Abstract:
:Epidemiological studies in humans and experimental work in rodents suggest that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental toxicant, is associated with incidence of heart disease. Although TCDD toxicity depends by and large on the aryl hydrocarbon receptor (AHR), the role of the cardiac AHR in TCDD induced cardiovascular disease is not well defined. To determine whether the Ahr gene mediates disruption of heart function by TCDD, we generated a cardiomyocyte-specific Ahr knockout mouse by crossing Ahr(fx/fx) mice with βMhc:cre/+ mice, in which expression of Cre recombinase is driven by the promoter of the βMhc (myosin heavy chain-beta) gene. Starting at three months of age, mice with cardiomyocyte-specific Ahr ablation were exposed to 1μg/kg/week of TCDD or control vehicle by oral gavage for an additional three months. Relative to unexposed controls, TCDD-exposure induced cardiomyocyte Ahr-independent changes in males but not females, including a significant increase in body weight, blood pressure, and cardiac hypertrophy and a decrease in cardiac ejection fraction. TCDD exposure also induced cardiomyocyte Ahr-dependent changes in fibrosis and calcium signaling gene expression in both males and females. TCDD exposure appears to cause sexually dimorphic effects on heart function and induce fibrosis and changes in calcium signaling in both males and females through activation of the cardiomyocyte-specific Ahr.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kurita H,Carreira VS,Fan Y,Jiang M,Naticchioni M,Koch S,Rubinstein J,Puga Adoi
10.1016/j.tox.2016.05.006subject
Has Abstractpub_date
2016-04-29 00:00:00pages
9-20eissn
0300-483Xissn
1879-3185pii
S0300-483X(16)30046-4journal_volume
355-356pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.08.008
更新日期:2006-10-29 00:00:00
abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00108-5
更新日期:1998-11-02 00:00:00
abstract::The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90100-4
更新日期:1987-08-01 00:00:00
abstract::Ghrelin stimulates growth hormone (GH) release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in several cell types but the precise underlying protective mechanisms in pancreatic beta cells are poorly understood. Therefore, we investigated which pathway was related...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.013
更新日期:2007-07-31 00:00:00
abstract::Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00254-7
更新日期:2000-09-07 00:00:00
abstract::Drug hypersensitivity reactions are a daily worry for the clinicians, in particular anaphylactic reactions. The tools allowing a definite diagnosis are few and poorly validated. They include a thorough clinical history, standardized skin tests, reliable biological tests, and sometimes drug provocation tests. These too...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2004.12.027
更新日期:2005-04-15 00:00:00
abstract::The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is an acute nephrotoxicant in rats. Our previous studies have strongly suggested that glucuronide conjugation of NDPS metabolites might be a bioactivation step mediating NDPS nephrotoxicity. In this study, effects of substrates and/or inhibitors of pr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00140-1
更新日期:1999-01-01 00:00:00
abstract::In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90052-x
更新日期:1977-06-01 00:00:00
abstract::Deltamethrin, a synthetic dibromo-pyrethroid insecticide, is extensively used in agriculture, forestry and in household products because of its high activity against a broad spectrum of insect pests (both adults and larvae), its low animal toxicity and its lack of persistence in the environment. Data on the genotoxici...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00097-3
更新日期:1998-09-15 00:00:00
abstract::The toxic oil syndrome (TOS), a multisystemic disease, that occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline. Due to the clinical course of the disease, immunopathological mechanisms have been suspected but a direct connection was never demonstrated. To analyse this poss...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90085-x
更新日期:1994-11-11 00:00:00
abstract::Chronic ethanol intake affects various organ systems of the body. The present study evaluated modifications of fatty acid concentrations both in brain and striated skeletal muscles of rats genetically selected for voluntary high ethanol intake. Three groups of rats were tracked for 10 weeks of access to ethanol only a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.02.023
更新日期:2004-07-01 00:00:00
abstract::The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2.0 mM) was incubated with a crude mitochondria fraction prepared from mouse brain at 37 degrees C for 60 min, the damage of mtDNA was observed in a concentration-dep...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00244-5
更新日期:2002-09-30 00:00:00
abstract::Since predictive differentiation of photoallergenic from phototoxic reactions, induced by low molecular weight compounds, represents a current problem, we tried to improve the differentiation between the two reactions by using a modified protocol of the local lymph node assay (LLNA). Briefly, groups of female BALB/c m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00156-x
更新日期:1998-02-06 00:00:00
abstract::The effects of D- and L-T3 were compared in male SK & F Wistar rats to define overall effects on the 'pituitary-thyroid-liver axis' at high doses. After in vivo administration of L-T3 (up to 1 mg/kg orally, or up to 0.1 mg/kg subcutaneously) serum TSH and T4 were decreased in a dose-related manner. Similarly, followin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90108-4
更新日期:1988-03-01 00:00:00
abstract::Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00542-5
更新日期:2003-02-01 00:00:00
abstract::The cytotoxicity of CdCl2 and 2 isoforms of hepatic cadmium-metallothionein (CdMT I and II), was investigated using primary cultures of rat hepatocytes. The cell cultures were exposed to cadmium as CdCl2 or as either isoform of CdMT for a 20-h period at concentrations ranging from 50 to 500 ng Cd X ml-1. Cytotoxicity ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90034-5
更新日期:1987-06-01 00:00:00
abstract::As vaccines are undoubtedly classified as pharmaceuticals, they have to be submitted to strict non-clinical safety evaluation. The context of their prophylactic use requires that every effort is made to ensure their safe use. Their safety evaluation is complex as they act through a multistage mechanism in which the va...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00055-0
更新日期:2002-05-15 00:00:00
abstract::A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00151-6
更新日期:1999-02-15 00:00:00
abstract::In rats, 3 days treatment with paracetamol (1 oral dose of 1 g/kg daily) produced a complete protection against the hepatotoxic actions of a further dose of paracetamol as documented by determination of serum enzyme activities (glutamic-oxaloacetic transaminase, (GOT), glutamic-pyruvic transaminase (GPT), sorbitol deh...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(79)90038-6
更新日期:1979-02-01 00:00:00
abstract::A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90074-3
更新日期:1993-06-04 00:00:00
abstract::Arsenic is an endocrine disruptor that promotes breast cancer (BCa) development. Estrogen synthesis, through aromatase activation, is essential for BCa promotion and progression through activating the G-coupled estrogen receptor 1 (GPER1), regulating rapid nongenomic effects involved in cell proliferation and migratio...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152440
更新日期:2020-05-15 00:00:00
abstract::Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP) and 3,5,6-trichloro-2-pyridinol (TCPy) are products of both in vivo metabolism and environmental degradation of CPF and are routinely measured in urine as biomarkers of ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.022
更新日期:2010-01-31 00:00:00
abstract::Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell's membrane. This review deals with the steps involved in pore-f...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(94)90156-2
更新日期:1994-02-28 00:00:00
abstract::L-695,256 is a novel 2-fluorenonyl carbapenem antibiotic with significant antimicrobial activity against strains of methicillin-resistant Staphylococci. This prototype compound was administered intravenously to rhesus monkeys (Macaca mulatta) at does of 50 or 200 mg/kg/day for 2 weeks to assess toxicity and found to i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03305-7
更新日期:1996-04-30 00:00:00
abstract::Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the p...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.009
更新日期:2009-01-31 00:00:00
abstract::Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2004.11.027
更新日期:2005-03-15 00:00:00
abstract::Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00083-9
更新日期:1999-10-29 00:00:00
abstract::The effects of xenobiotic drugs and toxic compounds depend largely on their kinetic properties, which can be influenced by transmembrane drug transporters like MDR1/P-glycoprotein and the drug-conjugate transporters multidrug resistance protein (MRP) 1 and 2. As the dog is a preferential species used in the pharmacolo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00354-1
更新日期:2001-01-02 00:00:00
abstract::Mitochondrial fission, fusion, and mitophagy are interlinked processes that regulate mitochondrial shape, number, and size, as well as metabolic activity and stress response. The fundamental importance of these processes is evident in the fact that mutations in fission (DRP1), fusion (MFN2, OPA1), and mitophagy (PINK1...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.05.018
更新日期:2017-07-15 00:00:00
abstract::The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.08.010
更新日期:2014-11-05 00:00:00