Abstract：
:Sodium fluoride (NaF) is widely used for the treatment of dental caries and dentin hypersensitivity. However, its pro-apoptotic effect on odontoblasts may lead to harmful side-effects. The purpose of this study was to evaluate the pro-apoptotic effects of NaF in odontoblasts and elucidate the possible underlying molecular mechanisms. NaF generated cytotoxic effects in odontoblast-lineage cell (OLC) in a dose- and time-dependent manner. Exposure of cells to 4mM NaF for 24h induced caspase-3 activation, ultrastructural alterations, and resulted in the translocation of Bax to the mitochondria and the release of cytochrome c from the mitochondrial inter-membrane space into the cytosol, indicating that fluoride-mediated apoptosis is mitochondria-dependent. Fluoride treatment also increased phosphorylation of JNK and ERK, but not p38, and apoptosis induced by fluoride was notably or partly suppressed by treatment with JNK or ERK inhibitors, respectively. Taken together, these findings suggest that NaF induces apoptosis in OLC odontoblasts through a JNK-dependent mitochondrial pathway.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Li P,Xue Y,Zhang W,Teng F,Sun Y,Qu T,Chen X,Cheng X,Song B,Luo W,Yu Qdoi
10.1016/j.tox.2013.03.016subject
Has Abstractpub_date
2013-06-07 00:00:00pages
138-45eissn
0300-483Xissn
1879-3185pii
S0300-483X(13)00078-4journal_volume
308pub_type
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