Abstract：
:The coumarin 7-hydroxylase of mice (Coh, CYP2A5) is known to be highly selectively inducible by both a set of heavy metals such as cobalt, indium and cerium and a variety of organic nitrogen-containing heteroaromatic compounds such as 3-amino-1,2,4-triazole, pyrazine and pyrazole. The investigations presented reveal that inorganic divalent tin has to be included in the list of selective inducers. Pretreatment of NMRI-mice with 50 mg SnCl2/kg body weight, daily for 2 days, increases the coumarin hydroxylation 40- and 20-fold in the kidney and liver, respectively. So far, the inducing potency of tin chloride is higher than that of the agents already known. The diagnostic inhibitor metyrapone strongly inhibits the coumarin model reaction. In the kidneys tin generates an almost pure fraction of a cytochrome P450 isozyme catalyzing the metabolism of coumarins, as inhibition experiments reveal.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Emde B,Tegtmeier M,Hahnemann B,Legrum Wdoi
10.1016/0300-483x(95)03285-nsubject
Has Abstractpub_date
1996-04-15 00:00:00pages
73-8issue
1-2eissn
0300-483Xissn
1879-3185pii
0300-483X(95)03285-Njournal_volume
108pub_type
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