Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats.

abstract：:Sodium fluoride (NaF) is widely used for the treatment of dental caries and dentin hypersensitivity. However, its pro-apoptotic effect on odontoblasts may lead to harmful side-effects. The purpose of this study was to evaluate the pro-apoptotic effects of NaF in odontoblasts and elucidate the possible underlying molec...

journal_title：Toxicology

authors： Li P,Xue Y,Zhang W,Teng F,Sun Y,Qu T,Chen X,Cheng X,Song B,Luo W,Yu Q

更新日期：2013-06-07 00:00:00

abstract：:This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...

journal_title：Toxicology

authors： van Dam RA,Humphrey CL,Martin P

更新日期：2002-12-27 00:00:00

abstract：:Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...

journal_title：Toxicology

authors： Buck J,Hattersley S,Kimber I

更新日期：2010-12-30 00:00:00

abstract：:Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...

journal_title：Toxicology

authors： Seemayer NH,Manojlovic N

更新日期：1980-01-01 00:00:00

abstract：:The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO4, K2Cr2O7, CoCl2, Na2PtCl6 and BeSO4, salts of metals which have all been associated with allergic contact dermatitis and either...

journal_title：Toxicology

authors： Mandervelt C,Clottens FL,Demedts M,Nemery B

更新日期：1997-06-06 00:00:00

abstract：:(1) Following the administration of the highly toxic agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant mice, exceedingly low concentrations of this substance were found in the embryo and fetus between gestational days 11 and 18 (between 0.04 and 0.14% of the maternal dose/g tissue). (2) Tissue levels of tCD...

journal_title：Toxicology

authors： Nau H,Bass R

更新日期：1981-01-01 00:00:00

abstract：:The oxidation of guanine to 8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most abundant and best studied oxidative DNA lesions and is commonly used as a biomarker for oxidative stress. Over the last decades, various methods for the detection of DNA oxidation products have been established and optimized. However, so...

journal_title：Toxicology

authors： Müller N,Moreno-Villanueva M,Fischbach A,Kienhöfer J,Martello R,Dedon PC,Ullrich V,Bürkle A,Mangerich A

更新日期：2013-08-09 00:00:00

abstract：:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...

journal_title：Toxicology

authors： Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska A

更新日期：1996-04-15 00:00:00

abstract：:Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...

journal_title：Toxicology

authors： Travacio M,María Polo J,Llesuy S

更新日期：2000-09-07 00:00:00

abstract：:Clarification of the key regulatory steps that lead to nuclear factor-kappa B (NF-kappaB) under cellular and pathological conditions is very important. The action of p38 mitogen-activated protein kinase (MAPK) on the upstream of NF-kappaB activation remains controversial. To examine this issue using an in vivo lung in...

journal_title：Toxicology

authors： Kim HJ,Lee HS,Chong YH,Kang JL

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:We investigated the potential dose related apoptotic effect of subchronic administration of the alkylating chemotherapeutic agent ifosfamide in different sites of the small and large rabbit intestine. MATERIALS AND METHODS:Twenty New Zealand White rabbits received intravenously every week, for 10 weeks, 0 (g...

journal_title：Toxicology

authors： Ypsilantis P,Tentes L,Assimakopoulos SF,Kortsaris A,Scopa CD,Pitiakoudis M,Simopoulos C

更新日期：2004-08-05 00:00:00

abstract：PURPOSE:1-Bromopropane (1-BP) intoxication is associated with depression and cognitive and memory deficits. The present study tested the hypothesis that 1-BP suppresses neurogenesis in the dentate gyrus, which is involved in higher cerebral function, in adult rats. METHODS:Four groups of 12 male Wistar rats were expos...

journal_title：Toxicology

authors： Zhang L,Nagai T,Yamada K,Ibi D,Ichihara S,Subramanian K,Huang Z,Mohideen SS,Naito H,Ichihara G

更新日期：2013-02-08 00:00:00

abstract：:Female mice were given nutrient-sufficient, purified diets containing cadmium at either 0.25, 5, or 50 ppm, as described in the accompanying publication. One-half of the females were bred for 6 consecutive 42-day rounds of pregnancy/lactation (PL mice); remaining females were non-pregnant controls (NP mice). PL mice a...

journal_title：Toxicology

authors： Bhattacharyya MH,Whelton BD,Peterson DP,Carnes BA,Guram MS,Moretti ES

更新日期：1988-07-01 00:00:00

abstract：:Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antidepressant and possesses a highly selective norepinephrine reu...

journal_title：Toxicology

authors： Jan CR,Su JA,Teng CC,Sheu ML,Lin PY,Chi MC,Chang CH,Liao WC,Kuo CC,Chou CT

更新日期：2013-02-08 00:00:00

abstract：:This paper looks at toxicology digital sources produced and available in the United Kingdom (UK). It includes products aggregating a number of sources, which may include information from other countries, and for the convenience of the reader and information seeker these have also been described. ...

journal_title：Toxicology

authors： Pantry S

更新日期：2003-08-21 00:00:00

abstract：:The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) on hepatic, renal and small intestinal drug-metabolizing enzyme activities, hepatic reduced glutathione content and urinary excretion of thioethers were studied in the rat. A single i.p. dose of Penfenate (500 mg/kg) decreased the body weig...

journal_title：Toxicology

authors： Mäntylä E,Ahotupa M,Hietanen E,Vainio H

更新日期：1983-07-01 00:00:00

abstract：:The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...

journal_title：Toxicology

authors： Mollière M,Foth H,Kahl R,Kahl GF

更新日期：1987-08-01 00:00:00

abstract：:Butachlor is a systemic herbicide widely applied on rice, tea, wheat, beans and other crops; however, it concurrently exerts toxic effects on beneficial organisms like earthworms, aquatic invertebrates and other non-target animals including humans. Owing to the associated risk to humans, this chloroacetanilide class o...

journal_title：Toxicology

authors： Dwivedi S,Saquib Q,Al-Khedhairy AA,Musarrat J

更新日期：2012-12-08 00:00:00

abstract：:Subchronic exposure to arsenic is associated with alteration of glucose homeostasis. Arsenic treatment (as sodium arsenite) of male Wistar rats (weighing 130-150 g) at a dose of 5.55 mg kg(-1) body weight (equivalent to 35% of LD(50)) (i.p.) per day for a period of 30 days produced hypoglycemia, with associated increa...

journal_title：Toxicology

authors： Pal S,Chatterjee AK

更新日期：2005-03-01 00:00:00

abstract：:Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...

journal_title：Toxicology

authors： Ren Z,Chen S,Qing T,Xuan J,Couch L,Yu D,Ning B,Shi L,Guo L

更新日期：2017-12-01 00:00:00

abstract：:There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...

journal_title：Toxicology

authors： Tomita M,Katsuyama H,Watanabe Y,Okuyama T,Fushimi S,Ishikawa T,Nata M,Miyamoto O

更新日期：2014-05-07 00:00:00

abstract：:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...

journal_title：Toxicology

authors： Rogiers V,Benfenati E,Bernauer U,Bodin L,Carmichael P,Chaudhry Q,Coenraads PJ,Cronin MTD,Dent M,Dusinska M,Ellison C,Ezendam J,Gaffet E,Galli CL,Goebel C,Granum B,Hollnagel HM,Kern PS,Kosemund-Meynen K,Ouédraogo G,

更新日期：2020-04-30 00:00:00

abstract：:Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse. Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner. MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/k...

journal_title：Toxicology

authors： Wormser U,Calp D

更新日期：1988-12-30 00:00:00

abstract：:Chronic ethanol intake affects various organ systems of the body. The present study evaluated modifications of fatty acid concentrations both in brain and striated skeletal muscles of rats genetically selected for voluntary high ethanol intake. Three groups of rats were tracked for 10 weeks of access to ethanol only a...

journal_title：Toxicology

authors： Berrettini M,Fedeli D,Falcioni G,Bevilacqua C,Massi M,Polidori C

更新日期：2004-07-01 00:00:00

abstract：:Long-term exposure to pharmacological agents can select for cells that overexpress efflux transporters. We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced...

journal_title：Toxicology

authors： Vallet CM,Marquez B,Nhiri N,Anantharajah A,Mingeot-Leclercq MP,Tulkens PM,Lallemand JY,Jacquet E,Van Bambeke F

更新日期：2011-12-18 00:00:00

abstract：:As vaccines are undoubtedly classified as pharmaceuticals, they have to be submitted to strict non-clinical safety evaluation. The context of their prophylactic use requires that every effort is made to ensure their safe use. Their safety evaluation is complex as they act through a multistage mechanism in which the va...

journal_title：Toxicology

authors： Verdier F

更新日期：2002-05-15 00:00:00

abstract：:A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alky...

journal_title：Toxicology

authors： Gandy J,Ali FA,Hasegawa L,Imamura T

更新日期：1984-07-01 00:00:00

abstract：:Increased antigen-specific IgE expression is a hallmark of the allergic response in mice. IgG1 may also be involved. Co-injection of mice with diesel exhaust particles (DEP) and ovalbumin three times over a 2 week period lead to a rapid and marked elevation of ovalbumin-specific IgE, IgG1 and also IgG2a, compared with...

journal_title：Toxicology

authors： Heo Y,Saxon A,Hankinson O

更新日期：2001-02-28 00:00:00

abstract：:This paper introduces the special issue on quantitative in vitro-in vivo extrapolations (QIVIVE). It highlights important issues in the development of in vitro toxicology towards its implementation in toxicological risk assessment. ...

journal_title：Toxicology

authors： Blaauboer BJ

更新日期：2015-06-05 00:00:00

abstract：:Many scientists and doctors are not aware that the level of certainty for litigation purposes differs from that usually associated with scientific studies. Although the 0.05 probability level is commonly used in scientific studies ("beyond a reasonable doubt"), in U.S. civil litigation the diagnostic criteria is "more...

journal_title：Toxicology

authors： Singer R

更新日期：1988-05-01 00:00:00