Abstract:
:After i.v. injection of 0.33 mg nicotine/kg the elimination of unchanged nicotine as well as nicotine-N-oxide, cotinine, nornicotine and norcotinine was determined in the urine of pigs dependent on time. In female pigs 16.3% and in male pigs 25.9% of the applied nicotine were recovered in form of the mentioned compounds within 31h. Nicotine elimination essentially stopped in the collecting period 3-8 h. The main decomposition products nicotine-N-oxide and cotinine were eliminated to a significant extent also 8-23 h after application.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Harke HP,Frahm Bdoi
10.1016/0300-483x(76)90013-5subject
Has Abstractpub_date
1976-06-01 00:00:00pages
125-8issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(76)90013-5journal_volume
6pub_type
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