Abstract：
:Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the host disorders and bacterial functions involved in PCB77 exposure remain largely unknown. Few studies have been performed to illuminate the correlation between the bacterial functions and disorders. Furthermore, it is urgently needed to find specific strains as potential biomarkers to monitor PCB77 pollution and associated disorders. This study was designed to investigate the effects of PCB77 on gut microbiota and induced disorders in female mice. Obtained results indicated that PCB77 exposure induced gut microbiota dysbiosis, obesity, hyperlipidemia, hepatic lipid accumulation, and liver injury in mice. Functional prediction based on the phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) algorithm showed that exposure to PCB77 weakened the bacterial functions relating to lipid and energy metabolism, and immune system disease. Experimental findings were consistent with the result of the PICRUSt functional prediction. Importantly, three PCB77-associated bacterial taxa were screened out as potential biomarkers for the assessment of PCB77 pollution. This study provides previously unknown knowledge linking PCB77 administration, gut microbiota functional profile and lipid abnormalities, which is of important clinical significance for therapies treating PCB77-associated diseases.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Chi Y,Wang H,Lin Y,Lu Y,Huang Q,Ye G,Dong Sdoi
10.1016/j.tox.2019.03.011subject
Has Abstractpub_date
2019-05-15 00:00:00pages
11-20eissn
0300-483Xissn
1879-3185pii
S0300-483X(18)30749-2journal_volume
420pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Teratogenicity of daily intraperitoneal (i.p.) injections of 1.5 or 2.0 mg/kg of patulin on days 6 through 17 of pregnancy and mutagenic effects of acute i.p. exposure of 3.0 mg/kg of patulin on male germ cells were evaluated. Resorption of all implanted embryos occurred at 2.0 mg/kg/day of patulin, while a significan...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(78)91339-2
更新日期：1978-11-01 00:00:00
abstract：:This paper introduces the special issue on quantitative in vitro-in vivo extrapolations (QIVIVE). It highlights important issues in the development of in vitro toxicology towards its implementation in toxicological risk assessment. ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.04.004
更新日期：2015-06-05 00:00:00
abstract：:Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00382-7
更新日期：2002-10-30 00:00:00
abstract：:The rodent Hershberger assay has been used predominantly by the pharmaceutical industry to evaluate androgenic and antiandrogenic chemicals for potential therapeutic use. However, this assay has not yet been formally validated and standardized for use in toxicology testing. There are many variations in the protocol us...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00361-4
更新日期：2001-05-11 00:00:00
abstract：:Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00416-9
更新日期：2001-05-28 00:00:00
abstract：:Unfortunately, the principal routine toxicology methods employed for the safety assessment of new products are over 40 years old and rely primarily on histopathological evaluation. It is difficult to introduce newer immunotoxicology or molecular toxicology methods into toxicity assessment without extensive and time co...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03601-3
更新日期：1997-04-11 00:00:00
abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90074-4
更新日期：1994-11-11 00:00:00
abstract：:The widespread use of tributyltin (TBT) as biocides in antifouling paints and agricultural chemicals has led to environmental and marine pollution. Human exposure occurs mainly through TBT contaminated seafood and drinking water. It is a well known endocrine disruptor in mammals, but its molecular mechanism in testicu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.09.003
更新日期：2013-12-06 00:00:00
abstract：:Recent Canadian research efforts have been directed towards the development of a reactive skin decontaminant (RSD) lotion active against classical nerve agents and mustard. The formulation presently under study consists of a 1.25 molal solution of potassium 2,3-butanedione monoximate (KBDO) in polyethylene glycol meth...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90028-y
更新日期：1991-05-01 00:00:00
abstract：:Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00542-5
更新日期：2003-02-01 00:00:00
abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90029-x
更新日期：1978-02-01 00:00:00
abstract：:The breast cancer resistance protein (Bcrp) is an efflux transporter that participates in the biliary and renal excretion of drugs and environmental chemicals. Recent evidence suggests that pharmacological activation of the peroxisome proliferator activated receptor alpha (PPARα) can up-regulate the hepatic expression...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.02.009
更新日期：2013-04-05 00:00:00
abstract：:Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.01.017
更新日期：2015-04-01 00:00:00
abstract：:The in vivo toxicity of the novel copper-based anticancer agent, casiopeina II (Cu(4,7-dimethyl-1,10-phenanthroline)(glycine)NO3) (CII), was investigated. Casiopeinas are a family of copper-coordinated complexes that have shown promising anticancer activity. The major toxic effect attributed to a single i.v. administr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.08.009
更新日期：2003-12-15 00:00:00
abstract：:Lead exposure causes cognitive and behavioral deficits in some children. We have proposed that the effects of single nucleotide polymorphisms (SNP) of the human pseudodeficient arylsulfatase A (ARSA) gene that result in reduced levels of the enzyme, and lead concentrations that decrease ARSA activity, culminate in cel...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00387-0
更新日期：2001-06-21 00:00:00
abstract：:The effects of acute ethanol and acetaldehyde treatment on cell proliferation, cell adhesion capacity, neutral red incorporation into lysosomes, glutathione content, protein sulfhydryl compounds, lipid peroxidation, inner mitochondrial membrane integrity (MTT test), lactate dehydrogenase activity (LDH) and ultrastruct...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)03650-0
更新日期：1997-06-27 00:00:00
abstract：:Glutathione S-transferases (GSTs) are important as drug metabolizing enzymes mainly in the detoxication process. To assess individual differences in susceptibility to different chemicals, it would be useful to know the activity of specific GST isozymes in individuals. In order to study individual variability, typical ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90120-1
更新日期：1994-03-11 00:00:00
abstract：:The present work includes a study on the glycosaminoglycanuric condition induced by adriamycin (ADR, a chemotherapeutic agent) and the accompanying secondary hyperlipidemia, wherein the treatment with a low-molecular-weight heparin-derivative (LMWH), certoparin, is evaluated for its protective role (if any) on these p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.02.009
更新日期：2005-07-01 00:00:00
abstract：:In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00570-4
更新日期：2002-02-28 00:00:00
abstract：:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.11.008
更新日期：2010-11-28 00:00:00
abstract：:Ketamine, an anaesthetic agent used in newborns and toddlers, has been shown to induce neurodegeneration and alter adult behavior in mice, when administered during the neonatal period. Mammals have a marked period of rapid brain growth and development (BGS), which is postnatal in mice and rats, spanning the first 3-4 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.04.019
更新日期：2008-07-30 00:00:00
abstract：:A major goal in modern pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersens...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2005.07.023
更新日期：2005-12-15 00:00:00
abstract：:Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.11.001
更新日期：2010-01-12 00:00:00
abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.10.002
更新日期：2016-09-14 00:00:00
abstract：:Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Risk of VPA-induced hepatotoxicity is increased in patients with mitochondrial diseases and especially in patients with POLG1 gene mutations. We used a HepG2 cell in vitro model to investigate the effect of VPA on mitochondrial activity. Cells wer...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.03.001
更新日期：2015-05-04 00:00:00
abstract：:Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.11.005
更新日期：2004-03-01 00:00:00
abstract：:We have found that incubation of heparin plasma with Ni(2+) or Co(2+) at concentrations below 100 microM can stimulate the conversion of complement factor C3 to C3b faster than magnesium, which is the natural cofactor in the alternative complement activation. This conversion was monitored by light absorbance measureme...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00590-5
更新日期：2003-03-14 00:00:00
abstract：:An experimental approach was taken to the question of dose-response curves for chemical carcinogenesis, using DNA damage as a biomarker. Female rats were give 13 different doses of 1,2-dimethylhydrazine (from 1.4 to 135,000 micrograms/kg) and the subsequent hepatic DNA damage was determined by the alkaline elution tec...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03478-6
更新日期：1996-12-02 00:00:00
abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.028
更新日期：2006-05-01 00:00:00
abstract：:Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.09.006
更新日期：2015-12-02 00:00:00
