Abstract:
:Deltamethrin, a synthetic dibromo-pyrethroid insecticide, is extensively used in agriculture, forestry and in household products because of its high activity against a broad spectrum of insect pests (both adults and larvae), its low animal toxicity and its lack of persistence in the environment. Data on the genotoxicity and carcinogenicity of deltamethrin are rather controversial, depending on the genetic system or the assay used. The aim of this study was to further evaluate the potential genotoxic activity of deltamethrin. The in vitro genotoxicity of deltamethrin has been evaluated by assessing the ability of the insecticide to damage DNA (as evaluated using the single-cell microgel-electrophoresis or 'comet' assay) or induce sister-chromatid exchanges (SCE) and micronuclei (MN) in human peripheral blood leukocytes. All treatments were conducted with and without the presence of an external bioactivation source (+/- S9mix). The results indicate that deltamethrin, in the presence of metabolic activation (+ S9mix), is able to induce DNA damage (double- and single-strand breaks, alkali-labile sites and open excision repair sites) as revealed by the increasing tail moment values observed with increasing doses. The frequency of SCE and MN were not statistically increased in deltamethrin-treated cells as compared to controls, both with and without S9mix. However, lower deltamethrin doses were tested, as compared to 'comet' assay, because of cytotoxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Villarini M,Moretti M,Pasquini R,Scassellati-Sforzolini G,Fatigoni C,Marcarelli M,Monarca S,Rodríguez AVdoi
10.1016/s0300-483x(98)00097-3subject
Has Abstractpub_date
1998-09-15 00:00:00pages
129-39issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(98)00097-3journal_volume
130pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Multidrug resistance type 1 P-glycoproteins (P-gp) and multidrug resistance associated proteins (MRP) were studied in differentiated primary human lung cells in culture, in comparison with permanent human lung cell lines and primary alveolar type II cells from rat lung. AII cells exhibited low basal levels of mdr1b mR...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00458-9
更新日期:2001-10-05 00:00:00
abstract::Toxicity and other relevant data for 30 organophosphate pesticides were evaluated to suggest inhalation occupational exposure limits (OELs), and to support development of a risk assessment strategy for organophosphates in general. Specifically, the value of relative potency analysis and the predictability of inhalatio...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00219-5
更新日期:2000-09-07 00:00:00
abstract::4-Amino-2,6-dichlorophenol (ADCP) is a potent acute nephrotoxicant in vivo inducing prominent renal corticomedullary necrosis. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. The purpose of this study was to examine the ability of antioxidants...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.12.014
更新日期:2008-03-12 00:00:00
abstract::The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90119-3
更新日期:1987-07-01 00:00:00
abstract::Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.012
更新日期:2019-04-15 00:00:00
abstract::Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90103-8
更新日期:1983-09-01 00:00:00
abstract::Benzo(a)pyrene (B(a)P) is an environment carcinogen that can enhance cell proliferation by disturbing the signal transduction pathways in cell cycle regulation. The p53 tumor suppressor as a cell cycle check-point determinant plays a critical role in cell proliferation. However, the mechanism of p53 that accounts for ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.018
更新日期:2009-02-04 00:00:00
abstract::Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00144-4
更新日期:2000-01-17 00:00:00
abstract::Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90120-4
更新日期:1986-02-01 00:00:00
abstract::Induction of oxidative stress by 2,4-dichlorophenoxyacetic acid (2,4-D) both as a pure compound and in commercial formulation was investigated during early pregnancy in mice. Pregnant animals were exposed to increasing doses of the herbicide (0.01, 0.1 and 100mg/kg/d) during gestation days 0-9, after which animals wer...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.002
更新日期:2007-07-31 00:00:00
abstract::Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00542-5
更新日期:2003-02-01 00:00:00
abstract::The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions. In this study, stress-inducible HSP 70 was assessed by slot-blotting in rat lungs (N=10 per...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03250-j
更新日期:1996-02-22 00:00:00
abstract::In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90106-9
更新日期:1984-06-01 00:00:00
abstract::The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interleukin-2 (IL-2) production of lymph node cells. At the mRNA level, no c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.09.003
更新日期:2005-01-15 00:00:00
abstract::Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00403-6
更新日期:2001-08-13 00:00:00
abstract::The effects of triethyl lead chloride (TEL) on the expression of two detoxication enzyme families, glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase (QR) were determined in rat liver and kidney. Fischer 344 rats were given one intraperitoneal (i.p.) injection of TEL. GST activity, GST isoenzyme leve...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03555-x
更新日期:1997-02-14 00:00:00
abstract::It is well-known that organotellurium compounds can have antioxidant activity in vitro, but in vivo these compounds can be potentially toxic to rodents. Here we investigated the potential in vitro and ex vivo toxicity of a new beta-organochalcogenyl vinylphosphonate, the diethyl 2-phenyl-2 tellurophenyl vinylphosphona...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.027
更新日期:2006-07-05 00:00:00
abstract::Ochratoxin A (OCT A) has the potential to cause myelotoxicity in addition to the well-known toxic effects on the liver and kidney. Whereas in previous studies the bone marrow parameters were examined shortly after injection, experiments reported here were designed to determine whether mice would recover from the myelo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90236-3
更新日期:1988-12-16 00:00:00
abstract:BACKGROUND:Endotoxin/LPS is ubiquitous in our environment. The question whether lipopolysaccharide (LPS) is beneficial or disease-promoting in relation to asthma and allergy has been raised in several recent studies. Some have reported a positive correlation between the level of LPS in house dust and the symptoms of as...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00078-7
更新日期:2003-06-30 00:00:00
abstract::Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.09.010
更新日期:2019-01-01 00:00:00
abstract::Flucloxacillin is a semi-synthetic penicillin widely used in the prophylaxis and treatment of staphylococcal infections. Severe liver reactions, characterised by delayed cholestatic hepatitis and a prolonged course of recovery, are associated with flucloxacillin therapy. Clinical findings are suggestive of an immune m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.07.015
更新日期:2005-12-01 00:00:00
abstract::The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.06.008
更新日期:2005-11-05 00:00:00
abstract::Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.05.014
更新日期:2013-09-06 00:00:00
abstract::To evaluate hydroperoxide generation as a potential mechanism of cyanide neurotoxicity, mice were treated with KCN (7 mg/kg, subcutaneously (s.c.)) and the level of lipid peroxidation (expressed as conjugated dienes) was measured later in various organs. Brain showed elevated conjugated diene levels after cyanide but ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90221-6
更新日期:1994-04-18 00:00:00
abstract::Because it had been suggested that alpha-tocopherol might protect protein thiols (PSH) from oxidation, we were interested in determining if alpha-tocopherol could prevent or mitigate nitrofurantoin-induced changes in the glutathione (GSH) or PSH status of the liver. Isolated rat livers were perfused in the single pass...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90140-v
更新日期:1991-04-08 00:00:00
abstract::Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects of ACO and other related compounds on ion currents in Jurkat T-lymphocytes were investigated in this study. ACO suppres...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.07.003
更新日期:2011-10-28 00:00:00
abstract::The agricultural fungicide, N-(3,5-dichlorophenyl)succinimide (NDPS) induces acute polyuric renal failure which is attenuated by pretreatment with the glutathione depletors, diethyl maleate or buthionine sulfoximine (BSO). In the present study, the temporal aspects of BSO attenuation of NDPS nephrotoxicity were invest...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03581-0
更新日期:1997-02-28 00:00:00
abstract::Microcystins are cyclic heptapeptide toxins produced by certain strains of Microcystis aeruginosa and microcystin-LR (MC-LR) is the most toxic among the 70 variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we investigated the microcystin-LR induced ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.12.007
更新日期:2006-03-15 00:00:00
abstract::The importance of dietary factors for prostate carcinogenesis has been proven by epidemiological studies of immigrants from Asia into the USA. Intake of foodstuffs rich in fat, including meat, is suggested to be a risk factor. Experimentally, while some studies demonstrated high fat intake to promote rat prostate carc...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00260-3
更新日期:2002-12-27 00:00:00
abstract::Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.06.010
更新日期:2014-09-02 00:00:00