Abstract:
:The neurotoxic effect on the central and peripheral nervous system of dichlorvos (DDVP) was investigated by a computer system in acute and subchronic experiments in CFY male rats. The administered peroral doses were given by gavage; the acute group was given a single 88 mg/kg dose and the 2 subchronic groups were given 1.6 mg/kg or 0.8 mg/kg daily for a period of 6 weeks. Significant changes of the function of CNS - increase of EEG mean frequency, decrease of EEG mean amplitude, that of activity of EEG bands (power density) - and peripheral nervous system - decrease of conduction velocity, increase of relative and absolute refractory periods - were found after treatment with both the single large and repeated small doses of dichlorvos. There were no correlations between the functional disturbances of the central and peripheral nervous systems and the inhibition of the cholinesterase activity in various organs and the blood.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Dési I,Nagymajtényi Ldoi
10.1016/0300-483x(88)90186-2subject
Has Abstractpub_date
1988-04-01 00:00:00pages
141-8issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(88)90186-2journal_volume
49pub_type
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