Influence of microcystine-YR and nodularin on the activity of some glucosidases in mouse liver.

Abstract:

:Microcystine-YR (20 ug/kg bodyweight) and 8 ug/kg bodyweight of nodularin were intraperitoneally injected to 90 female Swiss mice. After 15, 30, 60 min and 24 h the changes were observed in the activity of some glucosidases in the complete cell homogenate and in the lysosomal, microsomal and cytosol fraction. Significant differences were connected with the time after administration of poison and with the cellular fraction. Nodularin induces the activity of beta-D-glucuronidase, alpha-glucosidase, lysosomal esterase and N-acetyl-glucosaminidase and influenced on the labilization of endoplasmatic reticulum membranes. Microcystine-YR inhibited the biosynthesis of glucosidases and revealed a destructive effect on membranes of lysosomes and endoplasmatic reticulum.

journal_name

Toxicology

journal_title

Toxicology

authors

Lankoff A,Kolataj A

doi

10.1016/s0300-483x(00)00173-6

keywords:

subject

Has Abstract

pub_date

2000-05-05 00:00:00

pages

177-85

issue

2-3

eissn

0300-483X

issn

1879-3185

pii

S0300483X00001736

journal_volume

146

pub_type

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