Abstract：
:This study evaluated a single intradermal injection model in the guinea pig with subsequent inhalation challenge and serological analysis as a method to predict the potential of chemicals to induce respiratory allergy. Four known respiratory allergens (trimellitic anhydride, diphenyl methane diisocyanate, phthalic anhydride and toluene diisocyanate (TDI)) were screened by two industrial research laboratories using this protocol. Dinitrochlorobenzene, a potent contact allergen, was included as a negative control material. In both laboratories, the respiratory allergens, but not the contact allergen, induced high titre antigen-specific antibodies in treated animals. The inhalation challenge results were similar in both laboratories but were less conclusive in that exposure to free TDI failed to induce pulmonary responses, probably because it fails to penetrate to the deep lung in sufficient concentration. Although the assay shows promise as a means of identifying chemical respiratory sensitisers, its use as a routine screen for the prediction of the ability of materials to induce respiratory allergy in man is probably questionable.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Blaikie L,Morrow T,Wilson AP,Hext P,Hartop PJ,Rattray NJ,Woodcock D,Botham PAdoi
10.1016/0300-483x(94)03007-osubject
Has Abstractpub_date
1995-01-19 00:00:00pages
37-50issue
1eissn
0300-483Xissn
1879-3185pii
0300483X9403007Ojournal_volume
96pub_type
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