Doxorubicin-resistant LoVo adenocarcinoma cells display resistance to apoptosis induction by some but not all inhibitors of ser/thr phosphatases 1 and 2A.

Abstract:

:LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly, LoVoDx cells which had become about 10-fold less sensitive to doxorubicin by incubation in increasing concentrations of this cytostatic drug were also less sensitive to the toxicity of okadaic acid. Resistance to both agents was lost or significantly reduced by incubation in drug-free medium for about 4 months. On the other hand, LoVoDx cells did not lose responsiveness to the structurally different phosphatase inhibitor cantharidic acid but were about twofold more sensitive to the cytotoxic effect of this agent. Thus, MDR expression protects LoVo cells from the toxicity of phosphatase inhibitors that presumably are substrates of the P-glycoprotein, e.g. okadaic acid and its derivatives but not cantharidic acid, despite the fact that both agents are potent inducers of apoptotic cell death via ser/thr phosphatase inhibition.

journal_name

Toxicology

journal_title

Toxicology

authors

Sieder S,Richter E,Becker K,Heins R,Steinfelder HJ

doi

10.1016/s0300-483x(99)00017-7

keywords:

subject

Has Abstract

pub_date

1999-06-15 00:00:00

pages

109-15

issue

2-3

eissn

0300-483X

issn

1879-3185

pii

S0300-483X(99)00017-7

journal_volume

134

pub_type

杂志文章
  • UV-induced skin damage.

    abstract::Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-483x(03)00150-1

    authors: Ichihashi M,Ueda M,Budiyanto A,Bito T,Oka M,Fukunaga M,Tsuru K,Horikawa T

    更新日期:2003-07-15 00:00:00

  • Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model.

    abstract::The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(86)90129-0

    authors: Mast TJ,Cukierski MA,Nau H,Hendrickx AG

    更新日期:1986-05-01 00:00:00

  • Delta(9)-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling.

    abstract::We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2007.12.019

    authors: Takeda S,Yamaori S,Motoya E,Matsunaga T,Kimura T,Yamamoto I,Watanabe K

    更新日期:2008-03-12 00:00:00

  • Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic functions.

    abstract::The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(97)03662-7

    authors: Santoni G,Cantalamessa F,Mazzucca L,Romagnoli S,Piccoli M

    更新日期:1997-07-11 00:00:00

  • The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926).

    abstract:OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2005.09.014

    authors: Kilic B,Kruse M,Stahlmann R

    更新日期:2006-01-20 00:00:00

  • Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.

    abstract::The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompani...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(89)90215-1

    authors: Chauhan SS,Singh SK,Misra UK

    更新日期:1989-05-31 00:00:00

  • Effects of calcium and magnesium acetates on tissue distribution of carcinogenic doses of cadmium chloride in Wistar rats.

    abstract::Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of th...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(85)90173-8

    authors: Kasprzak KS,Poirier LA

    更新日期:1985-03-15 00:00:00

  • Teratogenic effects of various di-n-butyltins with different anions and butyl(3-hydroxybutyl)tin dilaurate in rats.

    abstract::In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(93)90039-u

    authors: Noda T,Morita S,Baba A

    更新日期:1993-12-31 00:00:00

  • Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol.

    abstract::Deoxynivalenol (DON) is one of the major mycotoxic contaminants of grains, which causes reduced weight gain in pigs. The cytotoxicity of DON to porcine hepatocytes was examined in this study. DON was added at the final concentration of 100, 10, 1, 0.1 or 0.01 microg/ml to the medium of primary cultured hepatocytes. Ce...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2004.07.001

    authors: Mikami O,Yamamoto S,Yamanaka N,Nakajima Y

    更新日期:2004-11-15 00:00:00

  • miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN.

    abstract::Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2013.02.014

    authors: Yang SM,Huang C,Li XF,Yu MZ,He Y,Li J

    更新日期:2013-04-05 00:00:00

  • Role for membrane remodeling in cell death: implication for health and disease.

    abstract::Recently it has become clear that exposure to xenobiotics may result in various forms of cell death; not only passive cell deaths like necrosis, or programmed cell deaths such as apoptosis, but also regulated necrosis, autophagy, senescence, or mitotic catastrophe. Complex cell signaling networks influence the process...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tox.2012.12.014

    authors: Tekpli X,Holme JA,Sergent O,Lagadic-Gossmann D

    更新日期:2013-02-08 00:00:00

  • Chloral hydrate enhances ethanol-induced inhibition of methanol oxidation in mice.

    abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(98)00108-5

    authors: Faci A,Plaa GL,Sharkawi M

    更新日期:1998-11-02 00:00:00

  • Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance.

    abstract::We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-483x(03)00291-9

    authors: Henning W,Stürzbecher HW

    更新日期:2003-11-15 00:00:00

  • Investigations in bitro and in vivo, of the effects of disulfiram (Antabuse) on human lymphocyte chromosomes.

    abstract::Pilinskaya showed that the fungicide ziram induced chrocosome aberrations in the lymphocytes of exposed industrial workers and also in lymphocyte cultures treated in vitro. Ziram is chemically similar to the drug Antabuse (disulfirm) which is used in the treatment of alcoholics. To establish whether disulfirm can also...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(75)90055-4

    authors: Lilly LJ

    更新日期:1975-07-01 00:00:00

  • Effect of succinimide ring modification on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats.

    abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) has proven to be an effective experimental agricultural fungicide. However, NDPS produces marked nephrotoxicity in Sprague-Dawley and Fischer 344 rats. The purpose of this study was to determine the importance of an intact, unsubstituted succinimide ring for acute NDPS-induced ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(85)90113-1

    authors: Yang DJ,Richmond CD,Teets VJ,Brown PI,Rankin GO

    更新日期:1985-10-01 00:00:00

  • Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

    abstract::Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2006.12.009

    authors: Landvik NE,Gorria M,Arlt VM,Asare N,Solhaug A,Lagadic-Gossmann D,Holme JA

    更新日期:2007-03-07 00:00:00

  • Determination of miosis threshold from whole-body vapor exposure to sarin in African green monkeys.

    abstract::We determined the threshold concentration of sarin vapor exposure producing miosis in African green monkeys (Chlorocebus aethiops). Monkeys (n=8) were exposed to a single concentration of sarin (0.069-0.701mg/m3) for 10min. Changes in pupil size were measured from photographs taken before and after the exposure. Sarin...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2007.11.004

    authors: Genovese RF,Benton BJ,Oubre JL,Fleming PJ,Jakubowski EM,Mioduszewski RJ

    更新日期:2008-02-28 00:00:00

  • Chemical sensitivity: symptom, syndrome or mechanism for disease?

    abstract::Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/0300-483x(96)03393-8

    authors: Miller CS

    更新日期:1996-07-17 00:00:00

  • Time-course of toxicity of reactive sulfonamide metabolites.

    abstract::It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(94)02900-f

    authors: Rieder MJ,Krause R,Bird IA

    更新日期:1995-01-06 00:00:00

  • Effects of S-adenosylmethionine on intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat.

    abstract::We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA(10) or 20 mg/kg per day-CyA(20) for 4 weeks) in rats. CyA treatment reduced the liver content of total gluta...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2004.02.030

    authors: Palomero J,Galán AI,Muñoz ME,González-Gallego J,Tuñón MJ,Jiménez R

    更新日期:2004-07-15 00:00:00

  • Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension.

    abstract::Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2011.03.018

    authors: Nemmar A,Zia S,Subramaniyan D,Fahim MA,Ali BH

    更新日期:2011-07-11 00:00:00

  • Novel phototoxicity assay using human embryonic stem cell-derived retinal pigment epithelial cells.

    abstract::Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chemical phototoxicity using mouse 3T3 fibroblasts. However, the high rat...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2017.01.003

    authors: Mori T,Higashi K,Nakano T,Ando S,Kuwahara A,Suzuki N,Saito K

    更新日期:2017-03-01 00:00:00

  • Sodium benzoate attenuates D-serine induced nephrotoxicity in the rat.

    abstract::D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules. The onset is rapid, occurring within 3-4 h and accompanied by proteinuria, glucosuria and aminoaciduria. The metabolism of D-serine by D-amino acid oxidase (D-AAO) may be involved in the mechanism of toxicity. D-AAO is locali...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2004.08.008

    authors: Williams RE,Lock EA

    更新日期:2005-02-01 00:00:00

  • Alteration of an essential NK cell signaling pathway by low doses of tributyltin in human natural killer cells.

    abstract::Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an int...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2006.05.002

    authors: Aluoch AO,Odman-Ghazi SO,Whalen MM

    更新日期:2006-07-25 00:00:00

  • Acute cardiovascular toxicity of trazodone, etoperidone and imipramine in rats.

    abstract::The cardiovascular effects of trazodone, a broad-spectrum antidepressant and its analogue etoperidone, were compared with imipramine, following intravenous infusion in rats. Their effects on electrocardiogram and blood pressure were simultaneously recorded until cardiac arrest. Hypotension was the primary effect of tr...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(78)90065-3

    authors: Lisciani R,Baldini A,Benedetti D,Campana A,Barcellona PS

    更新日期:1978-06-01 00:00:00

  • Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats.

    abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2015.08.001

    authors: Tanaka T,Mizukami S,Hasegawa-Baba Y,Onda N,Sugita-Konishi Y,Yoshida T,Shibutani M

    更新日期:2015-10-02 00:00:00

  • In vivo modulation of muscarine receptors in rat brain by acute lead intoxication.

    abstract::In our experiments on acutely lead exposed rats we observed a marked increase (a 2-fold or 3-fold increase with 30 mg/kg or 60 mg/kg lead acetate, respectively) in [3H]quinuclidinyl benzilate [( 3H]QNB) specific binding to muscarine receptors from striatum and cortex, without any change in receptor affinity. Muscarine...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(84)90005-2

    authors: Moingeon P,Bidart JM,Alberici GF,Boudène C,Bohuon C

    更新日期:1984-05-14 00:00:00

  • Prophylactic potential of memantine against soman poisoning in rats.

    abstract:BACKGROUND:Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an a...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2019.01.012

    authors: Stojiljković MP,Škrbić R,Jokanović M,Bokonjić D,Kilibarda V,Vulović M

    更新日期:2019-03-15 00:00:00

  • Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos.

    abstract::The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2010.05.012

    authors: Weigt S,Huebler N,Braunbeck T,von Landenberg F,Broschard TH

    更新日期:2010-09-10 00:00:00

  • Effects of amiodarone administration during pregnancy in Fischer 344 rats.

    abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(91)90085-f

    authors: Hill DA,Reasor MJ

    更新日期:1991-01-01 00:00:00