Abstract：
:Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method proposed. Proximo-distal distribution showed a significant difference from proximal (100 +/- 10%) to distal (69 +/- 9%) fragments, in accordance with reported data. The time course of in vivo regeneration after a single TOCP dose (200 mg/kg, post oral) showed some differences when compared with hen brain NTE. Sciatic nerve NTE showed a delay of 2-3 days before regeneration but then regenerated faster (74% activity at day 7) than brain NTE (50% activity at day 7). A slower rate of regeneration of distal than proximal segments has been suggested to explain higher sensitivity of distal segments [3], however in this work no significant differences were observed in the rate of regeneration when comparing proximal and distal fragments.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Barril JB,Vilanova E,Pellin MCdoi
10.1016/0300-483x(88)90181-3subject
Has Abstractpub_date
1988-04-01 00:00:00pages
107-14issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(88)90181-3journal_volume
49pub_type
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