NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma.

abstract：:Several types of pesticides, such as organophosphates, phenoxyacetic acid, and carbamate have a high risk of affecting human health, causing allergic rhinitis and bronchial asthma-like diseases. We used our long-term sensitization method and a local lymph node assay to examine the allergic reactions caused by several ...

journal_title：Toxicology

authors： Fukuyama T,Tajima Y,Ueda H,Hayashi K,Shutoh Y,Harada T,Kosaka T

更新日期：2009-07-10 00:00:00

abstract：:Since clotrimazole, known as an antifungal drug, exerts diverse actions on cellular functions, it is expected that clotrimazole can be used for other purposes. This antifungal drug protects the cells overloaded with Ca(2+) by A23187, a calcium ionophore. Therefore, the agent may prevent the cells from death induced by...

journal_title：Toxicology

authors： Oyama TM,Oyama TB,Oyama K,Matsui H,Horimoto K,Nishimura Y,Oyama Y

更新日期：2006-12-07 00:00:00

abstract：:Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...

journal_title：Toxicology

authors： Fan LQ,Brown-Borg H,Brown S,Westin S,Mode A,Corton JC

更新日期：2004-10-15 00:00:00

abstract：:4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names "Venus", "Bromo", "Erox", "XTC" or "Nexus". Concern has been raised because only little is known about its toxicity and metabolism in humans. In the present study we incubated 2C-B with human, monkey...

journal_title：Toxicology

authors： Carmo H,Hengstler JG,de Boer D,Ringel M,Remião F,Carvalho F,Fernandes E,dos Reys LA,Oesch F,de Lourdes Bastos M

更新日期：2005-01-05 00:00:00

abstract：:Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...

journal_title：Toxicology

authors： Toraason M,Clark J,Dankovic D,Mathias P,Skaggs S,Walker C,Werren D

更新日期：1999-10-29 00:00:00

abstract：:The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...

journal_title：Toxicology

authors： Hidalgo J,Armario A

更新日期：1987-07-01 00:00:00

abstract：:The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...

journal_title：Toxicology

authors： Weaver JL,Staten D,Swann J,Armstrong G,Bates M,Hastings KL

更新日期：2003-12-01 00:00:00

abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...

journal_title：Toxicology

authors： Ljunggren SA,Iggland M,Rönn M,Lind L,Lind PM,Karlsson H

更新日期：2016-03-10 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...

journal_title：Toxicology

authors： Park Y,Smith RD,Combs AB,Kehrer JP

更新日期：1988-11-14 00:00:00

abstract：:Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...

journal_title：Toxicology

authors： Yang SM,Huang C,Li XF,Yu MZ,He Y,Li J

更新日期：2013-04-05 00:00:00

abstract：:An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was ...

journal_title：Toxicology

authors： Meyer O,Hansen EV

更新日期：1975-11-01 00:00:00

abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...

journal_title：Toxicology

authors： Verstraeten SV

更新日期：2006-05-01 00:00:00

abstract：:We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone fo...

journal_title：Toxicology

authors： Funabashi H,Shima M,Kuwaki T,Hiroshima K,Kuriyama T

更新日期：2004-11-01 00:00:00

abstract：:The vapour pressures of 30 N-nitrosamines between 0 and 40 degrees C are calculated by means of well-known and experimentally proven formulae. The saturation concentration of the nitrosamines in air is presented as mmHg, ppm and mg/m3. For N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA) and N-nitrosopyrrol...

journal_title：Toxicology

authors： Klein RG

更新日期：1982-01-01 00:00:00

abstract：:Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and ...

journal_title：Toxicology

authors： Meyer JN,Leuthner TC,Luz AL

更新日期：2017-11-01 00:00:00

abstract：:Consequences of exposure of rats for 2 days or less to O3 at various concentrations between 0.12 and 0.96 ppm were measured using several assays performed on bronchoalveolar lavage fluid. Changes in apparent lung permeability were assessed by measurement of recovery of labelled bovine serum albumin in lung lavage flui...

journal_title：Toxicology

authors： Guth DJ,Warren DL,Last JA

更新日期：1986-08-01 00:00:00

abstract：:The effect of amyl nitrite on the erythrocytes of adult and cord hemoglobin was examined in vitro. This study revealed that amyl nitrite caused oxyhemoglobin to become oxidized to methemoglobin wherein a rectangular hyperbolic curve was generated as the reaction progressed. This curve consisted of a reactionary log ph...

journal_title：Toxicology

authors： Tarburton JP,Metcalf WK

更新日期：1985-07-01 00:00:00

abstract：:The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis were observed, but herein, analysis o...

journal_title：Toxicology

authors： Fiorito F,Ciarcia R,Granato GE,Marfe G,Iovane V,Florio S,De Martino L,Pagnini U

更新日期：2011-12-18 00:00:00

abstract：:The ability of 27 compounds to mediate depletion of glutathione (GSH) in a fortified liver microsome incubation via production of reactive metabolites generated by microsomal mono-oxygenase (MMO) metabolism has been studied. The majority of compounds tested of this type were positive in this assay, with the exception ...

journal_title：Toxicology

authors： Garle MJ,Fry JR

更新日期：1989-01-01 00:00:00

abstract：:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...

journal_title：Toxicology

authors： Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska A

更新日期：1996-04-15 00:00:00

abstract：:Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...

journal_title：Toxicology

authors： Kawamura Y,Hayashi H,Masumura K,Numazawa S,Nohmi T

更新日期：2014-10-03 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...

journal_title：Toxicology

authors： Delaney B,Kaminski NE

更新日期：1993-12-15 00:00:00

abstract：:CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male Fischer 344 rats were evaluated for splenic T- and B-lymphocyte populations, antibody-forming cell response to sheep red blood cells (sRBC), concanavalin A and pok...

journal_title：Toxicology

authors： Bleavins MR,de la Iglesia FA,McCay JA,White KL Jr,Munson AE

更新日期：1995-04-12 00:00:00

abstract：:The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...

journal_title：Toxicology

authors： Leist M,Ayrton AD,Ioannides C

更新日期：1992-01-01 00:00:00

abstract：:Many scientists and doctors are not aware that the level of certainty for litigation purposes differs from that usually associated with scientific studies. Although the 0.05 probability level is commonly used in scientific studies ("beyond a reasonable doubt"), in U.S. civil litigation the diagnostic criteria is "more...

journal_title：Toxicology

authors： Singer R

更新日期：1988-05-01 00:00:00

abstract：:Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS)....

journal_title：Toxicology

authors： Boles JW,Klaassen CD

更新日期：2000-04-20 00:00:00

abstract：:The mechanism of delta-aminolevulinate dehydratase (delta-ALA-D) inhibition by phenyl selenoacetylene in vitro was investigated in this study. Phenyl selenoacetylene (40-400 microM) inhibition of delta-aminolevulinate dehydratase from rat liver (low speed supernatant fraction, S1 fraction) was partially prevented by i...

journal_title：Toxicology

authors： Folmer V,Bolzan RC,Farina M,Zeni G,Nogueira CW,Emanuelli T,Rocha JB

更新日期：2005-01-31 00:00:00

abstract：:Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting c...

journal_title：Toxicology

authors： Wang Q,Shen JY,Zhang R,Hong JW,Li Z,Ding Z,Wang HX,Zhang JP,Zhang MR,Xu LC

更新日期：2020-05-30 00:00:00

abstract：:Bisphenol A (BPA) is a commonly used endocrine-disrupting chemical used as a component of polycarbonates plastics that has potential adverse effects on human health. Exposure to BPA during development has been implicated in memory deficits, but the mechanism of action underlying the effect is not fully understood. In ...

journal_title：Toxicology

authors： Wang C,Li Z,Han H,Luo G,Zhou B,Wang S,Wang J

更新日期：2016-02-03 00:00:00