Abstract:
:Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic myelogenous leukemia cell line K562 cells. Since steroid receptor coactivator-3 (SRC-3), overexpressed in many human malignancies including leukemia, is a central target for cancer therapy, we also explored the effects of GA on SRC-3 and SRC-3-regulated gene products in K562. GA treatment downregulated the expression of SRC-3 and then inhibited the activity of Akt kinase and its downstream targets p70 S6 kinase 1 (S6K1) and glycogen synthase kinase 3beta (GSK3beta) without changes in total protein levels of these three proteins, which thus influenced the expression of the apoptosis related gene Bcl-2 in K562 cells. These results suggest that GA might exhibit its strong antitumor effects via the interruption of SRC-3.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Li R,Chen Y,Zeng LL,Shu WX,Zhao F,Wen L,Liu Ydoi
10.1016/j.tox.2009.04.059subject
Has Abstractpub_date
2009-08-03 00:00:00pages
98-105issue
2eissn
0300-483Xissn
1879-3185pii
S0300-483X(09)00235-2journal_volume
262pub_type
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