Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.

Abstract:

:Male Wistar rats injected i.p. with 30 mg Fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.

journal_name

Toxicology

journal_title

Toxicology

authors

Reddy AC,Lokesh BR

doi

10.1016/0300-483x(95)03199-p

subject

Has Abstract

pub_date

1996-01-22 00:00:00

pages

39-45

issue

1

eissn

0300-483X

issn

1879-3185

pii

0300483X9503199P

journal_volume

107

pub_type

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