Possible demographic consequences of AIDS in developing countries.

abstract：:Two principals in the once-raging debate over forensic DNA typing conclude that the scientific issues have all been resolved. ...

journal_title：Nature

authors： Lander ES,Budowle B

更新日期：1994-10-27 00:00:00

abstract：:Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...

journal_title：Nature

authors： Emorine L,Kuehl M,Weir L,Leder P,Max EE

更新日期：1983-08-04 00:00:00

abstract：:Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA ...

journal_title：Nature

authors： Murayama Y,Kurokawa Y,Mayanagi K,Iwasaki H

更新日期：2008-02-21 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtaine...

journal_title：Nature

authors： Tesar PJ,Chenoweth JG,Brook FA,Davies TJ,Evans EP,Mack DL,Gardner RL,McKay RD

更新日期：2007-07-12 00:00:00

abstract：:An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as well as the complete sequence analysis of 9 of these VH regions is presented. There seem to be more VH regions participating in the phosphorylch...

journal_title：Nature

authors： Gearhart PJ,Johnson ND,Douglas R,Hood L

更新日期：1981-05-07 00:00:00

abstract：:Fluctuations in the counting rate of photons originating from uncorrelated point sources become, within the coherently illuminated area, slightly enhanced compared to a random sequence of classical particles. This phenomenon, known in astronomy as the Hanbury Brown-Twiss effect, is a consequence of quantum interferenc...

journal_title：Nature

authors： Kiesel H,Renz A,Hasselbach F

更新日期：2002-07-25 00:00:00

abstract：:Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives of rubella viru...

journal_title：Nature

authors： Bennett AJ,Paskey AC,Ebinger A,Pfaff F,Priemer G,Höper D,Breithaupt A,Heuser E,Ulrich RG,Kuhn JH,Bishop-Lilly KA,Beer M,Goldberg TL

更新日期：2020-10-01 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...

journal_title：Nature

authors： Kim D,Lewis DL,Graziadei L,Neer EJ,Bar-Sagi D,Clapham DE

更新日期：1989-02-09 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:Amino-acid radicals play key roles in many enzymatic reactions. Catalysis often involves transfer of a radical character within the protein, as in class I ribonucleotide reductase where radical transfer occurs over 35 A, from a tyrosyl radical to a cysteine. It is currently debated whether this kind of long-range tran...

journal_title：Nature

authors： Aubert C,Vos MH,Mathis P,Eker AP,Brettel K

更新日期：2000-06-01 00:00:00

abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

journal_title：Nature

authors： Inoue I,Nagase H,Kishi K,Higuti T

更新日期：1991-07-18 00:00:00

abstract：:This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...

journal_title：Nature

authors： Silberberg D,Anand NP,Michels K,Kalaria RN

更新日期：2015-11-19 00:00:00

abstract：:The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases, which act as molecular switches in diverse signal-transduction processes. Various bacterial toxins can inactivate Rho GTPases by ADP-ribosylation or glucosylation. Previous research has identified Rho proteins as putative targets for Esc...

journal_title：Nature

authors： Schmidt G,Sehr P,Wilm M,Selzer J,Mann M,Aktories K

更新日期：1997-06-12 00:00:00

abstract：:Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and by the Voyager and Cassini spacecraft. The most puzzling aspects include the origin of the molecular nitrogen and methane in its atmosphere, and the mechanism(s) by which methane is maintained in the face of rapid destruct...

journal_title：Nature

authors： Niemann HB,Atreya SK,Bauer SJ,Carignan GR,Demick JE,Frost RL,Gautier D,Haberman JA,Harpold DN,Hunten DM,Israel G,Lunine JI,Kasprzak WT,Owen TC,Paulkovich M,Raulin F,Raaen E,Way SH

更新日期：2005-12-08 00:00:00

abstract：:Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...

journal_title：Nature

authors： Yean SL,Wuenschell G,Termini J,Lin RJ

更新日期：2000-12-14 00:00:00

abstract：:Retrospective epidemiological data have indicated that cutaneous malignant melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet radiation, particularly in children, rather than from the cumulative lifetime exposure that is associated with other forms of skin cancer. Here we ...

journal_title：Nature

authors： Noonan FP,Recio JA,Takayama H,Duray P,Anver MR,Rush WL,De Fabo EC,Merlino G

更新日期：2001-09-20 00:00:00

abstract：:Interleukin-2 (IL-2) has a key role in the antigen-specific clonal growth of T lymphocytes, by virtue of its interaction with a specific cell-surface receptor (IL-2R). The growth signal seems to be delivered by IL-2 bound to the high-affinity, but not the low-affinity, receptor. Genes encoding IL-2 and its receptor (t...

journal_title：Nature

authors： Hatakeyama M,Minamoto S,Uchiyama T,Hardy RR,Yamada G,Taniguchi T

更新日期：1985-12-05 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes. Variants at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can therefore be described as ...

journal_title：Nature

authors： Simmler MC,Rouyer F,Vergnaud G,Nyström-Lahti M,Ngo KY,de la Chapelle A,Weissenbach J

更新日期：1985-10-24 00:00:00

abstract：:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region,...

journal_title：Nature

authors： Foster J,Stafford J,Queen C

更新日期：1985-05-30 00:00:00

abstract：:Many homeobox genes are clustered in a linear array along a chromosome, reflecting their ordered expression along the anterior-posterior axis of the embryo. Expression patterns as well as grafting, ectopic expression and loss-of-function experiments suggest that the Hox genes encode a combinatorial system of positiona...

journal_title：Nature

authors： Roberts CW,Shutter JR,Korsmeyer SJ

更新日期：1994-04-21 00:00:00

abstract：:The promoters of eukaryotic genes are being increasingly defined through the identification of consensus DNA sequences, by mutational analysis, and by in vitro and in vivo studies of transcription. Whereas the TATA sequence (Goldberg-Hogness box) has been largely conserved among protein encoding genes (transcribed by ...

journal_title：Nature

authors： Russell PR

更新日期：1983-01-13 00:00:00

abstract：:In the prehistoric green Sahara of Holocene North Africa-in contrast to the Neolithic of Europe and Eurasia-a reliance on cattle, sheep and goats emerged as a stable and widespread way of life, long before the first evidence for domesticated plants or settled village farming communities. The remarkable rock art found ...

journal_title：Nature

authors： Dunne J,Evershed RP,Salque M,Cramp L,Bruni S,Ryan K,Biagetti S,di Lernia S

更新日期：2012-06-20 00:00:00

abstract：:In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided ...

journal_title：Nature

authors： Loppin B,Bonnefoy E,Anselme C,Laurençon A,Karr TL,Couble P

更新日期：2005-10-27 00:00:00

abstract：:Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...

journal_title：Nature

authors： Abbas YM,Pichlmair A,Górna MW,Superti-Furga G,Nagar B

更新日期：2013-02-07 00:00:00

abstract：:Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consuming pathways, and protects the heart against ischaemic injury and apoptosis. A role for circulating hormones such as adiponec...

journal_title：Nature

authors： Miller EJ,Li J,Leng L,McDonald C,Atsumi T,Bucala R,Young LH

更新日期：2008-01-31 00:00:00

abstract：:Cosmid, yeast artificial chromosome (YAC), P1 and complementary DNA (cDNA) libraries are distributed on high-density filters to the scientific community and experimental results are stored in a common object-based database accessible through the Internet. ...

journal_title：Nature

authors： Zehetner G,Lehrach H

更新日期：1994-02-03 00:00:00