Abstract：
:Teratogenicity of daily intraperitoneal (i.p.) injections of 1.5 or 2.0 mg/kg of patulin on days 6 through 17 of pregnancy and mutagenic effects of acute i.p. exposure of 3.0 mg/kg of patulin on male germ cells were evaluated. Resorption of all implanted embryos occurred at 2.0 mg/kg/day of patulin, while a significant reduction in the average body weight of 19-day-old fetuses from patulin-treated mothers, compared to control fetuses, was noticed at 1.5 mg/kg/day without any lethal effects on the implanted embryos. Patulin was embryocidal, possibly fetotoxic but was neither teratogenic nor mutagenic to mice.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Reddy CS,Chan PK,Hayes AWdoi
10.1016/s0300-483x(78)91339-2subject
Has Abstractpub_date
1978-11-01 00:00:00pages
219-23issue
3eissn
0300-483Xissn
1879-3185journal_volume
11pub_type
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