Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.

abstract：:Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on bo...

journal_title：Toxicology

authors： Fort FL,Stein HH,Langenberg K,Lewkowski JP,Heyman IA,Kesterson JW

更新日期：1983-11-01 00:00:00

abstract：:Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Benz[a]anthracene (B[a]A), benzo[...

journal_title：Toxicology

authors： Vinggaard AM,Hnida C,Larsen JC

更新日期：2000-04-14 00:00:00

abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...

journal_title：Toxicology

authors： Tan W,Barnett JV,Hehn GM,Quay SC,Galper JB

更新日期：1991-01-01 00:00:00

abstract：:Sixteen polycyclic aromatic hydrocarbons (PAHs) were screened for their ability to be directly cytotoxic to a cell line from the rainbow trout gill, RTgill-W1. Exposure times of 2 h or less were sufficient for direct cytotoxicity to be detected, which appeared to be caused by a common mechanism, the general perturbati...

journal_title：Toxicology

authors： Schirmer K,Dixon DG,Greenberg BM,Bols NC

更新日期：1998-05-15 00:00:00

abstract：:Previous studies have reported that maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces socioemotional and cognitive disturbances in rat offspring. In the present study, the effects of maternal TCDD exposure on putative inhibitory interneurons were investigated in the medial prefrontal cortex (mPFC...

journal_title：Toxicology

authors： Nguyen MN,Nishijo M,Nguyen AT,Bor A,Nakamura T,Hori E,Nakagawa H,Ono T,Nishijo H

更新日期：2013-12-06 00:00:00

abstract：:We determined the threshold concentration of sarin vapor exposure producing miosis in African green monkeys (Chlorocebus aethiops). Monkeys (n=8) were exposed to a single concentration of sarin (0.069-0.701mg/m3) for 10min. Changes in pupil size were measured from photographs taken before and after the exposure. Sarin...

journal_title：Toxicology

authors： Genovese RF,Benton BJ,Oubre JL,Fleming PJ,Jakubowski EM,Mioduszewski RJ

更新日期：2008-02-28 00:00:00

abstract：:The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic r...

journal_title：Toxicology

authors： Friedman SL

更新日期：2008-12-30 00:00:00

abstract：:Little is known about the potential toxicity of polybrominated diphenyl ethers (PBDEs) on hepatic and renal tissues. In this study, we investigated the modifications in endogenous antioxidant capacity and oxidative damage in liver and kidney of rats by exposure to one of the most persistent PBDE congeners, the 2,2',4,...

journal_title：Toxicology

authors： Albina ML,Alonso V,Linares V,Bellés M,Sirvent JJ,Domingo JL,Sánchez DJ

更新日期：2010-04-30 00:00:00

abstract：:The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...

journal_title：Toxicology

authors： Johnson MK,Vilanova E,Read DJ

更新日期：1989-01-01 00:00:00

abstract：UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...

journal_title：Toxicology

authors： Oubaassine R,Bilbault P,Roegel JC,Alexandre E,Sigrist S,Lavaux T,Jaeger A,Pinget M,Kessler L

更新日期：2006-07-25 00:00:00

abstract：:Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory and anti-oxidant prope...

journal_title：Toxicology

authors： Shen T,Shang Y,Wu Q,Ren H

更新日期：2020-09-01 00:00:00

abstract：:Toxicity and other relevant data for 30 organophosphate pesticides were evaluated to suggest inhalation occupational exposure limits (OELs), and to support development of a risk assessment strategy for organophosphates in general. Specifically, the value of relative potency analysis and the predictability of inhalatio...

journal_title：Toxicology

authors： Storm JE,Rozman KK,Doull J

更新日期：2000-09-07 00:00:00

abstract：:Long-term cadmium exposure leads to mitochondrial dysfunction in the proximal tubular epithelial cells. Mitochondrial DNA deletion may contribute to the pathogenesis of cadmium-induced nephropathy. The aim of our study is to clarify the accumulation of mitochondrial DNA deletion and mitochondrial dysfunction in the re...

journal_title：Toxicology

authors： Takaki A,Jimi S,Segawa M,Hisano S,Takebayashi S,Iwasaki H

更新日期：2004-10-15 00:00:00

abstract：:Technical grade nitrofen was fed to 4 groups (25/group) of male Sprague-Dawley rats for 13 weeks at dietary concentrations of 0, 100, 500, or 2500 ppm. Untreated female rats of the same age and strain were mated with treated males and fertility, gestation, and lactation indices were monitored. After mating, males were...

journal_title：Toxicology

authors： O'Hara GP,Chan PK,Harris JC,Burke SS,Smith JM,Hayes AW

更新日期：1983-11-01 00:00:00

abstract：:Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pathway was involved in BPA-induced Sertoli cells injury via t...

journal_title：Toxicology

authors： Qian W,Zhu J,Mao C,Liu J,Wang Y,Wang Q,Liu Y,Gao R,Xiao H,Wang J

更新日期：2014-10-03 00:00:00

abstract：:The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-am...

journal_title：Toxicology

authors： Roux F,Treich I,Fournier E

更新日期：1980-01-01 00:00:00

abstract：:The fetotoxicity of nitrofen and 5 analogous diphenyl ethers was compared in mice, using survival on postnatal day 5 to evaluate prenatal and perinatal toxicity. The effect of each chemical on the Harderian gland weight of surviving pups was also assessed, since decreased Harderian gland weight is seen in nitrofen-exp...

journal_title：Toxicology

authors： Francis BM

更新日期：1986-09-01 00:00:00

abstract：:The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg...

journal_title：Toxicology

authors： Levine BS,Preache MM,Pergament E

更新日期：1980-01-01 00:00:00

abstract：:Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of...

journal_title：Toxicology

authors： Forkert PG,Sylvestre PL,Poland JS

更新日期：1985-05-01 00:00:00

abstract：:The majority of human P450-dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, quantitatively or qualitatively altered or enhanced metabolism. The latter situation is due to stable duplication, multiduplication or amplification of active genes, most likely in response to di...

journal_title：Toxicology

authors： Ingelman-Sundberg M

更新日期：2002-12-27 00:00:00

abstract：:Metallothionein, a low molecular weight cadmium-binding protein, has been determined for the first time in urine of "itai-itai" disease patients and other Japanese women environmentally exposed to cadmium. On a group basis, the urinary metallothionein levels of "itai-itai" disease patients and suspected patients were ...

journal_title：Toxicology

authors： Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

更新日期：1981-01-01 00:00:00

abstract：:Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...

journal_title：Toxicology

authors： Valentovic MA,Ball JG,Anestis DK,Beers KW,Madan E,Hubbard JL,Rankin GO

更新日期：1992-11-01 00:00:00

abstract：:Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while merc...

journal_title：Toxicology

authors： Imura N,Miura K,Inokawa M,Nakada S

更新日期：1980-01-01 00:00:00

abstract：:The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...

journal_title：Toxicology

authors： Allen DD,Orvig C,Yokel RA

更新日期：1994-09-06 00:00:00

abstract：:Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...

journal_title：Toxicology

authors： Gehrs BC,Smialowicz RJ

更新日期：1999-05-03 00:00:00

abstract：:Quantum dots (QDs) are potentially beneficial semi-conductor nanocrystals for use in diagnostics and therapeutics. The chemical composition of QDs however, has raised concerns as to their potential toxicity. Although a thorough examination using specific biochemical endpoints is necessary to assess QD toxicity, an und...

journal_title：Toxicology

authors： Clift MJ,Brandenberger C,Rothen-Rutishauser B,Brown DM,Stone V

更新日期：2011-08-15 00:00:00

abstract：:Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...

journal_title：Toxicology

authors： Kambouris SJ,Chaudhary AK,Blair IA

更新日期：1996-10-28 00:00:00

abstract：:The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation ...

journal_title：Toxicology

authors： Ema M,Kurosaka R,Amano H,Ogawa Y

更新日期：1995-02-27 00:00:00

abstract：:Antimony compounds are widely used in various manufacturing and semiconducting industries. Previously, it has been shown that antimony trichloride (SbCl3) elevates sister chromatid exchange (SCE) rates in V79 cells after a 28-h incubation. However, only limited data on its genotoxic effects are available so far. The p...

journal_title：Toxicology

authors： Huang H,Shu SC,Shih JH,Kuo CJ,Chiu ID

更新日期：1998-08-21 00:00:00

abstract：:A single intraperitoneal injection of 10(-6.5) mol lanthanum chloride/g body wt (44 mg metal/kg body wt) into pregnant mice reduced the number of successful pregnancies and the average litter size. The most susceptible periods of pregnancy were peri-implantation (days 4 and 6) and near-term period (days 14 and 16). In...

journal_title：Toxicology

authors： Abramczuk JW

更新日期：1985-03-29 00:00:00