Abstract:
:Cultures of the human cell line NHIK 3025 were exposed over an 18-month period to 0.5 mumol/1 potassium dichromate (K2Cr2O7) containing 1 mumol/1 hexavalent chromium. The chronically exposed cells increased their tolerance to K2Cr2O7 in comparison to control populations. The doubling time of the chronically exposed cell populations increased even in the absence of K2Cr2O7, but they did not change their morphology (light level), nor contain as many giant cells as newly exposed control populations. Cells returned to control medium for 6 months after 12-months exposure to K2Cr2O7 showed a gradual but incomplete reversal of these effects. The results are compared with those obtained from cells of non-tumour origin.
journal_name
Toxicologyjournal_title
Toxicologyauthors
White LR,Jakobsen K,Eik-Nes KBdoi
10.1016/0300-483x(81)90083-4subject
Has Abstractpub_date
1981-01-01 00:00:00pages
211-8issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(81)90083-4journal_volume
22pub_type
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