当前位置： SCI文献检索 > TOXICOLOGY期刊下所有文献 > Studies on brain lesions after administration of monosodium L-glutamate to mice. II. Absence of brain damage following administration of monosodium L-glutamate in the diet.

Studies on brain lesions after administration of monosodium L-glutamate to mice. II. Absence of brain damage following administration of monosodium L-glutamate in the diet.

Abstract：

:The effects of monosodium L-glutamate (MSG) on the brain of mice were examined by light-microscopy under the intended conditions of use of this material. Basal diet containing 5, 10 or 15% w/w MSG was fed to pregnant, lactating and weanling mice ad libitum, resulting in the ingestion of 14.0, 42.8 or 42.0 g/kg body wt. of MSG a day respectively. Mice at the same developmental stages were given the basal diet and 5% w/w MST in aqueous solution ad libitum, the maximum ingestion of MSG being 16.9, 31.4 and 26.8 g/kg body wt. a day respectively. Light-microscopy examination revealed no pathological changes in the hypothalamic arcuate nuclei (AN) of all treated mice, i.e., pregnant females and their fetuses, lactating females and their sucklings, and weanlin mice. Pregnant females and their fetuses, and weanling mice, injected subcutaneously with either 5.0 or 4.0 g/kg body wt. of MSG, showed "Glu-type lesions" in the hypothalamus.

journal_name

Toxicology

journal_title

Toxicology

authors

Takasaki Y

doi

10.1016/0300-483x(78)90014-8

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

307-18

issue

4

eissn

0300-483X

issn

1879-3185

pii

0300-483X(78)90014-8

journal_volume

9

pub_type

杂志文章

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