Hippocampal and striated skeletal muscle changes in fatty acid composition induced by ethanol in alcohol-preferring rats.

abstract：:We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...

journal_title：Toxicology

authors： Takeda S,Yamaori S,Motoya E,Matsunaga T,Kimura T,Yamamoto I,Watanabe K

更新日期：2008-03-12 00:00:00

abstract：:The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...

journal_title：Toxicology

authors： Johnson MK,Vilanova E,Read DJ

更新日期：1989-01-01 00:00:00

abstract：:Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pathway was involved in BPA-induced Sertoli cells injury via t...

journal_title：Toxicology

authors： Qian W,Zhu J,Mao C,Liu J,Wang Y,Wang Q,Liu Y,Gao R,Xiao H,Wang J

更新日期：2014-10-03 00:00:00

abstract：:Previous reports from this laboratory have established the propensity of chlordecone to potentiate the hepatotoxicity and lethality in male and female rats. The present study was designed to investigate the hepatotoxicity of CCl4 in chlordecone (CD) pretreated, ovariectomized rats. Ten days after bilateral ovariectomy...

journal_title：Toxicology

authors： Agarwal AK,Mehendale HM

更新日期：1984-02-01 00:00:00

abstract：:p-Dichlorobenzene (p-DCB) is widely used as a moth repellent and a space deodorant. In mice pretreated with DL-buthionine sulfoximine (BSO; 2 mmol/kg or higher doses, i.p.), an inhibitor of glutathione (GSH) synthesis, administration of p-DCB (100-400 mg/kg, p.o.) resulted in dose-dependent hepatotoxicity as judged by...

journal_title：Toxicology

authors： Mizutani T,Nakahori Y,Yamamoto K

更新日期：1994-11-01 00:00:00

abstract：:Metabonomics involves the application of advanced analytical tools to profile the diverse metabolic complement of a given biofluid or tissue. Subsequent statistical modelling of the complex multivariate spectral profiles enables discrimination between phenotypes of interest and identifies panels of discriminatory meta...

journal_title：Toxicology

authors： Coen M

更新日期：2010-12-30 00:00:00

abstract：:Rats were exposed to 1.5 +/- 0.1 mg ozone/m3 for 4 days and the activities of glucose-6-P dehydrogenase (G6PDH), glutathione reductase (GR) and glutathione peroxidase (GSHPx) were measured in the cytosolic fraction of lungs from exposed and control rats. Enzyme activities were also measured in isolated alveolar macrop...

journal_title：Toxicology

authors： Rietjens IM,Van Bree L,Marra M,Poelen MC,Rombout PJ,Alink GM

更新日期：1985-12-01 00:00:00

abstract：:Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that include burning sensation, irritation and epit...

journal_title：Toxicology

authors： Nagai N,Ito Y,Okamoto N,Shimomura Y

更新日期：2014-05-07 00:00:00

abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...

journal_title：Toxicology

authors： Farris GM,Newman LS,Frome EL,Shou Y,Barker E,Habbersett RC,Maier L,Smith HN,Marrone BL

更新日期：2000-02-21 00:00:00

abstract：:One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to sheep red blood cells (SRBCs) in mice. Immunosuppression occurs in concert with hepatomegaly and associated induction of several hepatic cytochrome P450 enz...

journal_title：Toxicology

authors： Smialowicz RJ,Burgin DE,Williams WC,Diliberto JJ,Setzer RW,Birnbaum LS

更新日期：2004-04-01 00:00:00

abstract：:The development of poisons information centers has in general complied with the actual needs and conditions in the society, and a pragmatic approach and limited funds have been characteristic for these units. To operate in a satisfying way a poisons information center is dependent on two cornerstones-a well educated a...

journal_title：Toxicology

authors： Persson H,Tempowski J

更新日期：2004-05-20 00:00:00

abstract：:Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...

journal_title：Toxicology

authors： Bourian M,Gullstén H,Legrum W

更新日期：2000-04-03 00:00:00

abstract：:The breast cancer resistance protein (Bcrp) is an efflux transporter that participates in the biliary and renal excretion of drugs and environmental chemicals. Recent evidence suggests that pharmacological activation of the peroxisome proliferator activated receptor alpha (PPARα) can up-regulate the hepatic expression...

journal_title：Toxicology

authors： Eldasher LM,Wen X,Little MS,Bircsak KM,Yacovino LL,Aleksunes LM

更新日期：2013-04-05 00:00:00

abstract：:Aromatase enzyme plays a central role in steroidogenesis by converting androgens to estrogens and has been proposed as an important molecular target for many environmental endocrine disrupters chemicals. In this study, we have screened 30 selected pesticides with known, unknown or supposed effects on aromatase activit...

journal_title：Toxicology

authors： Laville N,Balaguer P,Brion F,Hinfray N,Casellas C,Porcher JM,Aït-Aïssa S

更新日期：2006-11-10 00:00:00

abstract：:Hydroquinone (HQ) is naturally found in the diet, drugs, as an environmental contaminant and endogenously generated after benzene exposure. Considering that HQ alters the immune system and its several source of exposures in the environment, we hypothesized that prolonged exposure of HQ could affect the course of an im...

journal_title：Toxicology

authors： Macedo SM,Vaz SC,Lourenço EL,de Sousa Mda G,Ligeiro-Oliveira AP,Ferreira JM Jr,Almeida SR,de Lima WT,Farsky SH

更新日期：2007-11-20 00:00:00

abstract：OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....

journal_title：Toxicology

authors： Tian L,Yan J,Li K,Zhang W,Lin B,Lai W,Bian L,Liu H,Xi Z,Liu X

更新日期：2020-12-28 00:00:00

abstract：:Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...

journal_title：Toxicology

authors： Travacio M,María Polo J,Llesuy S

更新日期：2000-09-07 00:00:00

abstract：:Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting c...

journal_title：Toxicology

authors： Wang Q,Shen JY,Zhang R,Hong JW,Li Z,Ding Z,Wang HX,Zhang JP,Zhang MR,Xu LC

更新日期：2020-05-30 00:00:00

abstract：:Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fragments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the ...

journal_title：Toxicology

authors： Advenier E,Mouajjah S,Bazin-Redureau M,Launay JM,Scherrmann JM

更新日期：1998-04-03 00:00:00

abstract：:In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...

journal_title：Toxicology

authors： Gergely A,Soós K,Erdélyi L,Cieleszky V

更新日期：1977-06-01 00:00:00

abstract：:The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing metabolic activation by a variety of cytochrome P450 isoforms to produce ...

journal_title：Toxicology

authors： Ramos S,Sultatos L

更新日期：1998-11-16 00:00:00

abstract：:The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions. In this study, stress-inducible HSP 70 was assessed by slot-blotting in rat lungs (N=10 per...

journal_title：Toxicology

authors： Wong CG,Bonakdar M,Mautz WJ,Kleinman MT

更新日期：1996-02-22 00:00:00

abstract：:The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic r...

journal_title：Toxicology

authors： Friedman SL

更新日期：2008-12-30 00:00:00

abstract：:Phensuximide (PSX) is an antiepileptic agent which has been shown to induce hemorrhagic cystitis and mild nephrotoxicity following repeated administration in man or rats or when acutely administered to phenobarbital-pretreated rats. The purpose of this study was to explore the role of para-hydroxylation of the phenyl ...

journal_title：Toxicology

authors： Rankin GO,Beers KW,Nicoll DW,Anestis DK,Shih HC,Brown PI,Hubbard JL

更新日期：1992-08-01 00:00:00

abstract：:Lead-exposed mice were found to show a significantly increased frequency of acrosome-reacted spermatozoa. The number of spermatozoa bound to the zona pellucida of denuded mouse eggs was also significant increased, probably as a result of an acceleration of the processes involved in the capacitation of the spermatozoa ...

journal_title：Toxicology

authors： Johansson L

更新日期：1989-02-01 00:00:00

abstract：:The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...

journal_title：Toxicology

authors： Muruganandan S,Lal J,Gupta PK

更新日期：2005-11-05 00:00:00

abstract：:The widespread use of tributyltin (TBT) as biocides in antifouling paints and agricultural chemicals has led to environmental and marine pollution. Human exposure occurs mainly through TBT contaminated seafood and drinking water. It is a well known endocrine disruptor in mammals, but its molecular mechanism in testicu...

journal_title：Toxicology

authors： Mitra S,Srivastava A,Khandelwal S

更新日期：2013-12-06 00:00:00

abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...

journal_title：Toxicology

authors： Nogueira CW,Borges VC,Zeni G,Rocha JB

更新日期：2003-09-30 00:00:00

abstract：:Exposure of pregnant C3H/HeNCR mice to 42.5- or 85-ppm of arsenic as sodium arsenite in drinking water between days 8 and 18 of gestation markedly increases tumor incidence in their offspring. In the work reported here, distribution of inorganic arsenic and its metabolites, methyl arsenic and dimethyl arsenic, were de...

journal_title：Toxicology

authors： Devesa V,Adair BM,Liu J,Waalkes MP,Diwan BA,Styblo M,Thomas DJ

更新日期：2006-07-05 00:00:00

abstract：:Indoor suspended particulate matter (SPM) consists of many different types of particles, the vast majority of which are less than 2.5 microm in diameter. An important question is how these particles, being inhalable, contribute to asthma and respiratory symptoms. One possibility is that these particles have an adjuvan...

journal_title：Toxicology

authors： Ormstad H,Gaarder PI,Johansen BV,Løvik M

更新日期：1998-08-21 00:00:00