Abstract:
:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as models compounds for investigating the mechanism of action of alkylating agents.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska Adoi
10.1016/0300-483x(95)03288-qsubject
Has Abstractpub_date
1996-04-15 00:00:00pages
125-8issue
1-2eissn
0300-483Xissn
1879-3185pii
0300-483X(95)03288-Qjournal_volume
108pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract:OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152668
更新日期:2020-12-28 00:00:00
abstract::The measurement of haemoglobin (Hb) adducts is an important tool for monitoring exposures to industrial chemicals such as ethylene, ethylene oxide and propylene oxide. The aim of the present study was to use this method to monitor occupational exposure to butadiene. The methodology was evaluated with Hb samples obtain...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03435-x
更新日期:1996-10-28 00:00:00
abstract::Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.10.002
更新日期:2017-12-01 00:00:00
abstract::The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these product...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.01.016
更新日期:2006-04-03 00:00:00
abstract::Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.001
更新日期:2010-01-12 00:00:00
abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152564
更新日期:2020-11-01 00:00:00
abstract::The effect of dose and duration of treatment with chromium on its distribution in certain vital organs and the blood of rats has been investigated. The accumulation of metal was highest in liver and kidneys, followed by testes, brain and blood and was rather more dependent on the dose than on the duration of exposure....
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.01.012
更新日期:2019-03-15 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) with molecular weight 278 are a group of PAHs that are mostly not covered by the current monitoring programs, despite their relative abundance in environmental samples and possible carcinogenicity. Although benzo[g]chrysene (BgChry) and dibenz[a,h]anthracene (DBahA) have been fo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.12.024
更新日期:2007-03-22 00:00:00
abstract::Aluminium (Al) oxyhydroxide (Alhydrogel®), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and rep...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.11.018
更新日期:2017-01-15 00:00:00
abstract::Consumption of edible oils contaminated with Argemone mexicana seed oil is known to cause various clinical manifestations. In the present study, the effect of dietary intake of argemone oil on histopathological changes, haematological indices and selected marker parameters of toxicity was investigated to observe the e...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90142-x
更新日期:1989-10-16 00:00:00
abstract::Salicylate has been found to be an inhibitor of fatty acid synthesis in isolated rat hepatocytes. Half-maximal inhibition of fatty acid synthesis occurs at approximately 2 mM. The inhibitory effect of salicylate on fatty acid synthesis is not relieve by the addition of acetate, suggesting that salicylate inhibits the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90060-9
更新日期:1982-01-01 00:00:00
abstract::We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00291-9
更新日期:2003-11-15 00:00:00
abstract::Chlorination of drinking water containing organic materials is known to generate toxic by-products. We suggested that such compounds may also be produced by interactions between chlorine and bacteria present in water. To confirm this hypothesis, a method based on RNA synthesis inhibition of HeLa S3 human cells in the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00317-6
更新日期:2000-11-16 00:00:00
abstract::The organophosphorus nerve agent soman is an irreversible cholinesterase (ChE) inhibitor that can produce long-lasting seizures and brain damage in which the neurotransmitters acetylcholine and glutamate are involved. These same neurotransmitters play key-roles in the auditory function. It was then assumed that explor...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.024
更新日期:2007-09-05 00:00:00
abstract::Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00597-8
更新日期:2003-03-14 00:00:00
abstract::The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five smal...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90070-0
更新日期:1975-09-01 00:00:00
abstract::Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.04.015
更新日期:2019-06-15 00:00:00
abstract::Subcutaneous administration of methyl isocyanate (MIC) in 0.5 LD50 and 1 LD50 doses in female rabbits resulted in significant changes in physiological, clinico-chemical and histological parameters. There was a fall in arterial blood pressure and cardioacceleration in both the 0.5 LD50 and 1 LD50 groups, while the resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90152-7
更新日期:1988-10-01 00:00:00
abstract::Utah Valley has provided an interesting and unique opportunity to evaluate the health effects of respirable particulate air pollution (PM10). Residents of this valley are predominantly nonsmoking members of the Church of Jesus Christ of Latter-day Saints (Mormons). The area has moderately high average PM10 levels with...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(96)03372-0
更新日期:1996-07-17 00:00:00
abstract::Prostaglandin E2 (PGE2) is a critical factor in the pathogenesis of dioxin-induced neonatal hydronephrosis. Since the PGE2 receptor has four subtypes, EP1 - EP4, this study was aimed to challenge the hypothesis that at least one of the four subtypes is responsible for the pathogenesis of dioxin-induced hydronephrosis....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.01.006
更新日期:2019-03-01 00:00:00
abstract::The hypothesis has been put forward that mutagenic polycyclic aromatic hydrocarbons which induce the P-450 I family of cytochromes, the major enzyme system responsible for their activation, are likely to be carcinogenic. In order to test this hypothesis, rats have been pretreated with a number of polycyclic aromatic h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90171-c
更新日期:1990-01-01 00:00:00
abstract::For the first time, kinetic parameters of the effect of tacrine, an anti-cholinesterase inhibitor of therapeutic potential in Alzheimer's disease has been studied on human retinal acetyl-cholinesterase (AChE). Tacrine inhibited the AChE activity in a concentration dependent manner, the IC(50) being about 45 nM. The Mi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00177-3
更新日期:2000-05-19 00:00:00
abstract::Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2009.11.008
更新日期:2010-11-28 00:00:00
abstract::No clinical data are available on the acute cutaneous toxicity of spin traps which are frequently used in combination with the electron paramagnetic resonance (EPR) technique for detection of free radicals and reactive oxygen/nitrogen species. The purpose of this study was to evaluate the acute dermatotoxicity of the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00284-5
更新日期:2000-10-26 00:00:00
abstract::Mature rats were dosed with T3 by different routes and dose-levels at either 0.1 mg/kg for 14 days s.c. (Group A), 1 mg/kg for 3 alternative days i.p. (Group B), 5 mg/kg for 14 days p.o. (Group C), or with propylthiouracil (PTU 50 mg/day for 14 days p.o.-Group D). Measurement of cerebellar and striatal NA+,K+-ATPase a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90075-8
更新日期:1987-01-01 00:00:00
abstract::Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90117-1
更新日期:1980-01-01 00:00:00
abstract::Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90151-4
更新日期:1992-11-01 00:00:00
abstract::The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.06.008
更新日期:2005-11-05 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) have the potential to interfere with the hormonal system and may negatively influence human health. Microarray analysis was used in this study to investigate differential gene expression in human peripheral blood cells (PBMCs) after in vitro exposure to EDCs. PBMCs, isolated from ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.10.019
更新日期:2013-01-07 00:00:00