Abstract：
:A single intraperitoneal injection of 10(-6.5) mol lanthanum chloride/g body wt (44 mg metal/kg body wt) into pregnant mice reduced the number of successful pregnancies and the average litter size. The most susceptible periods of pregnancy were peri-implantation (days 4 and 6) and near-term period (days 14 and 16). Injection of lanthanum during the peri-implantation period resulted in a cessation of pregnancy in 24-43% of females, and injection during near-term period produced the cessation of pregnancy in 36-46% of the females. The average litter size after injection of lanthanum during peri-implantation or near-term periods was reduced to about 75% of the average litter size in the control animals. No external malformations were observed among fetuses. Paradoxically, the exposure of 1-cell stage embryos to 10(-3.0) M and 10(-3.5) M lanthanum chloride in vitro resulted in a significant improvement of the proportion of embryos developing into blastocysts.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Abramczuk JWdoi
10.1016/0300-483x(85)90142-8subject
Has Abstractpub_date
1985-03-29 00:00:00pages
315-20issue
4eissn
0300-483Xissn
1879-3185pii
0300-483X(85)90142-8journal_volume
34pub_type
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