Investigations in bitro and in vivo, of the effects of disulfiram (Antabuse) on human lymphocyte chromosomes.

Abstract:

:Pilinskaya showed that the fungicide ziram induced chrocosome aberrations in the lymphocytes of exposed industrial workers and also in lymphocyte cultures treated in vitro. Ziram is chemically similar to the drug Antabuse (disulfirm) which is used in the treatment of alcoholics. To establish whether disulfirm can also cause chromosome aberrations, we have examined the chrocosomes of lymphocytes from treated and untreated alcoholics and normal controls, and also the chromosomes of lymphocytes treated in vitro. Our results show that disulfirm is 800 times less toxic than ziram and suggest that it is at least 10 000 times less active as an inducer of chromosome aberrations. We found no significant increase in aberrations in vitro or in vivo with disulfiram and conclude taht if it is an inducer of aberrations in lymphoctes then they must be induced with a very low frequency indeed.

journal_name

Toxicology

journal_title

Toxicology

authors

Lilly LJ

doi

10.1016/0300-483x(75)90055-4

keywords:

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

331-40

issue

3

eissn

0300-483X

issn

1879-3185

pii

0300-483X(75)90048-7

journal_volume

4

pub_type

杂志文章
  • Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse.

    abstract::The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(88)90133-3

    authors: Jonker D,Lee VS,Hargreaves RJ,Lake BG

    更新日期:1988-11-30 00:00:00

  • Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.

    abstract::Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactate dehydrogenase (LDH) leakage. Cellular glutathione (GSH) was depleted by adding buthionine sulfoximine (BSO) to the culture ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(96)03352-5

    authors: Jurima-Romet M,Abbott FS,Tang W,Huang HS,Whitehouse LW

    更新日期:1996-08-01 00:00:00

  • Psychophysiologic effects of early lead exposure.

    abstract::In several separate experiments neonatal rats were intubated daily with 9, 27 or 81 mg lead acetate/kg of body weight throughout their 3-week postnatal period of development. Based on average body weights, the total daily lead intake was 0.156, 0.454 or 1.384 mg lead per animal, respectively (in addition to normal lea...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(75)90115-8

    authors: Sobotka TJ,Brodie RE,Cook MP

    更新日期:1975-11-01 00:00:00

  • The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel.

    abstract::Aerolysin is a cytolytic toxin which forms channels in the plasma membranes of eucaryotic cells. The protein is secreted by Aeromonas hydrophila as an inactive protoxin. Its stability and water solubility are conferred by its ability to dimerize. Maturation of the protein occurs through proteolytic removal of a C-term...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/0300-483x(94)90152-x

    authors: van der Goot FG,Pattus F,Parker M,Buckley JT

    更新日期:1994-02-28 00:00:00

  • Interaction of air pollutants and pulmonary allergic responses in experimental animals.

    abstract::Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/0300-483x(95)03230-d

    authors: Gilmour MI

    更新日期:1995-12-28 00:00:00

  • Formaldehyde induces apoptosis through decreased Prx 2 via p38 MAPK in lung epithelial cells.

    abstract::Formaldehyde (FA) is an important substance that induces sick house syndrome and diseases, such as asthma and allergies. Oxidative stress is involved in the development of respiratory disease, and diverse antioxidants may protect respiratory tract cells from apoptosis. Peroxiredoxin is a pivotal endogenous antioxidant...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2010.03.011

    authors: Lim SK,Kim JC,Moon CJ,Kim GY,Han HJ,Park SH

    更新日期:2010-05-27 00:00:00

  • Role of antioxidants in paraquat toxicity.

    abstract::Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-483x(02)00382-7

    authors: Suntres ZE

    更新日期:2002-10-30 00:00:00

  • Oxidative stress and cytotoxicity of 4-(2-thienyl)butyric acid in isolated rat renal proximal tubular and distal tubular cells.

    abstract::Relative cytotoxicity and mechanism of action of thiophenes were investigated in suspensions of freshly isolated renal proximal tubular (PT) and distal tubular (DT) cells using 4-(2-thienyl)butyric acid (TByA) as a model compound. TByA produced significantly greater time- and concentration-dependent cytotoxicity, as a...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(95)03137-5

    authors: Lash LH,Tokarz JJ

    更新日期:1995-12-10 00:00:00

  • Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression.

    abstract::In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(01)00570-4

    authors: Kauffmann HM,Pfannschmidt S,Zöller H,Benz A,Vorderstemann B,Webster JI,Schrenk D

    更新日期:2002-02-28 00:00:00

  • Dose related effects of ifosfamide on enterocyte apoptosis in different sites of the rabbit intestine.

    abstract:OBJECTIVE:We investigated the potential dose related apoptotic effect of subchronic administration of the alkylating chemotherapeutic agent ifosfamide in different sites of the small and large rabbit intestine. MATERIALS AND METHODS:Twenty New Zealand White rabbits received intravenously every week, for 10 weeks, 0 (g...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2004.03.020

    authors: Ypsilantis P,Tentes L,Assimakopoulos SF,Kortsaris A,Scopa CD,Pitiakoudis M,Simopoulos C

    更新日期:2004-08-05 00:00:00

  • The promotion effect of novel magnetic nanoparticles on atherosclerotic plaque vulnerability in apolipoprotein E-/- mice.

    abstract::Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2019.03.002

    authors: Qu G,Wu Q,Zhao B,Miao J,Su L

    更新日期:2019-05-01 00:00:00

  • The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926).

    abstract:OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2005.09.014

    authors: Kilic B,Kruse M,Stahlmann R

    更新日期:2006-01-20 00:00:00

  • Beneficial cardio-renovascular effects of a low-molecular-weight heparin-derivative on adriamycin-induced glycosaminoglycanuria and tissue lipid abnormalities.

    abstract::The present work includes a study on the glycosaminoglycanuric condition induced by adriamycin (ADR, a chemotherapeutic agent) and the accompanying secondary hyperlipidemia, wherein the treatment with a low-molecular-weight heparin-derivative (LMWH), certoparin, is evaluated for its protective role (if any) on these p...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2005.02.009

    authors: Deepa PR,Varalakshmi P

    更新日期:2005-07-01 00:00:00

  • CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression.

    abstract::One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to sheep red blood cells (SRBCs) in mice. Immunosuppression occurs in concert with hepatomegaly and associated induction of several hepatic cytochrome P450 enz...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2003.11.016

    authors: Smialowicz RJ,Burgin DE,Williams WC,Diliberto JJ,Setzer RW,Birnbaum LS

    更新日期:2004-04-01 00:00:00

  • Inhibition of human erythrocyte Ca2+-ATPase by Zn2+.

    abstract::Recent investigations suggest that Ca2(+)-ATPase from fish gills is very sensitive to Zn2+ (Hogstrand et al., 1996. Am. J. Physiol. 270, R1141-R1147). The effect of free Zn2+ ion on the human erythrocyte plasma membrane Ca2(+)-ATPase was investigated to explore the possible extension of this finding to humans. Membran...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(99)00020-7

    authors: Hogstrand C,Verbost PM,Wendelaar Bonga SE

    更新日期:1999-04-15 00:00:00

  • Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe.

    abstract::The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2007.03.011

    authors: Attia SM

    更新日期:2007-06-03 00:00:00

  • Toxicity studies on trans-1,2-dichloroethylene.

    abstract::Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(77)90059-2

    authors: Freundt KJ,Liebaldt GP,Lieberwirth E

    更新日期:1977-04-01 00:00:00

  • Absorption, distribution, excretion and metabolism of a single oral dose of [14C]tri-o-cresyl phosphate (TOCP) in the male rat.

    abstract::A single oral dose of 50 mg/kg of [14C]TOCP was administered in corn oil to male rats. Three animals were sacrificed at each of 2, 6 and 12 h and 1, 2 and 5 days following dosing, and tissues and excreta were analyzed for 14C. Within 5 days, 63 and 36% of the dose were recovered in the urine and feces, respectively. I...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(90)90079-v

    authors: Abou-Donia MB,Nomeir AA,Bower JH,Makkawy HA

    更新日期:1990-12-17 00:00:00

  • Occupational health management and service for small-scale industries in Shanghai.

    abstract::Because occupational hazards of small-scale industries were severe and the occupational health management lagged behind in Shanghai, we selected some districts as experimental units to explore a model of community management and service for the occupational health in small-scale industries for controlling occupational...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2004.01.019

    authors: Wei L,Shi-Da W

    更新日期:2004-05-20 00:00:00

  • Occupational exposure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase.

    abstract::Toxicity and other relevant data for 30 organophosphate pesticides were evaluated to suggest inhalation occupational exposure limits (OELs), and to support development of a risk assessment strategy for organophosphates in general. Specifically, the value of relative potency analysis and the predictability of inhalatio...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-483x(00)00219-5

    authors: Storm JE,Rozman KK,Doull J

    更新日期:2000-09-07 00:00:00

  • Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration.

    abstract::Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method pr...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(88)90181-3

    authors: Barril JB,Vilanova E,Pellin MC

    更新日期:1988-04-01 00:00:00

  • Hypomethylation of mitochondrial D-loop and ND6 with increased mitochondrial DNA copy number in the arsenic-exposed population.

    abstract::Groundwater arsenic contamination has become a serious global concern due to its adverse effects on human health. Arsenic-induced reactive oxygen species trigger oxidative stress inside mitochondria, which initiate a cascade of events including altered mitochondrial (mt) membrane potential, uncoupling of electron tran...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2018.06.012

    authors: Sanyal T,Bhattacharjee P,Bhattacharjee S,Bhattacharjee P

    更新日期:2018-09-01 00:00:00

  • Food allergy--science and policy needs--The UK Food Standards Agency Research Programme.

    abstract::Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tox.2010.08.007

    authors: Buck J,Hattersley S,Kimber I

    更新日期:2010-12-30 00:00:00

  • Influence of a low-molecular-weight heparin derivative on the nitric oxide levels and apoptotic DNA damage in adriamycin-induced cardiac and renal toxicity.

    abstract::The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various tissues and under various pathological situations. In this study, the role of a low-molecular-weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage has been evaluated in the cardiac and rena...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2005.09.009

    authors: Deepa PR,Varalakshmi P

    更新日期:2006-01-16 00:00:00

  • Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.

    abstract::Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2014.07.003

    authors: Kawamura Y,Hayashi H,Masumura K,Numazawa S,Nohmi T

    更新日期:2014-10-03 00:00:00

  • Evaluation of the potential immunotoxicity of chlorinated drinking water in mice.

    abstract::Recent epidemiological studies have reported associations between the consumption of chlorinated drinking water and various types of human cancer; in addition, exposure to chlorine (Cl-) in drinking water has been reported to suppress certain immune functions in laboratory animals. The current studies were conducted t...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(97)00163-7

    authors: French AS,Copeland CB,Andrews DL,Wiliams WC,Riddle MM,Luebke RW

    更新日期:1998-01-16 00:00:00

  • Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice.

    abstract::Previous studies on the immunotoxicity of a complex mixture of polynuclear aromatic hydrocarbon (PAH) by-products from a manufactured gas plant indicated possible synergistic interactions which were investigated by determining the immunosuppressive effects of a reconstituted PAH mixture in female B6C3F1 mice challenge...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(95)03302-v

    authors: Harper N,Steinberg M,Safe S

    更新日期:1996-05-03 00:00:00

  • Effects of exposure to BDE-99 on oxidative status of liver and kidney in adult rats.

    abstract::Little is known about the potential toxicity of polybrominated diphenyl ethers (PBDEs) on hepatic and renal tissues. In this study, we investigated the modifications in endogenous antioxidant capacity and oxidative damage in liver and kidney of rats by exposure to one of the most persistent PBDE congeners, the 2,2',4,...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2010.03.006

    authors: Albina ML,Alonso V,Linares V,Bellés M,Sirvent JJ,Domingo JL,Sánchez DJ

    更新日期:2010-04-30 00:00:00

  • Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.

    abstract::Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2009.11.001

    authors: Guangwei X,Rongzhu L,Wenrong X,Suhua W,Xiaowu Z,Shizhong W,Ye Z,Aschner M,Kulkarni SK,Bishnoi M

    更新日期:2010-01-12 00:00:00

  • Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.

    abstract::The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(01)00372-9

    authors: Awney HA,Ghzlan HE,Sheweita SA,Mostafa MH

    更新日期:2001-06-21 00:00:00