Abstract:
:Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) caused concentration-dependent muscle contracture that was not reversed by washing. Muscle damage was seen histologically and confirmed by quantification of creatine kinase-MB (CK-MB) release. Heating and preincubation of venom with p-bromophenacyl bromide (a phospholipase A2 inhibitor) abolished the venom-induced contracture and muscle damage. In contrast, indomethacin, a non-selective inhibitor of cyclooxygenase, and verapamil, a voltage-gated Ca(2+) channel blocker, did not affect the responses to venom. Preincubation of venom with Bothrops or Bothrops/Crotalus antivenom or the addition of antivenom soon after venom attenuated the venom-induced changes in atrial function and tissue damage. These results indicate that B. jararacussu venom adversely affected rat atrial contractile activity and muscle organization through the action of venom PLA2; these venom-induced alterations were attenuated by antivenom.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Rodrigues MA,Dias L,Rennó AL,Sousa NC,Smaal A,da Silva DA,Hyslop Sdoi
10.1016/j.tox.2014.06.010subject
Has Abstractpub_date
2014-09-02 00:00:00pages
109-24eissn
0300-483Xissn
1879-3185pii
S0300-483X(14)00132-2journal_volume
323pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The effect of zinc (Zn) on the immunomodulatory properties of cadmium (Cd) was investigated in male Wistar rats. Animals were orally exposed to Cd and or Zn, by stomach tubing for 7 weeks. Response of splenocytes to phytohemagglutinin (PHA) and concanavalin A (Con A), was significantly increased by Zn. When exposed in...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90046-5
更新日期:1984-12-01 00:00:00
abstract::Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.10.002
更新日期:2017-12-01 00:00:00
abstract::Excretion and organ distribution of mercury and susceptibility to methylmercury (MeHg) toxicity were compared between strains and sexes after successive oral administration of MeHg chloride (5 mg/kg per day) using BALB/cA (C) and C57BL/6N (B6) mice. Every mouse died several days after initiation of toxic symptoms, and...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90079-0
更新日期:1988-09-01 00:00:00
abstract::In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00101-7
更新日期:1997-10-19 00:00:00
abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) is an agricultural fungicide which has been shown to induce acute tubular necrosis. The purpose of the present study was to determine if creatinine clearance was altered early in the development of NDPS nephrotoxicity. This study also examined the effect of autacoid modulation ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90007-n
更新日期:1991-01-01 00:00:00
abstract::Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic my...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.04.059
更新日期:2009-08-03 00:00:00
abstract::Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00060-x
更新日期:2003-05-03 00:00:00
abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90085-f
更新日期:1991-01-01 00:00:00
abstract::The effects of acute ethanol and acetaldehyde treatment on cell proliferation, cell adhesion capacity, neutral red incorporation into lysosomes, glutathione content, protein sulfhydryl compounds, lipid peroxidation, inner mitochondrial membrane integrity (MTT test), lactate dehydrogenase activity (LDH) and ultrastruct...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)03650-0
更新日期:1997-06-27 00:00:00
abstract::Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.12.009
更新日期:2007-03-07 00:00:00
abstract::Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90059-2
更新日期:1977-04-01 00:00:00
abstract::Immunotoxicology originated in the early 1970s, when scientists began investigating chemicals. During the 1970s and early 1980s, a few investigators determined that chemicals were immunotoxic, developed and/or refined immunoassays, and began to characterize immunotoxic responses. In the 1980s, many new investigators e...
journal_title:Toxicology
pub_type: 历史文章,杂志文章
doi:10.1016/s0300-483x(00)00434-0
更新日期:2001-03-07 00:00:00
abstract::Human liver microsomes, supersomes from baculovirus-transformed insect cells expressing different human CYP450 isoforms, and control and CYP3A4 cDNA-transfected V79 Chinese hamster cells were tested for their ability to metabolize territrem B (TRB) and territrem C (TRC). Two TRB metabolites, designated MB(2) and MB(4)...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.10.010
更新日期:2006-02-01 00:00:00
abstract::Quartz is a well-known occupational fibrogenic agent able to cause fibrosis and other severe pulmonary diseases such as silicosis and lung cancer. The silicotic pathology owes its severity to the structural and chemo-physical properties of the particles such as shape, size and abundance of surface radicals. In earlier...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.07.001
更新日期:2016-06-15 00:00:00
abstract::Both 4,4'-dichlorobiphenyl (4,4'-DCB) and 3-methylcholanthrene (3-MC) caused a substantial increase of phenacetin-induced hepatic glutathione (GSH) depletion, whereas phenobarbital (PB) had no effect, suggesting that 4,4'-DCB possesses cytochrome P-448 inducing activity. The O-deethylation of phenacetin by liver micro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90014-4
更新日期:1986-12-15 00:00:00
abstract::Tetrahydrocannabinol (THC), a psychoactive component of marijuana, is known to exert cytotoxicity in immune cells. In the present study, we examined the cytotoxicity of Δ⁸-THC in mouse macrophage J774-1 cells and a possible involvement of cannabinoid receptors and stress-responsive mitogen-activated protein kinases (M...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.10.007
更新日期:2013-12-15 00:00:00
abstract::Human exposure assessment is frequently noted as a weak link and bottleneck in the risk assessment process. Fortunately, the World Wide Web and Internet are providing access to numerous valuable sources of human exposure assessment-related information, along with opportunities for information exchange. Internet mailin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.025
更新日期:2004-05-20 00:00:00
abstract::To further investigate the immunotoxic effects of tri-n-propyltin chloride (TPTC), tri-n-butyltin chloride (TBTC) and triphenyltin chloride (TPhTC) several cytotoxicity tests with a series of trialkyltin chlorides and TPhTC were carried out, using isolated rat thymocytes as target cells. Thymocytes, cultured in a seru...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90160-5
更新日期:1986-04-01 00:00:00
abstract::Korea has a great diversity in resources of medicinal plants. The traditional herbal medicines and their preparations have been widely used in Korea as well as in China and Japan for thousands of years. One of the characteristics of Korean herbal medicine preparations is that all the herbal medicines are incorporated ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00487-0
更新日期:2002-12-27 00:00:00
abstract::Subchronic exposure to arsenic is associated with alteration of glucose homeostasis. Arsenic treatment (as sodium arsenite) of male Wistar rats (weighing 130-150 g) at a dose of 5.55 mg kg(-1) body weight (equivalent to 35% of LD(50)) (i.p.) per day for a period of 30 days produced hypoglycemia, with associated increa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.11.005
更新日期:2005-03-01 00:00:00
abstract::Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.05.013
更新日期:2004-10-15 00:00:00
abstract::Isolated perfused rat kidneys were used to determine the contribution of filtration and tubular transport of cisplatin to its nephrotoxicity. Perfusion of kidneys with 0.5 mM cisplatin concomitantly reduced tubular reabsorption of electrolytes and glomerular filtration rate in a time-dependent manner. These renal func...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90145-4
更新日期:1987-05-01 00:00:00
abstract::The aim of this study was to compare the roles of dihydropyridine calcium antagonists nifedipine, nitrendipine, amlodipine on doxorubicin (DXR)-induced nephrotoxicity in rats using biochemical, histopathological and immunohistochemical approaches. Male Sprague-Dawley rats were randomly divided into five experimental g...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.11.067
更新日期:2007-02-28 00:00:00
abstract::Intraperitoneal administration of Thimet (0.6 mg/kg) on alternate days for a period of 30 days produced various pathological and biochemical changes in the liver and testes of male gerbils. Histology of the liver showed necrosis, enlarged hepatocytes and fatty degeneration. Histological changes seen in the testes were...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90076-1
更新日期:1980-01-01 00:00:00
abstract::A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alky...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90032-5
更新日期:1984-07-01 00:00:00
abstract::Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. Diets containing 0, 1500, or 3000 ppm HC Blue 1 were fed to...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90130-3
更新日期:1989-06-01 00:00:00
abstract::Presently, many consumer products contain nano-sized materials (NMs) to improve material properties, product quality and ease of use. NMs in food additives and in cosmetic articles (e.g., tooth paste) may be taken up by the oral route. As adverse effects of environmental nanoparticles, like ultrafine particles, have b...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2011.11.004
更新日期:2012-01-27 00:00:00
abstract::Dietary exposure to vomitoxin (VT) results in hyperelevated serum IgA and IgA nephropathy in mice. To assess the possible role of cytokines in this IgA dysregulation, the effects of a single oral exposure in B6C3F1 male mice to 0, 5 or 25 mg/kg BW VT on production of IgA and cytokines in Peyer's patch (PP) and spleen ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00087-5
更新日期:1997-09-26 00:00:00
abstract::The toxicity to HeLa cells of 29 plasticizers was determined in the MIT-24 test system. The 7-day IC50 for HeLa cells varied from 260 to 1.5 g/l. Phthalates, adipates, sebacates, azelates and phosphates with long carbon chain alcohols were very non-toxic to the cells, probably due to insolubility in water of the compo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90002-6
更新日期:1982-01-01 00:00:00
abstract::Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment. Thiopronin contains an SH-group and is generally considered an antioxidant. The aim of the present study was to investigate the effects of thiopronin during liver injury and DNA damage induced by ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.08.006
更新日期:2009-10-29 00:00:00