Abstract：
:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of cosmetics were discussed in depth.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Rogiers V,Benfenati E,Bernauer U,Bodin L,Carmichael P,Chaudhry Q,Coenraads PJ,Cronin MTD,Dent M,Dusinska M,Ellison C,Ezendam J,Gaffet E,Galli CL,Goebel C,Granum B,Hollnagel HM,Kern PS,Kosemund-Meynen K,Ouédraogo G,doi
10.1016/j.tox.2020.152421subject
Has Abstractpub_date
2020-04-30 00:00:00pages
152421eissn
0300-483Xissn
1879-3185pii
S0300-483X(20)30060-3journal_volume
436pub_type
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