In vivo and in vitro toxicity of newly synthesized monofunctional sulfur mustard derivatives.

Abstract:

:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as models compounds for investigating the mechanism of action of alkylating agents.

journal_name

Toxicology

journal_title

Toxicology

authors

Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska A

doi

10.1016/0300-483x(95)03288-q

subject

Has Abstract

pub_date

1996-04-15 00:00:00

pages

125-8

issue

1-2

eissn

0300-483X

issn

1879-3185

pii

0300-483X(95)03288-Q

journal_volume

108

pub_type

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