The effects of the insecticide 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate on drug metabolism in the rat.

Abstract:

:The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) on hepatic, renal and small intestinal drug-metabolizing enzyme activities, hepatic reduced glutathione content and urinary excretion of thioethers were studied in the rat. A single i.p. dose of Penfenate (500 mg/kg) decreased the body weight of the animals in 1-3 days, increased hepatic protein content at 2 days and increased urinary thioether excretion 12-24 h after the treatment. In liver a single i.p. dose (500 mg/kg) enhanced cytochrome P-450 content 1.7-fold, ethoxycoumarin O-deethylase activity 2.5-fold, 2,5-diphenyloxazole hydroxylase activity 1.6-fold, epoxide hydrolase activity 2.5-fold, glutathione S-transferase activity 1.4-fold and UDPglucuronosyltransferase (4-methylumbelliferone) activity 2.3-fold in 3 days. No effects could be seen 2 weeks after the treatment. Five consecutive daily doses (500 mg/kg) enhanced the drug metabolizing enzyme activities and caused a 50% mortality. A dose of 100 mg/kg had only minor effects on hepatic drug metabolizing enzyme activities. Renal and intestinal enzyme activities were only slightly affected by the administration of Penfenate. These data indicate that quite large doses of Penfenate are needed to bring about any significant effects and these effects are restricted mainly to the liver. However, the ability of Penfenate to change drug metabolizing enzyme activities must be considered when evaluating the advantages and disadvantages of this insecticide as a substitute for DDT.

journal_name

Toxicology

journal_title

Toxicology

authors

Mäntylä E,Ahotupa M,Hietanen E,Vainio H

doi

10.1016/0300-483x(83)90028-8

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

327-36

issue

3-4

eissn

0300-483X

issn

1879-3185

pii

0300-483X(83)90028-8

journal_volume

27

pub_type

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