Abstract:
:A number of clinical reports and experimental studies have shown that autoimmune responses and/or autoimmune diseases are induced in humans and laboratory animals by chronic exposure to various chemicals. The present review is focused on the most frequent groups of chemically induced human disorders. Results obtained from studies of the available counterparts of these diseases, i.e. those models obtained from the exposure of laboratory animals to various chemicals are analyzed. Although significant progress has been achieved to the realization that environmental agents may cause profound changes in our immune system and result in autoimmune disease, epidemiological, clinical and experimental work is still needed to acquire a better understanding of the mechanisms involved.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Bigazzi PEdoi
10.1016/s0300-483x(96)03591-3subject
Has Abstractpub_date
1997-04-11 00:00:00pages
1-21issue
1eissn
0300-483Xissn
1879-3185pii
S0300483X96035913journal_volume
119pub_type
杂志文章,评审相关文献
TOXICOLOGY文献大全abstract::We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.007
更新日期:2006-05-01 00:00:00
abstract::Our previous study revealed that exposure to 0.4 ppm ozone (O(3)) enhanced nasal allergy-like reactions in guinea pigs. In the present study, we investigated the concentration-dependency of the effects of exposure to O(3) on the aggravation of nasal allergy-like reactions induced by repeated nasal administration of an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.008
更新日期:2004-06-01 00:00:00
abstract::The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00129-x
更新日期:2003-08-01 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) have the potential to interfere with the hormonal system and may negatively influence human health. Microarray analysis was used in this study to investigate differential gene expression in human peripheral blood cells (PBMCs) after in vitro exposure to EDCs. PBMCs, isolated from ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.10.019
更新日期:2013-01-07 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) and N-nitrosamines (NNA) are mainly activated by cytochrome P450s, and their associated enzyme activities such as aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH), N-nitrosdimethylamine N-demethylase I (NDMA-dI), NADPH-cytochrome C reductase, and detoxified by glutathione S-t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00048-3
更新日期:2002-05-24 00:00:00
abstract::The attempts to use nitroxide free radicals and nitrone spin traps topically in skin requires analysis of their potential cutaneous adverse effects. The objective of this study was to investigate the skin irritation and sensitizing potential of nitroxides and nitrones in the guinea pig. The following unsubstituted nit...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00183-2
更新日期:1998-02-20 00:00:00
abstract::To evaluate hydroperoxide generation as a potential mechanism of cyanide neurotoxicity, mice were treated with KCN (7 mg/kg, subcutaneously (s.c.)) and the level of lipid peroxidation (expressed as conjugated dienes) was measured later in various organs. Brain showed elevated conjugated diene levels after cyanide but ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90221-6
更新日期:1994-04-18 00:00:00
abstract::The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tried to alleviate the...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.10.015
更新日期:2012-01-27 00:00:00
abstract::The effect of 6 weekly injections of ochratoxin A (5 mg/kg) and citrinin (20 mg/kg) on the following hematological indices of mice was studied: erythrocyte sedimentation rate, hematocrit percentage, mean corpuscular values, red cell indices, platelet count, total count of bone marrow cells, differential count of bone ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90056-2
更新日期:1983-01-01 00:00:00
abstract::Field observations of endocrine disruption (ED) in fish and other aquatic species have contributed to a global effort to establish test methods for detecting ED effects in wildlife species. For ecological risk assessment, validated tests are needed for Amphibia, fish and aquatic invertebrates, supported by a tiered ap...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00471-7
更新日期:2002-12-27 00:00:00
abstract::It has been widely accepted that microglia, which are the innate immune cells in the brain, upon activation can cause neuronal damage. In the present study, we investigated the role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in regulating microglial nitric oxide production and its role in causing neuronal damage. T...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.08.008
更新日期:2013-10-04 00:00:00
abstract::The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Oximes, such as K027 and HLö-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. To investiga...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.09.002
更新日期:2009-11-30 00:00:00
abstract::Lead-exposed mice were found to show a significantly increased frequency of acrosome-reacted spermatozoa. The number of spermatozoa bound to the zona pellucida of denuded mouse eggs was also significant increased, probably as a result of an acceleration of the processes involved in the capacitation of the spermatozoa ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90041-3
更新日期:1989-02-01 00:00:00
abstract::The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2021.152684
更新日期:2021-01-25 00:00:00
abstract::Chlorination of drinking water containing organic materials is known to generate toxic by-products. We suggested that such compounds may also be produced by interactions between chlorine and bacteria present in water. To confirm this hypothesis, a method based on RNA synthesis inhibition of HeLa S3 human cells in the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00317-6
更新日期:2000-11-16 00:00:00
abstract::It is well known that selenium is highly toxic to several species of mammals. Here we report the potential neurotoxicity of diselenides, as measured by the manifestation of seizures. The modulation of various neurotransmitter systems potentially involved in seizure episodes and death was also evaluated. The results of...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00423-7
更新日期:2003-02-01 00:00:00
abstract::In this report the neurotoxicity of aspartame and its constituent amino acids aspartic acid and phenylalanine is reviewed. The adverse reactions ascribed to the consumption of aspartame-containing products, as reported in the U.S.A., are discussed and placed in perspective with the results of recent behavioural studie...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(88)90117-5
更新日期:1988-06-01 00:00:00
abstract::Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(95)03230-d
更新日期:1995-12-28 00:00:00
abstract::In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two di...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00373-6
更新日期:2002-09-30 00:00:00
abstract::Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.05.013
更新日期:2004-10-15 00:00:00
abstract::Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects of ACO and other related compounds on ion currents in Jurkat T-lymphocytes were investigated in this study. ACO suppres...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.07.003
更新日期:2011-10-28 00:00:00
abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152564
更新日期:2020-11-01 00:00:00
abstract::Several types of pesticides, such as organophosphates, phenoxyacetic acid, and carbamate have a high risk of affecting human health, causing allergic rhinitis and bronchial asthma-like diseases. We used our long-term sensitization method and a local lymph node assay to examine the allergic reactions caused by several ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.05.014
更新日期:2009-07-10 00:00:00
abstract::Microcystins are cyclic heptapeptide toxins produced by certain strains of Microcystis aeruginosa and microcystin-LR (MC-LR) is the most toxic among the 70 variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we investigated the microcystin-LR induced ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.12.007
更新日期:2006-03-15 00:00:00
abstract::Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2010.08.007
更新日期:2010-12-30 00:00:00
abstract::Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.05.012
更新日期:2009-07-28 00:00:00
abstract::Myopathy is among the well documented and the most disturbing adverse effects of statins. The underlying mechanism is still unknown. Mitochondrial dysfunction related to coenzyme Q10 decline is one of the proposed theories. The present study aimed to investigate the mechanism of atorvastatin-induced myopathy in rats. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.015
更新日期:2016-06-01 00:00:00
abstract::Subcutaneous administration of methyl isocyanate (MIC) in 0.5 LD50 and 1 LD50 doses in female rabbits resulted in significant changes in physiological, clinico-chemical and histological parameters. There was a fall in arterial blood pressure and cardioacceleration in both the 0.5 LD50 and 1 LD50 groups, while the resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90152-7
更新日期:1988-10-01 00:00:00
abstract::Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.011
更新日期:2019-05-15 00:00:00
abstract::Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.07.010
更新日期:2010-10-09 00:00:00