Anaphylactic reactions--value of skin and provocation tests.

abstract：:Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four group...

journal_title：Toxicology

authors： Zhu Y,Hu C,Zheng P,Miao L,Yan X,Li H,Wang Z,Gao B,Li Y

更新日期：2016-08-10 00:00:00

abstract：:Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...

journal_title：Toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-29 00:00:00

abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...

journal_title：Toxicology

authors： Ljunggren SA,Iggland M,Rönn M,Lind L,Lind PM,Karlsson H

更新日期：2016-03-10 00:00:00

abstract：:Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident. ...

journal_title：Toxicology

authors： Gupta S,Pandey SD,Misra V,Viswanathan PN

更新日期：1986-02-01 00:00:00

abstract：:4-Amino-2,6-dichlorophenol (ADCP) is a potent acute nephrotoxicant in vivo inducing prominent renal corticomedullary necrosis. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. The purpose of this study was to examine the ability of antioxidants...

journal_title：Toxicology

authors： Rankin GO,Hong SK,Anestis DK,Ball JG,Valentovic MA

更新日期：2008-03-12 00:00:00

abstract：:The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...

journal_title：Toxicology

authors： Muruganandan S,Lal J,Gupta PK

更新日期：2005-11-05 00:00:00

abstract：:Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS)....

journal_title：Toxicology

authors： Boles JW,Klaassen CD

更新日期：2000-04-20 00:00:00

abstract：:The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation ...

journal_title：Toxicology

authors： Ema M,Kurosaka R,Amano H,Ogawa Y

更新日期：1995-02-27 00:00:00

abstract：:The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...

journal_title：Toxicology

authors： Leist M,Ayrton AD,Ioannides C

更新日期：1992-01-01 00:00:00

abstract：:Toxicity and other relevant data for 30 organophosphate pesticides were evaluated to suggest inhalation occupational exposure limits (OELs), and to support development of a risk assessment strategy for organophosphates in general. Specifically, the value of relative potency analysis and the predictability of inhalatio...

journal_title：Toxicology

authors： Storm JE,Rozman KK,Doull J

更新日期：2000-09-07 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:The cardiovascular toxin allylamine (3-aminopropene) has been shown to concentrate in elastic and muscular tissues. In this study the 14C-moiety of [14C]allylamine was traced in aortas of adult Sprague-Dawley rats after intravenously injecting 30 microCi of [14C]allylamine (spec. act. = 0.4 mCi/mM). At 5, 10, 15 and 2...

journal_title：Toxicology

authors： Hysmith RM,Boor PJ

更新日期：1985-06-14 00:00:00

abstract：:Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...

journal_title：Toxicology

authors： Delaney B,Kaminski NE

更新日期：1993-12-15 00:00:00

abstract：:Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...

journal_title：Toxicology

authors： Chitra KC,Latchoumycandane C,Mathur PP

更新日期：2003-03-14 00:00:00

abstract：:Zearalenone (ZEN) is a non-steroidal oestrogenic mycotoxin produced by several Fusarium species growing on cereals. ZEN and its metabolites bind to human oestrogen receptors and hence display oestrogenic and anabolic properties. Several lines of investigation suggest that ZEN may be genotoxic in vivo. ZEN damages DNA ...

journal_title：Toxicology

authors： Abid-Essefi S,Baudrimont I,Hassen W,Ouanes Z,Mobio TA,Anane R,Creppy EE,Bacha H

更新日期：2003-11-05 00:00:00

abstract：:To evaluate hydroperoxide generation as a potential mechanism of cyanide neurotoxicity, mice were treated with KCN (7 mg/kg, subcutaneously (s.c.)) and the level of lipid peroxidation (expressed as conjugated dienes) was measured later in various organs. Brain showed elevated conjugated diene levels after cyanide but ...

journal_title：Toxicology

authors： Ardelt BK,Borowitz JL,Maduh EU,Swain SL,Isom GE

更新日期：1994-04-18 00:00:00

abstract：:The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...

journal_title：Toxicology

authors： Trimble EJ

更新日期：1996-12-31 00:00:00

abstract：:Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...

journal_title：Toxicology

authors： Božinović K,Nestić D,Centa UG,Ambriović-Ristov A,Dekanić A,de Bisschop L,Remškar M,Majhen D

更新日期：2020-11-01 00:00:00

abstract：:Induction of oxidative stress by 2,4-dichlorophenoxyacetic acid (2,4-D) both as a pure compound and in commercial formulation was investigated during early pregnancy in mice. Pregnant animals were exposed to increasing doses of the herbicide (0.01, 0.1 and 100mg/kg/d) during gestation days 0-9, after which animals wer...

journal_title：Toxicology

authors： Dinamarca VM,Hidalgo ME,Cavieres MF

更新日期：2007-07-31 00:00:00

abstract：:Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...

journal_title：Toxicology

authors： Takeda S,Yamamoto I,Watanabe K

更新日期：2009-05-02 00:00:00

abstract：:Recent Canadian research efforts have been directed towards the development of a reactive skin decontaminant (RSD) lotion active against classical nerve agents and mustard. The formulation presently under study consists of a 1.25 molal solution of potassium 2,3-butanedione monoximate (KBDO) in polyethylene glycol meth...

journal_title：Toxicology

authors： Sawyer TW,Parker D,Thomas N,Weiss MT,Bide RW

更新日期：1991-05-01 00:00:00

abstract：:Methylcyclopentadienyl manganese tricarbonyl (MMT) is an effective inhibitor of mitochondrial respiration associated with NAD+-linked substrates. At concentrations which inhibit glutamate-malate oxidation (over 80% inhibition) succinate and tetramethylphenylenediamine (TMPD)-ascorbate are inhibited less than 25%. MMT ...

journal_title：Toxicology

authors： Autissier N,Dumas P,Brosseau J,Loireau A

更新日期：1977-02-01 00:00:00

abstract：:Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...

journal_title：Toxicology

authors： Hinoshita F,Hardin JA,Sherr DH

更新日期：1992-01-01 00:00:00

abstract：:Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures...

journal_title：Toxicology

authors： Abdullah L,Evans JE,Joshi U,Crynen G,Reed J,Mouzon B,Baumann S,Montague H,Zakirova Z,Emmerich T,Bachmeier C,Klimas N,Sullivan K,Mullan M,Ait-Ghezala G,Crawford F

更新日期：2016-11-30 00:00:00

abstract：:The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices o...

journal_title：Toxicology

authors： Gurer-Orhan H,Sabir HU,Ozgüneş H

更新日期：2004-02-15 00:00:00

abstract：:The coumarin 7-hydroxylase of mice (Coh, CYP2A5) is known to be highly selectively inducible by both a set of heavy metals such as cobalt, indium and cerium and a variety of organic nitrogen-containing heteroaromatic compounds such as 3-amino-1,2,4-triazole, pyrazine and pyrazole. The investigations presented reveal t...

journal_title：Toxicology

authors： Emde B,Tegtmeier M,Hahnemann B,Legrum W

更新日期：1996-04-15 00:00:00

abstract：:The usefulness of cDNA-directed expression of human hepatic P450s in yeast for the in vitro study of drug metabolism is emphasized. The major advantages of yeast expression are: (i) relatively high yields of heterologous P450 (approximately 5-10 nmol/l of culture medium) can be obtained; (ii) the expressed P450s are d...

journal_title：Toxicology

authors： Renaud JP,Peyronneau MA,Urban P,Truan G,Cullin C,Pompon D,Beaune P,Mansuy D

更新日期：1993-10-05 00:00:00

abstract：:An experimental approach was taken to the question of dose-response curves for chemical carcinogenesis, using DNA damage as a biomarker. Female rats were give 13 different doses of 1,2-dimethylhydrazine (from 1.4 to 135,000 micrograms/kg) and the subsequent hepatic DNA damage was determined by the alkaline elution tec...

journal_title：Toxicology

authors： Kitchin KT,Brown JL

更新日期：1996-12-02 00:00:00

abstract：:Fusarenon-X (FX), a trichothecene mycotoxin, is well known to be cytotoxic to mammalian cells. Our previous study revealed that FX induced apoptosis in mouse thymocytes both in vivo and in vitro. We investigated the mode of apoptosis induced by FX using HL-60 cell culture. When FX at a final concentration of 0.5 micro...

journal_title：Toxicology

authors： Miura K,Aminova L,Murayama Y

更新日期：2002-03-20 00:00:00

abstract：:High-throughput in vitro toxicity screening provides an efficient way to identify potential biological targets for environmental and industrial chemicals while conserving limited testing resources. However, reliance on the nominal chemical concentrations in these in vitro assays as an indicator of bioactivity may misr...

journal_title：Toxicology

authors： Wetmore BA

更新日期：2015-06-05 00:00:00