Abstract：
:Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Ansari GA,Kaphalia BS,Boor PJdoi
10.1016/0300-483x(87)90137-5subject
Has Abstractpub_date
1987-10-12 00:00:00pages
57-63issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(87)90137-5journal_volume
46pub_type
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