Abstract:
:Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical drug therapy. The pathogenesis of DILI usually involves the participation of the parent drug or metabolites that either directly affect the cell biochemistry or elicit an immune response. However, in most cases the mechanisms are unknown. Alpha-naphthylisothiocyanate (ANIT) is known as a hepatotoxicant that causes biliary cell and hepatocyte damage and induces intense neutrophil infiltration in the liver. To investigate whether an immune-mediated mechanism is involved in ANIT-induced liver injury, we examined the plasma AST, ALT and T-Bil levels, hepatic expression of transcriptional factors, cytokines and CXC chemokine genes, plasma IL-17 level and histopathological changes in liver after ANIT administration in mice. Hepatic mRNA expression of retinoid related orphan receptor gamma t (ROR gamma t) and macrophage inflammatory protein (MIP-2) and plasma IL-17 level was significantly increased in ANIT-administered mice as well as the plasma AST, ALT and T-Bil. Neutralization of IL-17 using anti-IL-17 antibody (100 microg/mouse, single i.p.) suppressed the hepatotoxic effect of ANIT. Co-administration of recombinant IL-17 (1 microg/mouse, single i.p.) to ANIT-administered mice resulted in a remarkable increase of the plasma AST, ALT and T-Bil levels. In conclusion, it was firstly demonstrated that IL-17 is involved in the ANIT-induced liver injury in mice.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kobayashi M,Higuchi S,Mizuno K,Tsuneyama K,Fukami T,Nakajima M,Yokoi Tdoi
10.1016/j.tox.2010.05.011subject
Has Abstractpub_date
2010-09-10 00:00:00pages
50-7issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(10)00243-Xjournal_volume
275pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The mean concentrations of polybrominated diphenyl ethers (PBDEs) (sum tetra- to octaBDEs) were determined in samples of foodstuffs widely consumed by the population of Catalonia, Northeast Spain. The following six tetra-through heptabrominated congeners were also individually analyzed: PBDEs 47, 99, 100, 153, 154 and...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2008.03.006
更新日期:2008-06-03 00:00:00
abstract::Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, howev...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2021.152679
更新日期:2021-01-15 00:00:00
abstract::Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisatio...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90192-h
更新日期:1992-12-04 00:00:00
abstract::The mechanism of delta-aminolevulinate dehydratase (delta-ALA-D) inhibition by phenyl selenoacetylene in vitro was investigated in this study. Phenyl selenoacetylene (40-400 microM) inhibition of delta-aminolevulinate dehydratase from rat liver (low speed supernatant fraction, S1 fraction) was partially prevented by i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.08.001
更新日期:2005-01-31 00:00:00
abstract::Rats poisoned with one LD50 of thiopental or amytal are shown to increase oxygen consumption when intraperitoneally given sucinate, malate, citrate, alpha-ketoglutarate, dimethylsuccinate or glutamate (the Krebs cycle intermediates or their precursors) but not when given glucose, pyruvate, acetate, benzoate or nicotin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.05.005
更新日期:2004-10-01 00:00:00
abstract::Human liver microsomes, supersomes from baculovirus-transformed insect cells expressing different human CYP450 isoforms, and control and CYP3A4 cDNA-transfected V79 Chinese hamster cells were tested for their ability to metabolize territrem B (TRB) and territrem C (TRC). Two TRB metabolites, designated MB(2) and MB(4)...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.10.010
更新日期:2006-02-01 00:00:00
abstract::Fenvalerate is a widely used synthetic pyrethroid insecticide and is reported to disrupt reproductive function in humans and animals. However, little is known about its influence on follicular development. In this study, rat preantral follicles were primary cultured to investigate the effects of fenvalerate on follicu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.10.022
更新日期:2010-01-12 00:00:00
abstract::The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-am...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90103-1
更新日期:1980-01-01 00:00:00
abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00108-5
更新日期:1998-11-02 00:00:00
abstract::Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.06.010
更新日期:2014-09-02 00:00:00
abstract::Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.011
更新日期:2019-05-15 00:00:00
abstract::Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00403-6
更新日期:2001-08-13 00:00:00
abstract::Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. Since it is possible that extragonadal changes contribute to the appearance of such effects, the present study focused on the presence of concurrent endocrine changes in th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90163-7
更新日期:1989-07-17 00:00:00
abstract::Feeding of rats with 1% ethoxyquin (EQ) and butylated hydroxytoluene (BHT) but not butylated hydroxyanisole (BHA) increases the formation rate of benzo[a]pyrene (BP)-4,5-dihydrodiol from BP in hepatic microsomes. The production of other BP-dihydrodiols and of BP phenols is decreased after treatment with EQ, BHT and BH...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90120-8
更新日期:1983-01-01 00:00:00
abstract::Quartz is a well-known occupational fibrogenic agent able to cause fibrosis and other severe pulmonary diseases such as silicosis and lung cancer. The silicotic pathology owes its severity to the structural and chemo-physical properties of the particles such as shape, size and abundance of surface radicals. In earlier...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.07.001
更新日期:2016-06-15 00:00:00
abstract::The development of poisons information centers has in general complied with the actual needs and conditions in the society, and a pragmatic approach and limited funds have been characteristic for these units. To operate in a satisfying way a poisons information center is dependent on two cornerstones-a well educated a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.033
更新日期:2004-05-20 00:00:00
abstract::The long-term clinical usefulness of doxorubicin (DOX), an anthracycline with potent antitumor activity, is limited by DOX-induced cardiotoxicity. Kaempferol, one of the most common dietary flavonoids, is known to have anti-apoptotic, anti-oxidative, and anti-inflammatory properties. The current study aimed to investi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.11.018
更新日期:2012-02-06 00:00:00
abstract::To meet the military objective of determining criteria for incapacitation and lethality from toxic gas exposures, a series of small animal tests and data analyses were conducted. Carbon monoxide (CO), a narcotic gas and nitrogen dioxide (NO2), an irritant gas, along with carbon dioxide (CO2) were tested individually a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03504-4
更新日期:1996-12-31 00:00:00
abstract::Recent studies have demonstrated that mammalian sperm are capable of generating reactive oxygen species (ROS) and that this activity is significantly accelerated in subfertile subjects. The observed decrease in penetration of zona-intact oocyte might be explained by chemical-induced ROS-related early onset of capacita...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00107-9
更新日期:1999-11-29 00:00:00
abstract::Recent epidemiological studies have reported associations between the consumption of chlorinated drinking water and various types of human cancer; in addition, exposure to chlorine (Cl-) in drinking water has been reported to suppress certain immune functions in laboratory animals. The current studies were conducted t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00163-7
更新日期:1998-01-16 00:00:00
abstract::Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects of ACO and other related compounds on ion currents in Jurkat T-lymphocytes were investigated in this study. ACO suppres...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.07.003
更新日期:2011-10-28 00:00:00
abstract::Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00024-4
更新日期:1999-05-03 00:00:00
abstract::The present research examines the effects of 4-nonylphenol (4-NP) on mouse primary calvarial osteoblasts (COBs). Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced. In addition, an up-regula...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.10.014
更新日期:2011-12-18 00:00:00
abstract::Infusion of hexadecafluoroheptane, a liquid perfluorocarbon released from repaired Althane dialysers was found to be the most probable reason for the deaths of 53 dialysis patients reported in the year 2001. This study focuses on toxic decomposition products generated due to gamma and beta sterilisation of hexadecaflu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.10.008
更新日期:2008-01-20 00:00:00
abstract::The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90042-8
更新日期:1984-12-01 00:00:00
abstract::The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00267-1
更新日期:2003-12-01 00:00:00
abstract::Thiols are known to influence the metabolism of glutathione. In a previous study (Toxicology 156 (2001) 93) dithiothreitol (DTT) did not show any effect on intra- or extracellular glutathione concentrations in HeLa cell cultures but increased the effects of mercury ions on glutathione concentrations, whereas monothiol...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00060-4
更新日期:2002-06-14 00:00:00
abstract::Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.01.001
更新日期:2011-03-15 00:00:00
abstract::The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). We have now investigated the presence of both the 4 S PAH-binding protein and the 8 S Ah receptor in rat hep...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90217-o
更新日期:1991-02-01 00:00:00
abstract::A new methodology for estimating the probabilistic risk from acute toxic exposures is planned as a support tool for the Air Force at the Eastern and Western Ranges. Two such methodologies are programs entitled the Launch Area Toxic Analysis program (LATRA) and the Cold Spill Toxic Risk Analysis program (COSTRA). These...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(96)03380-x
更新日期:1996-07-17 00:00:00