Abstract:
:LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly, LoVoDx cells which had become about 10-fold less sensitive to doxorubicin by incubation in increasing concentrations of this cytostatic drug were also less sensitive to the toxicity of okadaic acid. Resistance to both agents was lost or significantly reduced by incubation in drug-free medium for about 4 months. On the other hand, LoVoDx cells did not lose responsiveness to the structurally different phosphatase inhibitor cantharidic acid but were about twofold more sensitive to the cytotoxic effect of this agent. Thus, MDR expression protects LoVo cells from the toxicity of phosphatase inhibitors that presumably are substrates of the P-glycoprotein, e.g. okadaic acid and its derivatives but not cantharidic acid, despite the fact that both agents are potent inducers of apoptotic cell death via ser/thr phosphatase inhibition.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Sieder S,Richter E,Becker K,Heins R,Steinfelder HJdoi
10.1016/s0300-483x(99)00017-7keywords:
subject
Has Abstractpub_date
1999-06-15 00:00:00pages
109-15issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(99)00017-7journal_volume
134pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00150-1
更新日期:2003-07-15 00:00:00
abstract::The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90129-0
更新日期:1986-05-01 00:00:00
abstract::We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.12.019
更新日期:2008-03-12 00:00:00
abstract::The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)03662-7
更新日期:1997-07-11 00:00:00
abstract:OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.09.014
更新日期:2006-01-20 00:00:00
abstract::The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompani...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90215-1
更新日期:1989-05-31 00:00:00
abstract::Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90173-8
更新日期:1985-03-15 00:00:00
abstract::In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90039-u
更新日期:1993-12-31 00:00:00
abstract::Deoxynivalenol (DON) is one of the major mycotoxic contaminants of grains, which causes reduced weight gain in pigs. The cytotoxicity of DON to porcine hepatocytes was examined in this study. DON was added at the final concentration of 100, 10, 1, 0.1 or 0.01 microg/ml to the medium of primary cultured hepatocytes. Ce...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.07.001
更新日期:2004-11-15 00:00:00
abstract::Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.02.014
更新日期:2013-04-05 00:00:00
abstract::Recently it has become clear that exposure to xenobiotics may result in various forms of cell death; not only passive cell deaths like necrosis, or programmed cell deaths such as apoptosis, but also regulated necrosis, autophagy, senescence, or mitotic catastrophe. Complex cell signaling networks influence the process...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2012.12.014
更新日期:2013-02-08 00:00:00
abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00108-5
更新日期:1998-11-02 00:00:00
abstract::We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00291-9
更新日期:2003-11-15 00:00:00
abstract::Pilinskaya showed that the fungicide ziram induced chrocosome aberrations in the lymphocytes of exposed industrial workers and also in lymphocyte cultures treated in vitro. Ziram is chemically similar to the drug Antabuse (disulfirm) which is used in the treatment of alcoholics. To establish whether disulfirm can also...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90055-4
更新日期:1975-07-01 00:00:00
abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) has proven to be an effective experimental agricultural fungicide. However, NDPS produces marked nephrotoxicity in Sprague-Dawley and Fischer 344 rats. The purpose of this study was to determine the importance of an intact, unsubstituted succinimide ring for acute NDPS-induced ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90113-1
更新日期:1985-10-01 00:00:00
abstract::Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.12.009
更新日期:2007-03-07 00:00:00
abstract::We determined the threshold concentration of sarin vapor exposure producing miosis in African green monkeys (Chlorocebus aethiops). Monkeys (n=8) were exposed to a single concentration of sarin (0.069-0.701mg/m3) for 10min. Changes in pupil size were measured from photographs taken before and after the exposure. Sarin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.11.004
更新日期:2008-02-28 00:00:00
abstract::Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(96)03393-8
更新日期:1996-07-17 00:00:00
abstract::It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02900-f
更新日期:1995-01-06 00:00:00
abstract::We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA(10) or 20 mg/kg per day-CyA(20) for 4 weeks) in rats. CyA treatment reduced the liver content of total gluta...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.02.030
更新日期:2004-07-15 00:00:00
abstract::Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.03.018
更新日期:2011-07-11 00:00:00
abstract::Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chemical phototoxicity using mouse 3T3 fibroblasts. However, the high rat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.01.003
更新日期:2017-03-01 00:00:00
abstract::D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules. The onset is rapid, occurring within 3-4 h and accompanied by proteinuria, glucosuria and aminoaciduria. The metabolism of D-serine by D-amino acid oxidase (D-AAO) may be involved in the mechanism of toxicity. D-AAO is locali...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.08.008
更新日期:2005-02-01 00:00:00
abstract::Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an int...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.05.002
更新日期:2006-07-25 00:00:00
abstract::The cardiovascular effects of trazodone, a broad-spectrum antidepressant and its analogue etoperidone, were compared with imipramine, following intravenous infusion in rats. Their effects on electrocardiogram and blood pressure were simultaneously recorded until cardiac arrest. Hypotension was the primary effect of tr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(78)90065-3
更新日期:1978-06-01 00:00:00
abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.08.001
更新日期:2015-10-02 00:00:00
abstract::In our experiments on acutely lead exposed rats we observed a marked increase (a 2-fold or 3-fold increase with 30 mg/kg or 60 mg/kg lead acetate, respectively) in [3H]quinuclidinyl benzilate [( 3H]QNB) specific binding to muscarine receptors from striatum and cortex, without any change in receptor affinity. Muscarine...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90005-2
更新日期:1984-05-14 00:00:00
abstract:BACKGROUND:Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.01.012
更新日期:2019-03-15 00:00:00
abstract::The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.05.012
更新日期:2010-09-10 00:00:00
abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90085-f
更新日期:1991-01-01 00:00:00