Autoimmunity caused by xenobiotics.

Abstract:

:A number of clinical reports and experimental studies have shown that autoimmune responses and/or autoimmune diseases are induced in humans and laboratory animals by chronic exposure to various chemicals. The present review is focused on the most frequent groups of chemically induced human disorders. Results obtained from studies of the available counterparts of these diseases, i.e. those models obtained from the exposure of laboratory animals to various chemicals are analyzed. Although significant progress has been achieved to the realization that environmental agents may cause profound changes in our immune system and result in autoimmune disease, epidemiological, clinical and experimental work is still needed to acquire a better understanding of the mechanisms involved.

journal_name

Toxicology

journal_title

Toxicology

authors

Bigazzi PE

doi

10.1016/s0300-483x(96)03591-3

subject

Has Abstract

pub_date

1997-04-11 00:00:00

pages

1-21

issue

1

eissn

0300-483X

issn

1879-3185

pii

S0300483X96035913

journal_volume

119

pub_type

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