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NATURE文献大全abstract::The retinotectal projection has long been studied experimentally and theoretically, as a model for the formation of topographic brain maps. Neighbouring retinal ganglion cells (RGCs) project their axons to neighbouring positions in the optic tectum, thus re-establishing a continuous neural representation of visual spa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06816
更新日期:2008-04-17 00:00:00
abstract::Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational charact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14416
更新日期:2015-05-14 00:00:00
abstract::Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00906
更新日期:2002-08-01 00:00:00
abstract::Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321517a0
更新日期:1986-05-29 00:00:00
abstract::All forms of locomotion are repetitive motor activities that require coordinated bilateral activation of muscles. The executive elements of locomotor control are networks of spinal neurons that determine gait pattern through the sequential activation of motor-neuron pools on either side of the body axis. However, litt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12286
更新日期:2013-08-01 00:00:00
abstract::How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05321
更新日期:2006-12-14 00:00:00
abstract::A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352301a0
更新日期:1991-07-25 00:00:00
abstract::The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08941
更新日期:2010-03-25 00:00:00
abstract::A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02218
更新日期:2004-01-01 00:00:00
abstract::The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07810
更新日期:2009-03-12 00:00:00
abstract::The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35015572
更新日期:2000-06-15 00:00:00
abstract::The biosynthesis of several protein cofactors is subject to feedback regulation by riboswitches. Flavin mononucleotide (FMN)-specific riboswitches, also known as RFN elements, direct expression of bacterial genes involved in the biosynthesis and transport of riboflavin (vitamin B(2)) and related compounds. Here we pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07642
更新日期:2009-03-12 00:00:00
abstract::Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10742
更新日期:2012-01-09 00:00:00
abstract::Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/2281062a0
更新日期:1970-12-12 00:00:00
abstract::Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09471
更新日期:2010-11-25 00:00:00
abstract::Quantum information science involves the storage, manipulation and communication of information encoded in quantum systems, where the phenomena of superposition and entanglement can provide enhancements over what is possible classically. Large-scale quantum information processors require stable and addressable quantum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06118
更新日期:2007-09-06 00:00:00
abstract::We have investigated age-related reactivation of the X chromosome by devising a model in which reactivation of a single gene in one cell among many can be identified. We have used mice with an X-autosomal translocation giving consistent non-random inactivation of the normal X (as judged by biochemical and cytogenetic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327725a0
更新日期:1987-06-25 00:00:00
abstract::Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35099674
更新日期:2001-10-18 00:00:00
abstract::Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13565
更新日期:2014-08-07 00:00:00
abstract::The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03845
更新日期:2005-08-11 00:00:00
abstract::Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/332228a0
更新日期:1988-03-17 00:00:00
abstract::Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive regions is not kno...
journal_title:Nature
pub_type: 临床试验,杂志文章
doi:10.1038/nature09510
更新日期:2010-10-28 00:00:00
abstract::Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1-4. H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2032-3
更新日期:2020-02-01 00:00:00
abstract::Intracellular signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2. MAP kinase activation is mediated by dual phosphorylation within the motif Thr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367651a0
更新日期:1994-02-17 00:00:00
abstract::Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11661
更新日期:2013-01-10 00:00:00
abstract::Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326662a0
更新日期:1987-04-16 00:00:00
abstract::Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07780
更新日期:2009-02-19 00:00:00
abstract::The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386066a0
更新日期:1997-03-06 00:00:00
abstract::What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361490a0
更新日期:1993-02-11 00:00:00
abstract::Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21379
更新日期:2017-03-09 00:00:00