Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.


:Male Wistar rats injected i.p. with 30 mg Fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.






Reddy AC,Lokesh BR




Has Abstract


1996-01-22 00:00:00














  • Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model.

    abstract::The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...


    pub_type: 杂志文章


    authors: Mast TJ,Cukierski MA,Nau H,Hendrickx AG

    更新日期:1986-05-01 00:00:00

  • Response of alveolar macrophages to amiodarone and desethylamiodarone, in vitro.

    abstract::Administration of the antiarrhythmic drug amiodarone to humans or animals may result in lung damage. Amiodarone is metabolized to desethylamiodarone and other minor metabolites. Because amiodarone and the metabolites accumulate in the lungs, it is not possible to ascertain the role of each of these compounds in the in...


    pub_type: 杂志文章


    authors: Ogle CL,Reasor MJ

    更新日期:1990-05-31 00:00:00

  • Safety evaluation of an açai-fortified fruit and berry functional juice beverage (MonaVie Active(®)).

    abstract::The safety of an açai (Euterpe oleracea Mart.) pulp enriched fruit and berry juice, MonaVie Active®, fortified with the functional ingredient, glucosamine, was studied. The beverage was found not to be mutagenic, clastogenic, cytotoxic, or genotoxic, as determined by the bacterial reverse mutation assay, chromosomal a...


    pub_type: 杂志文章


    authors: Schauss AG,Clewell A,Balogh L,Szakonyi IP,Financsek I,Horváth J,Thuroczy J,Béres E,Vértesi A,Hirka G

    更新日期:2010-11-28 00:00:00

  • Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

    abstract::The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tried to alleviate the...


    pub_type: 杂志文章


    authors: Hsieh CL,Wang HE,Tsai WJ,Peng CC,Peng RY

    更新日期:2012-01-27 00:00:00

  • Inhalation of isopropanol: induction of activating and deactivating enzymes in rat kidney and liver. Increased microsomal metabolism of n-hexane.

    abstract::Rats were exposed to isopropanol by inhalation of 200,2000 and 8000 ppm for 2 weeks with a daily exposure of 6 h. A pilot group exposed to 8000 ppm was given a recovery period of 4 weeks. Kidney and liver microsomal metabolism of n-hexane was investigated in vitro concomitant with activities of cytochrome P-450 and GS...


    pub_type: 杂志文章


    authors: Zahlsen K,Aarstad K,Nilsen OG

    更新日期:1985-01-01 00:00:00

  • Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic functions.

    abstract::The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...


    pub_type: 杂志文章


    authors: Santoni G,Cantalamessa F,Mazzucca L,Romagnoli S,Piccoli M

    更新日期:1997-07-11 00:00:00

  • The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.

    abstract::This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...


    pub_type: 杂志文章


    authors: Fu J,Xia X,Liu Z,Wang Y,Wang Y,Shi Q,Song X,Song E,Song Y

    更新日期:2017-04-15 00:00:00

  • Prospective protective role of melatonin against arsenic-induced metabolic toxicity in Wistar rats.

    abstract::Subchronic exposure to arsenic is associated with alteration of glucose homeostasis. Arsenic treatment (as sodium arsenite) of male Wistar rats (weighing 130-150 g) at a dose of 5.55 mg kg(-1) body weight (equivalent to 35% of LD(50)) (i.p.) per day for a period of 30 days produced hypoglycemia, with associated increa...


    pub_type: 杂志文章


    authors: Pal S,Chatterjee AK

    更新日期:2005-03-01 00:00:00

  • [Toxicity by relay. III. Safety for the human consumer of the use of Carbadox, a feed additive for swine, as estimated by a 7 years relay toxicity on dogs].

    abstract::To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The...


    pub_type: 杂志文章


    authors: Ferrando R,Truhaut R,Raynaud JP,Spanoghe JP

    更新日期:1978-10-01 00:00:00

  • Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.

    abstract::Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...


    pub_type: 杂志文章


    authors: Guangwei X,Rongzhu L,Wenrong X,Suhua W,Xiaowu Z,Shizhong W,Ye Z,Aschner M,Kulkarni SK,Bishnoi M

    更新日期:2010-01-12 00:00:00

  • Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide.

    abstract::Repeated abuse of stimulant drugs, cocaine and amphetamine, is associated with extraneuronal dopamine accumulation in specific brain areas. Dopamine may be cytotoxic through the generation of reactive oxygen species, namely hydrogen peroxide (H2O2), resulting from dopamine oxidative metabolism. In this work, we studie...


    pub_type: 杂志文章


    authors: Cunha-Oliveira T,Rego AC,Morgadinho MT,Macedo T,Oliveira CR

    更新日期:2006-01-05 00:00:00

  • Cetaben versus clofibrate: comparison of toxicity and peroxisome proliferation in rats.

    abstract::Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on bo...


    pub_type: 杂志文章


    authors: Fort FL,Stein HH,Langenberg K,Lewkowski JP,Heyman IA,Kesterson JW

    更新日期:1983-11-01 00:00:00

  • Effects of S-adenosylmethionine on intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat.

    abstract::We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA(10) or 20 mg/kg per day-CyA(20) for 4 weeks) in rats. CyA treatment reduced the liver content of total gluta...


    pub_type: 杂志文章


    authors: Palomero J,Galán AI,Muñoz ME,González-Gallego J,Tuñón MJ,Jiménez R

    更新日期:2004-07-15 00:00:00

  • Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells.

    abstract::Cytochrome P450 (CYP) 2A13 is mainly expressed in the respiratory system and has the ability to metabolize aflatoxin B(1) (AFB(1)). However, the role of CYP2A13-mediated AFB(1) metabolism and its consequences in human lung epithelial cell is not clear. Therefore, the objectives of this study were to investigate the si...


    pub_type: 杂志文章


    authors: Yang XJ,Lu HY,Li ZY,Bian Q,Qiu LL,Li Z,Liu Q,Li J,Wang X,Wang SL

    更新日期:2012-10-28 00:00:00

  • Cisplatin nephrotoxicity: role of filtration and tubular transport of cisplatin in isolated perfused kidneys.

    abstract::Isolated perfused rat kidneys were used to determine the contribution of filtration and tubular transport of cisplatin to its nephrotoxicity. Perfusion of kidneys with 0.5 mM cisplatin concomitantly reduced tubular reabsorption of electrolytes and glomerular filtration rate in a time-dependent manner. These renal func...


    pub_type: 杂志文章


    authors: Miura K,Goldstein RS,Pasino DA,Hook JB

    更新日期:1987-05-01 00:00:00

  • Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice.

    abstract::Proliferation and differentiation of cells in female reproductive organs, the oviduct, uterus and vagina, are regulated by endogenous estrogen. In utero exposure to a synthetic estrogen, diethylstilbestrol (DES), induces vaginal clear-cell adenocarcinoma in humans. In mice, perinatal exposure to DES results in abnorma...


    pub_type: 杂志文章


    authors: Nakamura T,Miyagawa S,Katsu Y,Watanabe H,Mizutani T,Sato T,Morohashi K,Takeuchi T,Iguchi T,Ohta Y

    更新日期:2012-06-14 00:00:00

  • Factors affecting induction of lung aryl hydrocarbon hydroxylase in rats exposed to cigarette smoke.

    abstract::Induction of lung aryl hydrocarbon hydroxylase (AHH) activity has been studied in rats following their exposure to different regimes of cigarette smoke produced from tobacco and the tobacco substitute NSM. The rate of induction of AHH was maximal during the first 3 days of exposure to tobacco smoke. The frequency of e...


    pub_type: 杂志文章


    authors: Down WH,Chasseaud LF,Sacharin RM

    更新日期:1981-01-01 00:00:00

  • Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.

    abstract::Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Risk of VPA-induced hepatotoxicity is increased in patients with mitochondrial diseases and especially in patients with POLG1 gene mutations. We used a HepG2 cell in vitro model to investigate the effect of VPA on mitochondrial activity. Cells wer...


    pub_type: 杂志文章


    authors: Komulainen T,Lodge T,Hinttala R,Bolszak M,Pietilä M,Koivunen P,Hakkola J,Poulton J,Morten KJ,Uusimaa J

    更新日期:2015-05-04 00:00:00

  • The effect of nitrofen [4-(2,4-dichlorophenoxy)nitrobenzene] on the reproductive performance of male rats.

    abstract::Technical grade nitrofen was fed to 4 groups (25/group) of male Sprague-Dawley rats for 13 weeks at dietary concentrations of 0, 100, 500, or 2500 ppm. Untreated female rats of the same age and strain were mated with treated males and fertility, gestation, and lactation indices were monitored. After mating, males were...


    pub_type: 杂志文章


    authors: O'Hara GP,Chan PK,Harris JC,Burke SS,Smith JM,Hayes AW

    更新日期:1983-11-01 00:00:00

  • The Haber-Weiss reaction and mechanisms of toxicity.

    abstract::The concept that the highly reactive hydroxyl radical (HO) could be generated from an interaction between superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) was proposed (with Joseph Weiss) in Professor Haber's final paper published in 1934. Until it was recognized that free radicals are produced in biological syst...


    pub_type: 杂志文章,评审


    authors: Kehrer JP

    更新日期:2000-08-14 00:00:00

  • Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A.

    abstract::Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...


    pub_type: 杂志文章


    authors: Ljunggren SA,Iggland M,Rönn M,Lind L,Lind PM,Karlsson H

    更新日期:2016-03-10 00:00:00

  • A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.

    abstract:OBJECTIVE:This study was designed to investigate whether the mice treated with triptolide (TP) could disrupt the liver immune homeostasis, resulting in the inability of the liver to eliminate the harmful response induced by lipopolysaccharide (LPS). In addition, we explored whether apoptosis and necroptosis played a cr...


    pub_type: 杂志文章


    authors: Yuan Z,Zhang H,Hasnat M,Ding J,Chen X,Liang P,Sun L,Zhang L,Jiang Z

    更新日期:2019-02-15 00:00:00

  • Study of in vitro cytotoxicity of a water soluble organic arsenic compound, arsenosugar, in seaweed.

    abstract::In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...


    pub_type: 杂志文章


    authors: Sakurai T,Kaise T,Ochi T,Saitoh T,Matsubara C

    更新日期:1997-10-19 00:00:00

  • In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.

    abstract::Extracts from the leaves of Ginkgo biloba L. belong to the most widely used phytopharmaceuticals. In crude Ginkgo extracts, ginkgolic acids (GA) and related alkylphenols (e.g. cardanols and cardols) have been recognized as hazardous compounds with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties....


    pub_type: 杂志文章


    authors: Hecker H,Johannisson R,Koch E,Siegers CP

    更新日期:2002-08-15 00:00:00

  • Influence of microcystine-YR and nodularin on the activity of some glucosidases in mouse liver.

    abstract::Microcystine-YR (20 ug/kg bodyweight) and 8 ug/kg bodyweight of nodularin were intraperitoneally injected to 90 female Swiss mice. After 15, 30, 60 min and 24 h the changes were observed in the activity of some glucosidases in the complete cell homogenate and in the lysosomal, microsomal and cytosol fraction. Signific...


    pub_type: 杂志文章


    authors: Lankoff A,Kolataj A

    更新日期:2000-05-05 00:00:00

  • Calpeptin is neuroprotective against acrylamide-induced neuropathy in rats.

    abstract::The aim of this study is to explore the potent neuroprotective effect of calpeptin (CP) on neuron damage induced by acrylamide (ACR) and its mechanism. Behavioural indicators such as hind limb splay, rota-rod performance, and gait analysis were assessed weekly to evaluate neurobehavioural changes after ACR and/or CP a...


    pub_type: 杂志文章


    authors: Su B,Guan Q,Wang M,Liu N,Wei X,Wang S,Yang X,Jiang W,Xu M,Yu S

    更新日期:2018-05-01 00:00:00

  • Central/peripheral nervous system and immune responses.

    abstract::Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...


    pub_type: 杂志文章,评审


    authors: Lawrence DA,Kim D

    更新日期:2000-01-17 00:00:00

  • Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin.

    abstract::Long-term exposure to pharmacological agents can select for cells that overexpress efflux transporters. We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced...


    pub_type: 杂志文章


    authors: Vallet CM,Marquez B,Nhiri N,Anantharajah A,Mingeot-Leclercq MP,Tulkens PM,Lallemand JY,Jacquet E,Van Bambeke F

    更新日期:2011-12-18 00:00:00

  • Studies on the effect of chronic L-triiodothyronine (T3) treatment on brain Na+,K+-ATPase activity in the mature rat.

    abstract::Mature rats were dosed with T3 by different routes and dose-levels at either 0.1 mg/kg for 14 days s.c. (Group A), 1 mg/kg for 3 alternative days i.p. (Group B), 5 mg/kg for 14 days p.o. (Group C), or with propylthiouracil (PTU 50 mg/day for 14 days p.o.-Group D). Measurement of cerebellar and striatal NA+,K+-ATPase a...


    pub_type: 杂志文章


    authors: Atterwill CK,Brown CG,Collins P

    更新日期:1987-01-01 00:00:00

  • Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.

    abstract::Novel dexrazoxane derivative JR-311 was prepared to investigate structure-activity relationships and mechanism(s) of protection against anthracycline cardiotoxicity. Its cardioprotective, antiproliferative, iron (Fe) chelation and inhibitory and/or depletory activities on topoisomerase IIbeta (TOP2B) were examined and...


    pub_type: 杂志文章


    authors: Bures J,Jirkovska A,Sestak V,Jansova H,Karabanovich G,Roh J,Sterba M,Simunek T,Kovarikova P

    更新日期:2017-12-01 00:00:00