Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats.

abstract：:The cardiovascular toxin allylamine (3-aminopropene) has been shown to concentrate in elastic and muscular tissues. In this study the 14C-moiety of [14C]allylamine was traced in aortas of adult Sprague-Dawley rats after intravenously injecting 30 microCi of [14C]allylamine (spec. act. = 0.4 mCi/mM). At 5, 10, 15 and 2...

journal_title：Toxicology

authors： Hysmith RM,Boor PJ

更新日期：1985-06-14 00:00:00

abstract：:The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...

journal_title：Toxicology

authors： Vaas S,Kreft L,Schwarz M,Braeuning A

更新日期：2014-11-05 00:00:00

abstract：:The usefulness of measuring serum bile acid concentrations by RIA in a number of acute experimental liver injuries of rats was assessed by comparing the concentrations with the results of some of the routinely employed methods of examining hepatotoxic changes. Centrilobular liver cell injury produced by CCl4 revealed ...

journal_title：Toxicology

authors： Gopinath C,Prentice DE,Street AE,Crook D

更新日期：1980-01-01 00:00:00

abstract：:The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, ind...

journal_title：Toxicology

authors： Ozer J,Ratner M,Shaw M,Bailey W,Schomaker S

更新日期：2008-03-20 00:00:00

abstract：:Aromatase enzyme plays a central role in steroidogenesis by converting androgens to estrogens and has been proposed as an important molecular target for many environmental endocrine disrupters chemicals. In this study, we have screened 30 selected pesticides with known, unknown or supposed effects on aromatase activit...

journal_title：Toxicology

authors： Laville N,Balaguer P,Brion F,Hinfray N,Casellas C,Porcher JM,Aït-Aïssa S

更新日期：2006-11-10 00:00:00

abstract：:Cyclophosphamide (CP) is a known immunomodulating agent. When presented to either late stage chick embryos (e.g. 18 days of incubation (DI] or neonatal chicks. CP induces selective B cell damage resulting in humoral immunosuppression in chickens. The present study was undertaken in order to provide further insights in...

journal_title：Toxicology

authors： Misra RR,Bloom SE

更新日期：1991-03-11 00:00:00

abstract：:Role of chromium(III) in biological systems is controversial and no significant conclusions can be arrived with the available data. Chromium(VI) enters in to the cell readily and gets reduced to form stable chromium(III) complexes. Chromium(III) complexes react slowly and were considered non-toxic. Recent studies sugg...

journal_title：Toxicology

authors： Raja NS,Nair BU

更新日期：2008-09-29 00:00:00

abstract：:Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...

journal_title：Toxicology

authors： Bull RJ,Sanchez IM,Nelson MA,Larson JL,Lansing AJ

更新日期：1990-09-01 00:00:00

abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

journal_title：Toxicology

authors： Qu G,Wu Q,Zhao B,Miao J,Su L

更新日期：2019-05-01 00:00:00

abstract：:Exposure of rats to 0.1 and 0.5 mg Cd/kg subcutaneously (s.c.) thrice weekly for 5 weeks resulted in an accumulation of cadmium in the liver in concentrations of 40 and 95 micrograms/g tissue, respectively, and a microsomal burden of Cd amounting to approx. 2-3% of the retained cadmium. The cytoplasm contained about 8...

journal_title：Toxicology

authors： Klimczak J,Wiśniewska-Knypl JM,Kolakowski J

更新日期：1984-09-14 00:00:00

abstract：:The popliteal lymph node assay (PLNA) is being considered as a tool to predict the potential of drugs for inducing systemic autoimmune and hypersensitivity reactions. Despite the use of different technical approaches and the evaluation of over 130 compounds, the sensitivity and specificity of the PLNA are still debata...

journal_title：Toxicology

authors： Ravel G,Christ M,Horand F,Descotes J

更新日期：2004-08-05 00:00:00

abstract：:Zearalenone (ZEN) is a non-steroidal oestrogenic mycotoxin produced by several Fusarium species growing on cereals. ZEN and its metabolites bind to human oestrogen receptors and hence display oestrogenic and anabolic properties. Several lines of investigation suggest that ZEN may be genotoxic in vivo. ZEN damages DNA ...

journal_title：Toxicology

authors： Abid-Essefi S,Baudrimont I,Hassen W,Ouanes Z,Mobio TA,Anane R,Creppy EE,Bacha H

更新日期：2003-11-05 00:00:00

abstract：:Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure. In mammals, it exerts multiple toxic effects and has been classified as a human carcinogen by the International Agency for Research on Cancer. Cadmium affects cell proliferation, differen...

journal_title：Toxicology

authors： Waisberg M,Joseph P,Hale B,Beyersmann D

更新日期：2003-11-05 00:00:00

abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...

journal_title：Toxicology

authors： Warshawsky D,Barkley W,Miller ML,LaDow K,Andringa A

更新日期：1994-11-11 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and se...

journal_title：Toxicology

authors： Wang H,Zhang H,Tang L,Chen H,Wu C,Zhao M,Yang Y,Chen X,Liu G

更新日期：2013-01-07 00:00:00

abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...

journal_title：Toxicology

authors： Reinhart PG,Bassett DJ,Bhalla DK

更新日期：1998-05-15 00:00:00

abstract：:The effects of acute ethanol and acetaldehyde treatment on cell proliferation, cell adhesion capacity, neutral red incorporation into lysosomes, glutathione content, protein sulfhydryl compounds, lipid peroxidation, inner mitochondrial membrane integrity (MTT test), lactate dehydrogenase activity (LDH) and ultrastruct...

journal_title：Toxicology

authors： Olivares IP,Bucio L,Souza V,Cárabez A,Gutiérrez-Ruiz MC

更新日期：1997-06-27 00:00:00

abstract：:The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis were observed, but herein, analysis o...

journal_title：Toxicology

authors： Fiorito F,Ciarcia R,Granato GE,Marfe G,Iovane V,Florio S,De Martino L,Pagnini U

更新日期：2011-12-18 00:00:00

abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...

journal_title：Toxicology

authors： Wang CC,Chen LG,Yang LL

更新日期：2001-11-30 00:00:00

abstract：:Studies showed that certain cytotoxicity assays were not suitable for assessing nanoparticle (NP) toxicity. We evaluated a lactate dehydrogenase (LDH) assay for assessing copper (Cu-40, 40nm), silver (Ag-35, 35nm; Ag-40, 40nm), and titanium dioxide (TiO(2)-25, 25nm) NPs by examining their potential to inactivate LDH a...

journal_title：Toxicology

authors： Han X,Gelein R,Corson N,Wade-Mercer P,Jiang J,Biswas P,Finkelstein JN,Elder A,Oberdörster G

更新日期：2011-09-05 00:00:00

abstract：:The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...

journal_title：Toxicology

authors： Weaver JL,Staten D,Swann J,Armstrong G,Bates M,Hastings KL

更新日期：2003-12-01 00:00:00

abstract：:This review presents a brief and non-comprehensive overview of a representative sampling of some of the broad array of toxicology-related learning, tutorial and information resources now becoming widely available to educators, health professionals, students and the general public in digital media and/or via the Intern...

journal_title：Toxicology

authors： Sharpe JF,Eaton DL,Marcus CB

更新日期：2001-01-12 00:00:00

abstract：:The mouse lymphoma thymidine kinase assay (MLA) has been optimized to quantitatively determine the in vitro mutagenicity of cigarette mainstream smoke particulate phase. To test whether the MLA is able to discriminate between different cigarette types, specially constructed cigarettes each containing a single tobacco ...

journal_title：Toxicology

authors： Schramke H,Meisgen TJ,Tewes FJ,Gomm W,Roemer E

更新日期：2006-10-29 00:00:00

abstract：:Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and during lactation until 21 days post partum. An effect on live litter size was noted at the higher doses as was an increased tendency for sperm positive females to fail to produce a litt...

journal_title：Toxicology

authors： Carmichael NG,Winder C,Lewis PD

更新日期：1981-01-01 00:00:00

abstract：:Clinical trials with antidotes are difficult to perform for a variety of practical, ethical, and financial reasons. As acute poisoning is a rare event, the commercial interest in basic and clinical research is low. Poisoned patients are usually not available for normal clinical trial procedures and, if they are, they ...

journal_title：Toxicology

authors： Steffen C

更新日期：2007-04-20 00:00:00

abstract：:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...

journal_title：Toxicology

authors： Gilmour MI

更新日期：1995-12-28 00:00:00

abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...

journal_title：Toxicology

authors： Cohen SM

更新日期：1995-09-01 00:00:00

abstract：:The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...

journal_title：Toxicology

authors： Feron VJ,Kruysse A,Immel HR,Til HP

更新日期：1979-12-01 00:00:00

abstract：:Some workers have suggested that 6 days xylitol administration to rats results in hepatic dysfunction. In our study xylitol was administered to rats by daily gastric intubation for a period of 14 days. Dose levels were 1.25, 2.5, 5 and 10 g/kg. During treatment (2, 5 and 14 days), animals were submitted to careful cli...

journal_title：Toxicology

authors： Truhaut,Coquet B,Fouillet X,Galland L,Guyot D,Rouaud JL,Long DW

更新日期：1977-08-01 00:00:00

abstract：:Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...

journal_title：Toxicology

authors： Karrow NA,McCay JA,Brown RD,Musgrove DL,Guo TL,Germolec DR,White KL Jr

更新日期：2005-04-01 00:00:00