Abstract:
:Microcystine-YR (20 ug/kg bodyweight) and 8 ug/kg bodyweight of nodularin were intraperitoneally injected to 90 female Swiss mice. After 15, 30, 60 min and 24 h the changes were observed in the activity of some glucosidases in the complete cell homogenate and in the lysosomal, microsomal and cytosol fraction. Significant differences were connected with the time after administration of poison and with the cellular fraction. Nodularin induces the activity of beta-D-glucuronidase, alpha-glucosidase, lysosomal esterase and N-acetyl-glucosaminidase and influenced on the labilization of endoplasmatic reticulum membranes. Microcystine-YR inhibited the biosynthesis of glucosidases and revealed a destructive effect on membranes of lysosomes and endoplasmatic reticulum.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Lankoff A,Kolataj Adoi
10.1016/s0300-483x(00)00173-6keywords:
subject
Has Abstractpub_date
2000-05-05 00:00:00pages
177-85issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300483X00001736journal_volume
146pub_type
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