play a role in dise...

journal_title：Toxicology

authors： Montgomery EB Jr

更新日期：1995-03-31 00:00:00

abstract：:Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

journal_title：Toxicology

authors： Miller CS

更新日期：1996-07-17 00:00:00

abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...

journal_title：Toxicology

authors： Golub MS,Han B,Keen CL,Gershwin ME

更新日期：1993-07-11 00:00:00

abstract：:As vaccines are undoubtedly classified as pharmaceuticals, they have to be submitted to strict non-clinical safety evaluation. The context of their prophylactic use requires that every effort is made to ensure their safe use. Their safety evaluation is complex as they act through a multistage mechanism in which the va...

journal_title：Toxicology

authors： Verdier F

更新日期：2002-05-15 00:00:00

abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...

journal_title：Toxicology

authors： Hussain S,Boland S,Baeza-Squiban A,Hamel R,Thomassen LC,Martens JA,Billon-Galland MA,Fleury-Feith J,Moisan F,Pairon JC,Marano F

更新日期：2009-06-16 00:00:00

abstract：:The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...

journal_title：Toxicology

authors： Farina M,Brandão R,de Lara FS,Pagliosa LB,Soares FA,Souza DO,Rocha JB

更新日期：2003-03-03 00:00:00

abstract：:The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices o...

journal_title：Toxicology

authors： Gurer-Orhan H,Sabir HU,Ozgüneş H

更新日期：2004-02-15 00:00:00

abstract：:The objective of this study was to establish a hypospadiac rat model by maternal exposure to di-n-butyl phthalate (DBP) and to evaluate the developmental abnormalities of hypospadiac male rats. Timed-pregnant rats were given DBP by gastric intubation at doses of 0, 250, 500, 750 or 1000 mg/kg body weight (bw)/day from...

journal_title：Toxicology

authors： Jiang J,Ma L,Yuan L,Wang X,Zhang W

更新日期：2007-04-11 00:00:00

abstract：:Organophosphates and pyrethroids are among the most common pesticides currently in use worldwide. Several pesticides have been reported to possess hormonal activities, and thus are classified as endocrine disruptors. The present study was planned to evaluate potential androgenic and antiandrogenic activities of the pe...

journal_title：Toxicology

authors： Xu LC,Liu L,Ren XM,Zhang MR,Cong N,Xu AQ,Shao JH

更新日期：2008-01-14 00:00:00

abstract：:Several reports have described the effects of trichloroethylene (TCE) on the microsomal mixed function oxidase system (MFOS). These studies suggest that repeated TCE administration induces MFOS, especially cytochrome P-450 and NADPH-cytochrome c reductase. However, it is uncertain what isozymes are induced by TCE trea...

journal_title：Toxicology

authors： Kawamoto T,Hobara T,Nakamura K,Imamura A,Ogino K,Kobayashi H,Iwamoto S,Sakai T

更新日期：1988-12-30 00:00:00

abstract：:It is widely believed that the nigrostriatal toxicity of MPTP is due to its oxidation by brain monoamine oxidase first to MPDP+, and eventually to MPP+. Following uptake by the synaptic dopamine reuptake system, it is concentrated in the matrix of striatal mitochondria by an energy-dependent carrier, energized by the ...

journal_title：Toxicology

authors： Singer TP,Ramsay RR,McKeown K,Trevor A,Castagnoli NE Jr

更新日期：1988-04-01 00:00:00

abstract：:Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP). PP include chemicals that activate different subtypes of the peroxisome proliferator-activated receptor (PPAR) family. The ability of phthalate esters and their metabolites to activate responses through different PPAR subtype...

journal_title：Toxicology

authors： Lapinskas PJ,Brown S,Leesnitzer LM,Blanchard S,Swanson C,Cattley RC,Corton JC

更新日期：2005-02-01 00:00:00

abstract：:Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...

journal_title：Toxicology

authors： Hochadel JF,Waalkes MP

更新日期：1997-01-15 00:00:00

abstract：:Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produc...

journal_title：Toxicology

authors： Chiu WA

更新日期：2011-07-29 00:00:00

abstract：:Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of...

journal_title：Toxicology

authors： Forkert PG,Sylvestre PL,Poland JS

更新日期：1985-05-01 00:00:00

abstract：:Fischer 344 rats were exposed to filtered air (controls) or to 0.12, 0.5, or 1.0 ppm of ozone for 6 h/day, 5 days/week, for 20 months. We examined lung collagen deposition and metabolism in tissue from these animals to determine whether chronic exposure of rats to ozone causes pulmonary fibrosis. We observed excess st...

journal_title：Toxicology

authors： Last JA,Gelzleichter T,Harkema J,Parks WC,Mellick P

更新日期：1993-11-12 00:00:00

abstract：:For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...

journal_title：Toxicology

authors： Tolonen A,Pelkonen O

更新日期：2015-06-05 00:00:00