Abstract:
:Carbon monoxide (CO) gas is a product of the incomplete combustion of carbon-based fuels and substances. From a public health perspective, CO poisoning may be the cause of more than 50% of fatal poisonings in many industrial countries. The adverse effects of CO poisoning may be more widespread because of unreported situations and delayed neurologic effects, which may be linked to CO exposure. Chronic CO effects that are subtle, such as the adverse effects on vascular diseases, may increase the number of people at risk. The apparent role of CO as an important mediator of cell signaling is a paradox and may represent an example of hormesis, i.e. beneficial effects at low concentration but adverse effects at higher concentrations. Nevertheless, because CO can form ligands with iron (heme) and copper sites, the potential for metabolic intervention is likely. Furthermore, CO-induced oxidative stress opens the opportunity for modulating the adverse effects of CO with antioxidants (both water- and lipid-soluble compounds) and various factors involved with reducing oxidative stress. However, consideration must be given to the micro-environment in some situations that could potentially create more oxidation and subsequent metabolic damage if the combinations and concentrations of antioxidants are not correct, i.e. pro oxidant effects. Likewise, it is important that we take precautions in the development of antioxidant adjuvants to use with oxygen therapies in CO poisoning.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Omaye STdoi
10.1016/s0300-483x(02)00387-6keywords:
subject
Has Abstractpub_date
2002-11-15 00:00:00pages
139-50issue
2eissn
0300-483Xissn
1879-3185pii
S0300483X02003876journal_volume
180pub_type
杂志文章,评审相关文献
TOXICOLOGY文献大全abstract::We have determined that the addition of 3-phenylamino-L-alanine (PAA), a recently reported contaminant in L-tryptophan implicated in the eosinophilia-myalgia syndrome, affects tryptophan binding by utilizing an in vitro measurement of 3H-tryptophan binding to hepatic nuclei or nuclear envelopes. PAA (10(-10) to 10(-4)...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90058-2
更新日期:1994-01-26 00:00:00
abstract::A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alky...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90032-5
更新日期:1984-07-01 00:00:00
abstract::The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90119-3
更新日期:1987-07-01 00:00:00
abstract::Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.12.006
更新日期:2018-02-01 00:00:00
abstract::Gender is a factor that influences susceptibility of individuals to drug-induced liver injury in experimental animals and humans. In this study, we investigated the mechanisms underlying resistance of female mice to acetaminophen (APAP)-induced hepatotoxicity. Overnight-fasted male and female CD-1 mice were administer...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.05.018
更新日期:2011-09-05 00:00:00
abstract::There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.01.014
更新日期:2014-05-07 00:00:00
abstract::Indoor suspended particulate matter (SPM) consists of many different types of particles, the vast majority of which are less than 2.5 microm in diameter. An important question is how these particles, being inhalable, contribute to asthma and respiratory symptoms. One possibility is that these particles have an adjuvan...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00079-1
更新日期:1998-08-21 00:00:00
abstract::The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)p...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90006-e
更新日期:1993-07-28 00:00:00
abstract::Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.10.005
更新日期:2005-02-14 00:00:00
abstract::Because occupational hazards of small-scale industries were severe and the occupational health management lagged behind in Shanghai, we selected some districts as experimental units to explore a model of community management and service for the occupational health in small-scale industries for controlling occupational...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.019
更新日期:2004-05-20 00:00:00
abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.08.001
更新日期:2015-10-02 00:00:00
abstract::In the clinical setting, antidotes are generally administered after the occurrence of a drug overdose. Therefore, the most pertinent evaluation of any new agent should model human exposure. This study tested whether acetaminophen (APAP) hepatotoxicity was reversed when S-adenosyl-L-methionine (SAMe) was administered a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.10.027
更新日期:2008-02-03 00:00:00
abstract::The widespread use of tributyltin (TBT) as biocides in antifouling paints and agricultural chemicals has led to environmental and marine pollution. Human exposure occurs mainly through TBT contaminated seafood and drinking water. It is a well known endocrine disruptor in mammals, but its molecular mechanism in testicu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.09.003
更新日期:2013-12-06 00:00:00
abstract::Studies on the pulmonary retention of benzo[a]pyrene after inhalation have shown that clearance is biphasic, with one component clearing with a half-time greater than 1 day and another with a half-time less than 1 day. In the work reported here we demonstrated that the amount of benzo[a]pyrene instilled in the lungs c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90066-6
更新日期:1985-06-28 00:00:00
abstract::We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.12.019
更新日期:2008-03-12 00:00:00
abstract::Exposure to polychlorinated biphenyls (PCBs) is associated with numerous adverse health effects. Although the main route of exposure to PCBs is through the gastrointestinal tract, little is known about the contribution of the gut to the health effects of PCBs. We hypothesize that PCBs can disrupt intestinal integrity,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.08.001
更新日期:2012-12-16 00:00:00
abstract::Exposure of pregnant C3H/HeNCR mice to 42.5- or 85-ppm of arsenic as sodium arsenite in drinking water between days 8 and 18 of gestation markedly increases tumor incidence in their offspring. In the work reported here, distribution of inorganic arsenic and its metabolites, methyl arsenic and dimethyl arsenic, were de...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.041
更新日期:2006-07-05 00:00:00
abstract::Some workers have suggested that 6 days xylitol administration to rats results in hepatic dysfunction. In our study xylitol was administered to rats by daily gastric intubation for a period of 14 days. Dose levels were 1.25, 2.5, 5 and 10 g/kg. During treatment (2, 5 and 14 days), animals were submitted to careful cli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90025-7
更新日期:1977-08-01 00:00:00
abstract::Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.09.004
更新日期:2018-12-01 00:00:00
abstract::The chlorinated acetic acids, in particular dichloroacetic acid (DCA), are found as chlorine disinfection by-products in finished drinking water supplies. DCA has previously been demonstrated to be a mouse liver carcinogen. Chronic studies are described in which male Fischer (F344) rats were exposed to DCA in their dr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03510-x
更新日期:1996-12-18 00:00:00
abstract::The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(79)80003-7
更新日期:1979-05-01 00:00:00
abstract::Sixteen polycyclic aromatic hydrocarbons (PAHs) were screened for their ability to be directly cytotoxic to a cell line from the rainbow trout gill, RTgill-W1. Exposure times of 2 h or less were sufficient for direct cytotoxicity to be detected, which appeared to be caused by a common mechanism, the general perturbati...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00030-4
更新日期:1998-05-15 00:00:00
abstract::Adriamycin (ADR), an anthracycline antibiotic, which is widely used as an antineoplastic drug in the treatment of various solid tumors, has been shown to induce genotoxicity in erythropoietic system. The aim of the present study was to investigate the protective efficacy of DL-alpha-lipoic acid (LA) on ADR-induced cla...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.015
更新日期:2006-05-15 00:00:00
abstract::We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.007
更新日期:2006-05-01 00:00:00
abstract::The aim of this study was to compare the roles of dihydropyridine calcium antagonists nifedipine, nitrendipine, amlodipine on doxorubicin (DXR)-induced nephrotoxicity in rats using biochemical, histopathological and immunohistochemical approaches. Male Sprague-Dawley rats were randomly divided into five experimental g...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.11.067
更新日期:2007-02-28 00:00:00
abstract::The toxic oil syndrome (TOS), a multisystemic disease, that occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline. Due to the clinical course of the disease, immunopathological mechanisms have been suspected but a direct connection was never demonstrated. To analyse this poss...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90085-x
更新日期:1994-11-11 00:00:00
abstract::Benzene, an important industrial solvent, is also present in unleaded gasoline and cigarette smoke. The hematotoxic effects of benzene in humans are well documented and include aplastic anemia and pancytopenia, and acute myelogenous leukemia. A combination of metabolites (hydroquinone and phenol for example) is appare...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03217-4
更新日期:1995-12-28 00:00:00
abstract::A clonal cell line, R40F, was selected from a heterogenous population of Cd2+ and Zn2+-resistant CHO-K1 cells. These R40F cells demonstrated resistance to 120- and 4-fold higher concentrations of Cd2+ and Zn2+, respectively, than did wild type CHO-K1 cells. When cultured in the presence of low concentrations of Cd2+ (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90088-4
更新日期:1983-03-01 00:00:00
abstract::The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(96)03494-4
更新日期:1996-12-31 00:00:00
abstract::Maize co-contamination with aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is frequently found in several countries. Although the alterations on nutritional and immunologic parameters induced by these mycotoxins, when administered individually, are partially characterised, little is known about the effects induced in anim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00603-0
更新日期:2003-04-15 00:00:00