Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.


:Male Wistar rats injected i.p. with 30 mg Fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.






Reddy AC,Lokesh BR




Has Abstract


1996-01-22 00:00:00














  • Urinary taurine as a non-invasive marker of aflatoxin B1-induced hepatotoxicity: success and failure.

    abstract::The usefulness of urinary taurine as a non-invasive measure of hepatotoxicity of aflatoxin B1 (AFB1) was evaluated: changes in urinary taurine were characterized in a dose-response, acute toxicity experiment and in two sub-chronic, low dose exposure experiments. Urine of young, male, F344 rats was collected for 4 days...


    pub_type: 杂志文章


    authors: Maxuitenko YY,North WG,Roebuck BD

    更新日期:1997-03-28 00:00:00

  • Assessment of the sensitization potential of five metal salts in the murine local lymph node assay.

    abstract::The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO4, K2Cr2O7, CoCl2, Na2PtCl6 and BeSO4, salts of metals which have all been associated with allergic contact dermatitis and either...


    pub_type: 杂志文章


    authors: Mandervelt C,Clottens FL,Demedts M,Nemery B

    更新日期:1997-06-06 00:00:00

  • Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells.

    abstract::Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...


    pub_type: 杂志文章


    authors: Akhtar MJ,Ahamed M,Kumar S,Siddiqui H,Patil G,Ashquin M,Ahmad I

    更新日期:2010-10-09 00:00:00

  • Short-term toxicity of allyl alcohol in rats.

    abstract::Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...


    pub_type: 杂志文章


    authors: Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

    更新日期:1978-02-01 00:00:00

  • Protection from inorganic mercury effects on the in vivo dopamine release by ionotropic glutamate receptor antagonists and nitric oxide synthase inhibitors.

    abstract::The possible role of ionotropics glutamate receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective NMDA and AMPA/Kainate receptors antagonists dizocilpine (MK-801), D (-)-2-amino-5-phoshonopentanoic acid ...


    pub_type: 杂志文章


    authors: Vidal L,Durán R,Faro LF,Campos F,Cervantes RC,Alfonso M

    更新日期:2007-09-05 00:00:00

  • Differences in neonatal neurotoxicity of brominated flame retardants, PBDE 99 and TBBPA, in mice.

    abstract::Flame retardants such as polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A are used as flame retardants and detected in the environmental, wildlife species and human tissues. Exposure to PBDEs during the neonatal development of the brain has been shown to affect behavior and learning and memory in adult ...


    pub_type: 杂志文章


    authors: Viberg H,Eriksson P

    更新日期:2011-10-28 00:00:00

  • EEG as a neurotoxicological indicator.

    abstract::In living organisms both chemical agents and physical factors [16] may produce neurophysiological change that affects EEG activity. EEG signals are very suitable for non-invasive measurement of CNS reactions, but quite complicated equipment is necessary for measurement and analysis. We have implemented a system that p...


    pub_type: 杂志文章


    authors: Kubát J,Formánek J,Fuchs A,Rehák P,Zajícek P,Dvorák J,Vanícková M

    更新日期:1988-05-01 00:00:00

  • Non-linear model analysis of the relationship between cholinesterase activity in rats exposed to 2, 2-dichlorovinyl dimethylphosphate (dichlorvos) and its metabolite concentrations in urine.

    abstract::Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, howev...


    pub_type: 杂志文章


    authors: Sato H,Ito Y,Hanai C,Nishimura M,Ueyama J,Kamijima M

    更新日期:2021-01-15 00:00:00

  • Effect of dietary antioxidants on benzo[a]pyrene metabolism in rat liver microsomes.

    abstract::Feeding of rats with 1% ethoxyquin (EQ) and butylated hydroxytoluene (BHT) but not butylated hydroxyanisole (BHA) increases the formation rate of benzo[a]pyrene (BP)-4,5-dihydrodiol from BP in hepatic microsomes. The production of other BP-dihydrodiols and of BP phenols is decreased after treatment with EQ, BHT and BH...


    pub_type: 杂志文章


    authors: Kahl R,Kahl GF

    更新日期:1983-01-01 00:00:00

  • The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control.

    abstract::Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...


    pub_type: 杂志文章


    authors: Myers JM,Antholine WE,Myers CR

    更新日期:2011-03-15 00:00:00

  • Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression.

    abstract::In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...


    pub_type: 杂志文章


    authors: Kauffmann HM,Pfannschmidt S,Zöller H,Benz A,Vorderstemann B,Webster JI,Schrenk D

    更新日期:2002-02-28 00:00:00

  • Influence of microcystine-YR and nodularin on the activity of some glucosidases in mouse liver.

    abstract::Microcystine-YR (20 ug/kg bodyweight) and 8 ug/kg bodyweight of nodularin were intraperitoneally injected to 90 female Swiss mice. After 15, 30, 60 min and 24 h the changes were observed in the activity of some glucosidases in the complete cell homogenate and in the lysosomal, microsomal and cytosol fraction. Signific...


    pub_type: 杂志文章


    authors: Lankoff A,Kolataj A

    更新日期:2000-05-05 00:00:00

  • Distribution of terbium and increase in calcium concentrations in organs of mice administered with terbium chloride.

    abstract::To investigate the biological effects of terbium (Tb), male mice were intraperitoneally administered with TbCl3 at doses of 10, 50, or 250 mg Tb/kg. The Tb distribution in organs was determined after 18-20 h of injection by using a spectrofluorometer. The concentrations of Ca, Mg, Fe, and Zn in various organs were det...


    pub_type: 杂志文章


    authors: Shinohara A,Chiba M

    更新日期:1991-02-11 00:00:00

  • Histopathological and biochemical changes in the liver and testes of desert gerbil, after repeated exposures of Thimet (phorate).

    abstract::Intraperitoneal administration of Thimet (0.6 mg/kg) on alternate days for a period of 30 days produced various pathological and biochemical changes in the liver and testes of male gerbils. Histology of the liver showed necrosis, enlarged hepatocytes and fatty degeneration. Histological changes seen in the testes were...


    pub_type: 杂志文章


    authors: Saxena AK,Sarin K

    更新日期:1980-01-01 00:00:00

  • Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat.

    abstract::Methoxy-, ethoxy- and n-butoxy acetic acids, known urinary metabolites of the corresponding alkoxyethanol solvents, were administered by gavage to rats as a single oral dose equimolar with 500, 250 or 100 mg 2-methoxyethanol/kg body weight. Testicular weight and morphology were monitored over a 14-day period post-trea...


    pub_type: 杂志文章


    authors: Foster PM,Lloyd SC,Blackburn DM

    更新日期:1987-01-01 00:00:00

  • PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase.

    abstract::Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...


    pub_type: 杂志文章


    authors: Fan LQ,Brown-Borg H,Brown S,Westin S,Mode A,Corton JC

    更新日期:2004-10-15 00:00:00

  • Studies on brain lesions after administration of monosodium L-glutamate to mice. II. Absence of brain damage following administration of monosodium L-glutamate in the diet.

    abstract::The effects of monosodium L-glutamate (MSG) on the brain of mice were examined by light-microscopy under the intended conditions of use of this material. Basal diet containing 5, 10 or 15% w/w MSG was fed to pregnant, lactating and weanling mice ad libitum, resulting in the ingestion of 14.0, 42.8 or 42.0 g/kg body wt...


    pub_type: 杂志文章


    authors: Takasaki Y

    更新日期:1978-04-01 00:00:00

  • Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G.

    abstract::The trichothecenes are a group of mycotoxins that target leukocytes and have a wide range of immunomodulatory effects. Differential display analysis was applied to assess the effects of the trichothecenes deoxynivalenol (vomitoxin, DON) and satratoxin G (SG), on mRNA in the RAW 264.7 macrophage cell line. Cells were i...


    pub_type: 杂志文章


    authors: Chung YJ,Yang GH,Islam Z,Pestka JJ

    更新日期:2003-04-15 00:00:00

  • Safety evaluation of an açai-fortified fruit and berry functional juice beverage (MonaVie Active(®)).

    abstract::The safety of an açai (Euterpe oleracea Mart.) pulp enriched fruit and berry juice, MonaVie Active®, fortified with the functional ingredient, glucosamine, was studied. The beverage was found not to be mutagenic, clastogenic, cytotoxic, or genotoxic, as determined by the bacterial reverse mutation assay, chromosomal a...


    pub_type: 杂志文章


    authors: Schauss AG,Clewell A,Balogh L,Szakonyi IP,Financsek I,Horváth J,Thuroczy J,Béres E,Vértesi A,Hirka G

    更新日期:2010-11-28 00:00:00

  • Excessive hydrogen peroxide enhances the attachment of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts.

    abstract::Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42 in the lenses of UPL rats, which then leads to lens opacification. In add...


    pub_type: 杂志文章


    authors: Nagai N,Ito Y

    更新日期:2014-01-06 00:00:00

  • Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis.

    abstract::It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and nitromethane. Aldo-keto reductases (AKRs) are enz...


    pub_type: 杂志文章


    authors: Su JG,Liao PJ,Huang MC,Chu WC,Lin SC,Chang YJ

    更新日期:2008-02-28 00:00:00

  • Alterations in c-Src/HER1 and estrogen receptor α signaling pathways in mammary gland and tumors of hexachlorobenzene-treated rats.

    abstract::Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation ...


    pub_type: 杂志文章


    authors: Peña D,Pontillo C,García MA,Cocca C,Alvarez L,Chiappini F,Bourguignon N,Frahm I,Bergoc R,Kleiman de Pisarev D,Randi A

    更新日期:2012-03-11 00:00:00

  • Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats.

    abstract::Fischer 344 rats were exposed to filtered air (controls) or to 0.12, 0.5, or 1.0 ppm of ozone for 6 h/day, 5 days/week, for 20 months. We examined lung collagen deposition and metabolism in tissue from these animals to determine whether chronic exposure of rats to ozone causes pulmonary fibrosis. We observed excess st...


    pub_type: 杂志文章


    authors: Last JA,Gelzleichter T,Harkema J,Parks WC,Mellick P

    更新日期:1993-11-12 00:00:00

  • Immunological basis of toxic oil syndrome (TOS).

    abstract::The toxic oil syndrome (TOS), a multisystemic disease, that occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline. Due to the clinical course of the disease, immunopathological mechanisms have been suspected but a direct connection was never demonstrated. To analyse this poss...


    pub_type: 杂志文章


    authors: Gallardo S,del Pozo V,Cárdaba B,de Andrés B,Martín-Orozco E,Fernandez JC,Tramón P,Posada M,Abaitua I,Palomino P

    更新日期:1994-11-11 00:00:00

  • Effects of extended sidestream smoke exposure on components of the C-fiber axon reflex.

    abstract::We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to...


    pub_type: 杂志文章


    authors: Joad JP,Avadhanam KP,Watt KC,Kott KS,Bric JM,Pinkerton KE

    更新日期:1996-09-02 00:00:00

  • Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.

    abstract::Novel substituted phenoxyalkyl pyridinium oximes, previously shown to reactivate brain cholinesterase in rats treated with high sublethal dosages of surrogates of sarin and VX, were tested for their ability to prevent mortality from lethal doses of these two surrogates. Rats were treated subcutaneously with 0.6mg/kg n...


    pub_type: 杂志文章


    authors: Chambers JE,Meek EC,Bennett JP,Bennett WS,Chambers HW,Leach CA,Pringle RB,Wills RW

    更新日期:2016-01-02 00:00:00

  • Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe.

    abstract::The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...


    pub_type: 杂志文章


    authors: Attia SM

    更新日期:2007-06-03 00:00:00

  • Chloral hydrate enhances ethanol-induced inhibition of methanol oxidation in mice.

    abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...


    pub_type: 杂志文章


    authors: Faci A,Plaa GL,Sharkawi M

    更新日期:1998-11-02 00:00:00

  • In vivo and in vitro toxicity of newly synthesized monofunctional sulfur mustard derivatives.

    abstract::The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...


    pub_type: 杂志文章


    authors: Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska A

    更新日期:1996-04-15 00:00:00

  • Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity.

    abstract::Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...


    pub_type: 杂志文章


    authors: Waterfield CJ,Turton JA,Scales MD,Timbrell JA

    更新日期:1993-01-29 00:00:00