Abstract：
:Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, however, guidance values for DAPs based on health effects have yet to be established. The present study aimed to clarify the relationship between the amount of urinary dimethylphosphate (DMP), a metabolite of dichlorvos (DDVP), and the inhibition of cholinesterase (ChE) activity in rats exposed to DDVP. The relationship was analyzed using a nonlinear model analysis, and the excretion level of urinary DMP equivalent to ChE 20 % inhibition (EL20) and the lower limit of the 95 % confidence interval of EL20 (ELL20) were estimated. EL20 and ELL20 (mg/24 h urine) of brain, erythrocyte, and plasma ChE activities after 10-day administration of DDVP were 0.21 and 0.15, 0.11 and 0.06, and 0.23 and 0.09, respectively. Extrapolating ELL20 of the brain ChE to humans, the range of 24 h urinary DMP concentration according to the 20 % inhibition of cholinesterase activity was estimated to be 20.5-30.8 mg/l. In conclusion, the amount of urinary DMP as ELL20 for DDVP exposure was identified and could probably be used as a novel index for the assessment of risk from OP exposure. Further studies are needed to clarify the ELL20 s derived from OPs other than DDVP, for informing efforts to establish guidance values of urinary OP metabolites that should prevent neurotoxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Sato H,Ito Y,Hanai C,Nishimura M,Ueyama J,Kamijima Mdoi
10.1016/j.tox.2021.152679subject
Has Abstractpub_date
2021-01-15 00:00:00pages
152679eissn
0300-483Xissn
1879-3185pii
S0300-483X(21)00002-0journal_volume
450pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Administration of the antiarrhythmic drug amiodarone to humans or animals may result in lung damage. Amiodarone is metabolized to desethylamiodarone and other minor metabolites. Because amiodarone and the metabolites accumulate in the lungs, it is not possible to ascertain the role of each of these compounds in the in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90112-t
更新日期：1990-05-31 00:00:00
abstract：:Short term exposure of cultured chick ganglia nerve fibers and neuroglia to selenite produced half maximal inhibitory growth effects in concentrations of 6.2 (2.9--13.0) X 10(-5) M and 1.1 (0.7--1.7) X 10(-4) M, respectively. Complete inhibition of growth for both cell types was apparent at 1 X 10(-3) M, while slight ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90041-0
更新日期：1978-02-01 00:00:00
abstract：:We have determined that the addition of 3-phenylamino-L-alanine (PAA), a recently reported contaminant in L-tryptophan implicated in the eosinophilia-myalgia syndrome, affects tryptophan binding by utilizing an in vitro measurement of 3H-tryptophan binding to hepatic nuclei or nuclear envelopes. PAA (10(-10) to 10(-4)...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90058-2
更新日期：1994-01-26 00:00:00
abstract：:Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2004.11.027
更新日期：2005-03-15 00:00:00
abstract：:The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152684
更新日期：2021-01-25 00:00:00
abstract：:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...
journal_title：Toxicology
pub_type：
doi：10.1016/j.tox.2020.152421
更新日期：2020-04-30 00:00:00
abstract：:Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment. Thiopronin contains an SH-group and is generally considered an antioxidant. The aim of the present study was to investigate the effects of thiopronin during liver injury and DNA damage induced by ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.08.006
更新日期：2009-10-29 00:00:00
abstract：:Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.11.005
更新日期：2014-01-06 00:00:00
abstract：:Osteotoxic compounds administered during pregnancy can initiate skeletal congenital anomalies in the embryo. In vitro, developmental osteotoxicity of a compound can be predicted with the embryonic stem cell test (EST), the only in vitro embryotoxicity model identified to date that entirely abrogates the use of animals...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.08.016
更新日期：2010-11-09 00:00:00
abstract：:The early neonatal stage constitutes a sensitive period during which exposure to adverse events can increase the risk of neuropsychiatric disorders. Maternal deprivation (MD) is a model of early life stress that induces long-term behavioural and physiological alterations, including susceptibility to different drugs of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.12.003
更新日期：2013-09-06 00:00:00
abstract：:The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)03662-7
更新日期：1997-07-11 00:00:00
abstract：:Both simultaneous and sequential exposure to heavy metals and aryl hydrocarbon receptor (AHR)-ligands potentially occur in human populations, yet there have been relatively few studies of combined effects of heavy metals and AHR-ligands on AHR-regulated genes. To investigate the effects of heavy metals on AHR-regulate...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.04.011
更新日期：2004-09-01 00:00:00
abstract：:Exposure of rats to 0.1 and 0.5 mg Cd/kg subcutaneously (s.c.) thrice weekly for 5 weeks resulted in an accumulation of cadmium in the liver in concentrations of 40 and 95 micrograms/g tissue, respectively, and a microsomal burden of Cd amounting to approx. 2-3% of the retained cadmium. The cytoplasm contained about 8...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90079-9
更新日期：1984-09-14 00:00:00
abstract：:The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis were observed, but herein, analysis o...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.10.004
更新日期：2011-12-18 00:00:00
abstract：:In the present work was analyzed whether sulforaphane (SFN) may protect against cisplatin (CIS)-induced hepatic damage, oxidant stress and mitochondrial dysfunction. Four groups of male Wistar rats were studied: control, CIS, CIS+SFN and SFN. SFN was given i.p. (500 μg/kg/d × 3 days) before CIS administration (single ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.04.014
更新日期：2011-08-15 00:00:00
abstract：:Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90103-8
更新日期：1983-09-01 00:00:00
abstract：:The immunohistochemical localization of G alpha q/G alpha 11 was studied in the olfactory neuroepithelium of the channel catfish. Antigenicity in the rosette was found at the apical surfaces of cells, within the apical neck regions of some cells, and within the area of the basal nerve tracts. Specific labeling was eli...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03558-5
更新日期：1997-02-28 00:00:00
abstract：:The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(76)90048-2
更新日期：1976-03-01 00:00:00
abstract：:Glutathione (GSH) plays an important role in the metabolism of arsenite and arsenate by generating arsenic-glutathione complexes. Although dimethylarsinic acid (DMA(V)) is the major metabolite of inorganic arsenicals (iAs) in urine, it is not clear how DMA(V) is produced from iAs. In the present study we report that S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.07.009
更新日期：2006-10-03 00:00:00
abstract：:LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00017-7
更新日期：1999-06-15 00:00:00
abstract：:The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00292-4
更新日期：2000-11-02 00:00:00
abstract：:Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00083-9
更新日期：1999-10-29 00:00:00
abstract：:Acute toxic effects of the antineoplastic anthraquinones carminomycin, epirubicin, idarubicin and mitoxantrone were studied in primary cultures of cardiomyocytes, which were isolated from adult rats. Both time- and concentration-dependent changes of cell structure and viability (trypan blue exclusion) following incuba...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00041-4
更新日期：1999-07-01 00:00:00
abstract：:Zearalenone (ZEN) is a non-steroidal oestrogenic mycotoxin produced by several Fusarium species growing on cereals. ZEN and its metabolites bind to human oestrogen receptors and hence display oestrogenic and anabolic properties. Several lines of investigation suggest that ZEN may be genotoxic in vivo. ZEN damages DNA ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00329-9
更新日期：2003-11-05 00:00:00
abstract：:The use of zinc as a nutritional supplement has become common in many countries. Since zinc has diverse actions, it may be difficult to predict its synergistic and/or antagonistic action in simultaneous presence of drug(s). The combination of imidazole antifungals, but not triazole antifungals, with 3-30 microM ZnCl2 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.03.022
更新日期：2008-06-27 00:00:00
abstract：:Osteoporosis is associated with many etiological causes such as nutrition, cytokines, hormones, and aging. Recently, reactive oxygen species (ROS) are considered to be responsible for the aging process and osteoporosis. We investigated the relationship between ROS and bone metabolism in young female and postmenopausal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.12.006
更新日期：2004-04-15 00:00:00
abstract：:Cytochrome P450 (CYP) 2A13 is mainly expressed in the respiratory system and has the ability to metabolize aflatoxin B(1) (AFB(1)). However, the role of CYP2A13-mediated AFB(1) metabolism and its consequences in human lung epithelial cell is not clear. Therefore, the objectives of this study were to investigate the si...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.06.010
更新日期：2012-10-28 00:00:00
abstract：:The development of poisons information centers has in general complied with the actual needs and conditions in the society, and a pragmatic approach and limited funds have been characteristic for these units. To operate in a satisfying way a poisons information center is dependent on two cornerstones-a well educated a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.01.033
更新日期：2004-05-20 00:00:00
abstract：:Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and during lactation until 21 days post partum. An effect on live litter size was noted at the higher doses as was an increased tendency for sperm positive females to fail to produce a litt...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90122-0
更新日期：1981-01-01 00:00:00
abstract：:High-throughput in vitro toxicity screening provides an efficient way to identify potential biological targets for environmental and industrial chemicals while conserving limited testing resources. However, reliance on the nominal chemical concentrations in these in vitro assays as an indicator of bioactivity may misr...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.05.012
更新日期：2015-06-05 00:00:00
