Mechanism of delta-aminolevulinate dehydratase inhibition by phenyl selenoacetylene involves its conversion to diphenyl diselenide.

abstract：:Bromate (BrO3-) is a rodent carcinogen that is formed as a drinking water ozone disinfection by-product and also used in some food and consumer products. Therefore, bromate is subject to assessment for its risk to humans. Because the selection of an appropriate model for conducting quantitative cancer risk assessment ...

journal_title：Toxicology

authors： Moore MM,Chen T

更新日期：2006-04-17 00:00:00

abstract：:The importance of dietary factors for prostate carcinogenesis has been proven by epidemiological studies of immigrants from Asia into the USA. Intake of foodstuffs rich in fat, including meat, is suggested to be a risk factor. Experimentally, while some studies demonstrated high fat intake to promote rat prostate carc...

journal_title：Toxicology

authors： Shirai T,Asamoto M,Takahashi S,Imaida K

更新日期：2002-12-27 00:00:00

abstract：:Recent epidemiological studies have reported associations between the consumption of chlorinated drinking water and various types of human cancer; in addition, exposure to chlorine (Cl-) in drinking water has been reported to suppress certain immune functions in laboratory animals. The current studies were conducted t...

journal_title：Toxicology

authors： French AS,Copeland CB,Andrews DL,Wiliams WC,Riddle MM,Luebke RW

更新日期：1998-01-16 00:00:00

abstract：:Microcystins are cyclic heptapeptide toxins produced by certain strains of Microcystis aeruginosa and microcystin-LR (MC-LR) is the most toxic among the 70 variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we investigated the microcystin-LR induced ...

journal_title：Toxicology

authors： Jayaraj R,Anand T,Rao PV

更新日期：2006-03-15 00:00:00

abstract：:Mechanisms responsible for resistance to Cd-induced testicular necrosis in inbred mice were investigated using strains resistant (A/J) or susceptible (129/J) to Cd-induced testicular damage. Cadmium accumulation was measured in testes of both strains 15 min, 30 min, 1 h, 2 h, 6 h, 12 h and 24 h after intravenous injec...

journal_title：Toxicology

authors： Chellman GJ,Shaikh ZA,Baggs RB

更新日期：1984-03-01 00:00:00

abstract：:To investigate the mechanism of hepatocarcinogenesis due to dicyclanil (DC), an insect growth regulator for sheep, histopathological and molecular biological analyses were performed in the liver of male ICR mice fed on a diet containing 1500 ppm of DC for 2 weeks (Experiment I; Exp. I). In gene expression analyses usi...

journal_title：Toxicology

authors： Moto M,Okamura M,Muto T,Kashida Y,Machida N,Mistumori K

更新日期：2005-02-28 00:00:00

abstract：:Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...

journal_title：Toxicology

authors： Bull RJ,Sanchez IM,Nelson MA,Larson JL,Lansing AJ

更新日期：1990-09-01 00:00:00

abstract：:The present study was examined whether or not 2-bromoethyamine, a semicarbazide-sensitive amine oxidase (SSAO, EC; 1.4.3.6) inhibitor, would increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical ((*)OH) generation in the rat striatum. Rats were anesthetized, and ...

journal_title：Toxicology

authors： Obata T

更新日期：2006-01-20 00:00:00

abstract：:T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in human nutrition. Several acute and chronic toxic effects were ...

journal_title：Toxicology

authors： Königs M,Mulac D,Schwerdt G,Gekle M,Humpf HU

更新日期：2009-04-28 00:00:00

abstract：:Choice behavior of rats in a radially symmetrical 6-arm maze, without food reward, was validated for assessing changes in learning and memory following treatment with 4 psychoactive agents. The test is designed for future use in routine toxicity studies with laboratory rodents. Each radial main arm of the maze leads t...

journal_title：Toxicology

authors： Fitzgerald RE,Berres M,Schaeppi U

更新日期：1988-05-01 00:00:00

abstract：:In an attempt to assess the effect of ethanol on cadmium accumulation, metallothionein (MT) synthesis, Cd-binding capacity and lipid peroxidation, rats were administered either Cd, ethanol or their combination for a period of 4 weeks. A significant increase in Cd accumulation was observed in all the organs of rats und...

journal_title：Toxicology

authors： Sharma G,Nath R,Gill KD

更新日期：1992-01-01 00:00:00

abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...

journal_title：Toxicology

authors： Hasegawa R,Murasaki G,St John MK,Zenser TV,Cohen SM

更新日期：1990-06-01 00:00:00

abstract：:Male Wistar rats were exposed to 200, 1000 or 2000 ppm of 1,1,2-trichloro-1,2,2-trifluoroethane vapor 5 days a week 6 h daily for 1 or 2 weeks. Proliferation and vacuolisation of the smooth endoplasmic reticulum (SER) of the liver was seen electron microscopically after 1 and 2 weeks in the rats exposed to 1000 and 20...

journal_title：Toxicology

authors： Vainio H,Nickels J,Heinonen T

更新日期：1980-01-01 00:00:00

abstract：:The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined. Proliferation of ductal structures was preceded by extensive damage to hepatocytes in the centrilobular region. Focal proliferation of ducts and fibrous tissue was present at 3 months and typical areas of cholangiofibrosis at 6 mont...

journal_title：Toxicology

authors： Evans JG,Appleby EC,Lake BG,Conning DM

更新日期：1989-04-01 00:00:00

abstract：:Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...

journal_title：Toxicology

authors： Kawamura Y,Hayashi H,Masumura K,Numazawa S,Nohmi T

更新日期：2014-10-03 00:00:00

abstract：:Isolated perfused rat kidneys were used to determine the contribution of filtration and tubular transport of cisplatin to its nephrotoxicity. Perfusion of kidneys with 0.5 mM cisplatin concomitantly reduced tubular reabsorption of electrolytes and glomerular filtration rate in a time-dependent manner. These renal func...

journal_title：Toxicology

authors： Miura K,Goldstein RS,Pasino DA,Hook JB

更新日期：1987-05-01 00:00:00

abstract：:Synthetic pyrethroids are one of the most frequently and widely used class of insecticides, primarily because they have a higher insect to mammalian toxicity ratio than organochlorines or organophosphates. The basic structure of pyrethroids can be characterized as an acid joined to an alcohol by an ester bond. Pyrethr...

journal_title：Toxicology

authors： Laffin B,Chavez M,Pine M

更新日期：2010-01-12 00:00:00

abstract：:The two major mammalian metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), namely 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin and 2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin, have been synthesized. The compounds were individually administered to immature male Wistar rats and their effects on body weight loss, ...

journal_title：Toxicology

authors： Mason G,Safe S

更新日期：1986-10-01 00:00:00

abstract：:Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...

journal_title：Toxicology

authors： Vervliet P,Den Plas JV,De Nys S,Duca RC,Boonen I,Elskens M,Van Landuyt KL,Covaci A

更新日期：2019-05-15 00:00:00

abstract：:We had previously demonstrated that 1 mM 2,4-D inhibited cell growth, nucleic acid synthesis and protein synthesis (at the ribosomal level) of Azospirillum brasilense. These alterations were prevented by the presence of polyamines in the culture medium. On the other hand, polyamines did not affect the 2,4-D uptake. In...

journal_title：Toxicology

authors： Mori G,Fabra A,Castro S,Rivarola V,Giordano W,Balegno H

更新日期：1995-04-12 00:00:00

abstract：:The consumption of diets rich in plant foods are associated with a reduced risk of cardiovascular diseases. This study was aimed to evaluate the role of S-allylcysteine (SAC) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (150 mg/kg) to Wistar rats showed a significant...

journal_title：Toxicology

authors： Padmanabhan M,Prince PS

更新日期：2006-07-05 00:00:00

abstract：:Organotellurides are important intermediates in organic synthesis and, consequently, the occupational exposure to them is a constant risk for laboratory workers. These compounds can elicit many neurotoxic events in the central nervous system (CNS) that are associated with several neurological symptoms. In contrast, or...

journal_title：Toxicology

authors： Funchal C,Moretto MB,Vivian L,Zeni G,Rocha JB,Pessoa-Pureur R

更新日期：2006-05-01 00:00:00

abstract：:Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

journal_title：Toxicology

authors： Miller CS

更新日期：1996-07-17 00:00:00

abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...

journal_title：Toxicology

authors： Ichihashi M,Ueda M,Budiyanto A,Bito T,Oka M,Fukunaga M,Tsuru K,Horikawa T

更新日期：2003-07-15 00:00:00

abstract：:Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method pr...

journal_title：Toxicology

authors： Barril JB,Vilanova E,Pellin MC

更新日期：1988-04-01 00:00:00

abstract：:Utah Valley has provided an interesting and unique opportunity to evaluate the health effects of respirable particulate air pollution (PM10). Residents of this valley are predominantly nonsmoking members of the Church of Jesus Christ of Latter-day Saints (Mormons). The area has moderately high average PM10 levels with...

journal_title：Toxicology

authors： Pope CA 3rd

更新日期：1996-07-17 00:00:00

abstract：:The effects of N-acetylcysteine (NAC), 2-mercaptopropionylglycine (MPG) and dithiothreitol (DTT) on the metabolism and toxicity of acetaminophen (APAP) were examined in isolated mouse hepatocytes maintained in primary culture on collagen-coated dishes. Both NAC and MPG increased the formation of the glutathione and su...

journal_title：Toxicology

authors： Harman AW,Self G

更新日期：1986-10-01 00:00:00

abstract：:It is well known that selenium is highly toxic to several species of mammals. Here we report the potential neurotoxicity of diselenides, as measured by the manifestation of seizures. The modulation of various neurotransmitter systems potentially involved in seizure episodes and death was also evaluated. The results of...

journal_title：Toxicology

authors： Nogueira CW,Meotti FC,Curte E,Pilissão C,Zeni G,Rocha JB

更新日期：2003-02-01 00:00:00

abstract：:In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...

journal_title：Toxicology

authors： Gottschall DW,Harder RR,Wiley RA,Hanzlik RP

更新日期：1984-06-01 00:00:00

abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...

journal_title：Toxicology

authors： Gorman D,Drewry A,Huang YL,Sames C

更新日期：2003-05-01 00:00:00