Abstract：
:The effects of D- and L-T3 were compared in male SK & F Wistar rats to define overall effects on the 'pituitary-thyroid-liver axis' at high doses. After in vivo administration of L-T3 (up to 1 mg/kg orally, or up to 0.1 mg/kg subcutaneously) serum TSH and T4 were decreased in a dose-related manner. Similarly, following in vivo exposure to L-T3, both basal and TRH-stimulated TSH output from isolated superfused pituitary glands was decreased, but only the latter was affected by direct in vitro exposure to L-T3.D-T3 had between 1% and 10% the activity of L-T3 in decreasing these parameters both in vivo and in vitro. In contrast, both enantiomers increased liver and kidney deiodinase activity to approximately the same extent, presumably as a compensatory response to clear hormone from the body. These observations indicate that, following treatment with L- or D-T3 by oral gavage for 14 days, the 'no effect' dose (i.e. the dose which did not significantly decrease serum TSH concentrations as compared with controls) for L-T3 was below 0.01 mg/kg whereas that for D-T3 was 0.1 mg/kg.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Jones CA,Brown CG,Dickens TA,Atterwill CKdoi
10.1016/0300-483x(88)90108-4subject
Has Abstractpub_date
1988-03-01 00:00:00pages
273-84issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(88)90108-4journal_volume
48pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Long-term exposure to pharmacological agents can select for cells that overexpress efflux transporters. We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.09.003
更新日期：2011-12-18 00:00:00
abstract：:A fixed combination of the three components, fructose, cyclosporin A and trifluoperazine (FCAT), was found to protect in the late stage of paracetamol-induced liver cell injury both in vivo and in an in vivo/in vitro system. Rats pre-induced with phenobarbitone were given a paracetamol dose of 1 g/kg i.p. The combinat...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03262-e
更新日期：1996-03-18 00:00:00
abstract：:Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four group...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.07.014
更新日期：2016-08-10 00:00:00
abstract：:The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(79)80003-7
更新日期：1979-05-01 00:00:00
abstract：:A qualitative assessment of developmental toxicity within a series of 12 structurally related compounds, 11 of which were active dopamine mimetics and one was inactive, was conducted in rats treated orally by gavage during the major period of organogenesis. Doses were chosen where possible to be equipotent in terms of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90189-l
更新日期：1992-12-04 00:00:00
abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90056-m
更新日期：1990-06-01 00:00:00
abstract：:Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.01.024
更新日期：2009-05-02 00:00:00
abstract：:The susceptibility to hepatocellular carcinoma (HCC) varies greatly within human populations in response to environmental risk agents. The mechanisms underlying differential susceptibility are still largely unknown and need to be clarified to improve HCC chemoprevention and therapeutic treatment. Inbred rodent strains...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.09.013
更新日期：2008-12-05 00:00:00
abstract：:The therapy of organophosphorus compound (OP) poisoning is still a challenge to clinical toxicologists. To alleviate peripheral respiratory failure oximes, e.g. obidoxime and pralidoxime, are used to reactivate inhibited acetylcholinesterase (AChE) with the intention to restore the disturbed neuromuscular function. In...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.04.002
更新日期：2010-06-04 00:00:00
abstract：:The tissue uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in a mouse model using the common human virus Coxsackievirus B3 (CB3), adapted here to the mouse. Male A/J-mice were infected with the CB3 virus and subsequently, on days 4 and 7 of the infection, injected with 0.5 microCi [14...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90202-x
更新日期：1994-05-31 00:00:00
abstract：:Mitochondrial fission, fusion, and mitophagy are interlinked processes that regulate mitochondrial shape, number, and size, as well as metabolic activity and stress response. The fundamental importance of these processes is evident in the fact that mutations in fission (DRP1), fusion (MFN2, OPA1), and mitophagy (PINK1...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.05.018
更新日期：2017-07-15 00:00:00
abstract：:Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisatio...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90192-h
更新日期：1992-12-04 00:00:00
abstract：:The effects of isoflurane, 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, on the oxidative metabolism of halothane to produce trifluoroacetic acid (TFA) and on the reductive metabolism of halothane to produce chlorodifluoroethylene (CDE) and chlorotrifluoroethane (CTE) in liver microsomes of guinea pig were exami...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03154-8
更新日期：1995-12-15 00:00:00
abstract：:Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.11.005
更新日期：2014-01-06 00:00:00
abstract：:Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity may vary widely with species and strain, we examined the effect of te...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03544-5
更新日期：1997-01-15 00:00:00
abstract：:Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(99)00199-7
更新日期：2000-04-03 00:00:00
abstract：:Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90202-8
更新日期：1988-11-14 00:00:00
abstract：:In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two di...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00373-6
更新日期：2002-09-30 00:00:00
abstract：:The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, ind...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2007.11.021
更新日期：2008-03-20 00:00:00
abstract：:The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00129-x
更新日期：2003-08-01 00:00:00
abstract：:Rats poisoned with one LD50 of thiopental or amytal are shown to increase oxygen consumption when intraperitoneally given sucinate, malate, citrate, alpha-ketoglutarate, dimethylsuccinate or glutamate (the Krebs cycle intermediates or their precursors) but not when given glucose, pyruvate, acetate, benzoate or nicotin...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.05.005
更新日期：2004-10-01 00:00:00
abstract：:Natural antioxidants like catechin are now known to have a modulatory role on physiological functions and biotransformation reactions involved in the detoxification process, thereby affording protection from toxic metabolic actions of xenobiotics. Reactive oxygen intermediates have been demonstrated to play an etiolog...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.05.009
更新日期：2006-08-15 00:00:00
abstract：:A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00151-6
更新日期：1999-02-15 00:00:00
abstract：:Silver nanoparticles (AgNPs) are widely utilized in various consumer products and medical devices, especially due to their antimicrobial properties. However, several studies have associated these particles with toxic effects, such as inflammation and oxidative stress in vivo and cytotoxic and genotoxic effects in vitr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.09.014
更新日期：2013-11-08 00:00:00
abstract：:It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02900-f
更新日期：1995-01-06 00:00:00
abstract：:Use of the fluoroquinolone antibiotic trovafloxacin (TVX) was restricted due to idiosyncratic, drug-induced liver injury (IDILI). Previous studies demonstrated that tumor necrosis factor-alpha (TNF) and TVX interact to cause death of hepatocytes in vitro that was associated with prolonged activation of c-Jun N-termina...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.03.002
更新日期：2015-05-04 00:00:00
abstract：OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.09.014
更新日期：2006-01-20 00:00:00
abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90154-k
更新日期：1993-07-11 00:00:00
abstract：:The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrome...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00202-x
更新日期：2000-08-07 00:00:00
abstract：:A flow-through rat tracheal implant system is described which permits the quantitative and repetitive exposure of respiratory epithelia to test gaseous substances. To investigate the acute toxicity of formaldehyde gas with this new system, open-ended rat tracheal implants were exposed to the gas for 1 h twice a week f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90142-2
更新日期：1984-04-16 00:00:00
