Hox11 controls the genesis of the spleen.

abstract：:Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...

journal_title：Nature

authors： Rawat UB,Zavialov AV,Sengupta J,Valle M,Grassucci RA,Linde J,Vestergaard B,Ehrenberg M,Frank J

更新日期：2003-01-02 00:00:00

abstract：:Guanine-nucleotide exchange factors on ADP-ribosylation factor GTPases (ARF-GEFs) regulate vesicle formation in time and space by activating ARF substrates on distinct donor membranes. Mammalian GBF1 (ref. 2) and yeast Gea1/2 (ref. 3) ARF-GEFs act at Golgi membranes, regulating COPI-coated vesicle formation. In contra...

journal_title：Nature

authors： Richter S,Geldner N,Schrader J,Wolters H,Stierhof YD,Rios G,Koncz C,Robinson DG,Jürgens G

更新日期：2007-07-26 00:00:00

abstract：: ...

journal_title：Nature

authors： Payne D

更新日期：2018-11-01 00:00:00

abstract：:Distrust in scientific expertise1-14 is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks2-4, as happened for measles in 20195,6. Homemade remedies7,8 and falsehoods are being shared widely on the Internet, as well as dismi...

journal_title：Nature

authors： Johnson NF,Velásquez N,Restrepo NJ,Leahy R,Gabriel N,El Oud S,Zheng M,Manrique P,Wuchty S,Lupu Y

更新日期：2020-06-01 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and Rab-GTPases, together with their cofactors, mediate the attachment step in the membrane fusion of vesicles. But how bilayer mixing--the subsequent core process of fusion--is catalysed remains unclear. Ca2+/calmodulin controls this term...

journal_title：Nature

authors： Peters C,Bayer MJ,Bühler S,Andersen JS,Mann M,Mayer A

更新日期：2001-02-01 00:00:00

abstract：:Understanding the relative timings of climate events in the Northern and Southern hemispheres is a prerequisite for determining the causes of abrupt climate changes. But climate records from the Patagonian Andes and New Zealand for the period of transition from glacial to interglacial conditions--about 14.6-10 kyr bef...

journal_title：Nature

authors： Moreno PI,Jacobson GL Jr,Lowell TV,Denton GH

更新日期：2001-02-15 00:00:00

abstract：:Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and mor...

journal_title：Nature

authors： Ries G,Heller W,Puchta H,Sandermann H,Seidlitz HK,Hohn B

更新日期：2000-07-06 00:00:00

abstract：:Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...

journal_title：Nature

authors： Kennedy JL,Giuffra LA,Moises HW,Cavalli-Sforza LL,Pakstis AJ,Kidd JR,Castiglione CM,Sjogren B,Wetterberg L,Kidd KK

更新日期：1988-11-10 00:00:00

abstract：:The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...

journal_title：Nature

authors： Belich MP,Salmerón A,Johnston LH,Ley SC

更新日期：1999-01-28 00:00:00

abstract：:GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is both stabilized by GAP binding and complemented by the insertion of...

journal_title：Nature

authors： Seewald MJ,Körner C,Wittinghofer A,Vetter IR

更新日期：2002-02-07 00:00:00

abstract：:Hydrothermal vents are ephemeral because of frequent volcanic and tectonic activities associated with crust formation. Although the larvae of hydrothermal vent fauna can rapidly colonize new vent sites separated by tens to hundreds of kilometres, the mechanisms by which these larvae disperse and recruit are not unders...

journal_title：Nature

authors： Marsh AG,Mullineaux LS,Young CM,Manahan DT

更新日期：2001-05-03 00:00:00

abstract：:Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies. Efforts to target this oncogene directly have faced difficulties owing to its picomolar affinity for GTP/GDP and the absence of known alloster...

journal_title：Nature

authors： Ostrem JM,Peters U,Sos ML,Wells JA,Shokat KM

更新日期：2013-11-28 00:00:00

abstract：:Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown. Here we systematically explore interactions between the nucleosome and 220 tr...

journal_title：Nature

authors： Zhu F,Farnung L,Kaasinen E,Sahu B,Yin Y,Wei B,Dodonova SO,Nitta KR,Morgunova E,Taipale M,Cramer P,Taipale J

更新日期：2018-10-01 00:00:00

abstract：:Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antib...

journal_title：Nature

authors： Takai T,Ono M,Hikida M,Ohmori H,Ravetch JV

更新日期：1996-01-25 00:00:00

abstract：:Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

journal_title：Nature

authors： Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

更新日期：2007-06-21 00:00:00

abstract：:Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest. The Malaria Genomic Epidemiology Network (MalariaGEN) is now working to overcome ...

journal_title：Nature

authors： Malaria Genomic Epidemiology Network.

更新日期：2008-12-11 00:00:00

abstract：:Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...

journal_title：Nature

authors： Goud B,Zahraoui A,Tavitian A,Saraste J

更新日期：1990-06-07 00:00:00

abstract：:Materials are said to show a shape-memory effect if they can be deformed and fixed into a temporary shape, and recover their original, permanent shape only on exposure to an external stimulus. Shape-memory polymers have received increasing attention because of their scientific and technological significance. In princi...

journal_title：Nature

authors： Lendlein A,Jiang H,Jünger O,Langer R

更新日期：2005-04-14 00:00:00

abstract：:Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...

journal_title：Nature

authors： Cox JS,Chen B,McNeil M,Jacobs WR Jr

更新日期：1999-11-04 00:00:00

abstract：:Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services. Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels. However, only a few studies have so far incorporated an explic...

journal_title：Nature

authors： Scherber C,Eisenhauer N,Weisser WW,Schmid B,Voigt W,Fischer M,Schulze ED,Roscher C,Weigelt A,Allan E,Bessler H,Bonkowski M,Buchmann N,Buscot F,Clement LW,Ebeling A,Engels C,Halle S,Kertscher I,Klein AM,Koller R,

更新日期：2010-11-25 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...

journal_title：Nature

authors： Ganeshram RS,Pedersen TF,Calvert S,François R

更新日期：2002-01-10 00:00:00

abstract：:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...

journal_title：Nature

authors： Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson L

更新日期：1992-02-27 00:00:00

abstract：:Indirect reciprocity is a key mechanism for the evolution of human cooperation. Our behaviour towards other people depends not only on what they have done to us but also on what they have done to others. Indirect reciprocity works through reputation. The standard model of indirect reciprocity offers a binary choice: p...

journal_title：Nature

authors： Ohtsuki H,Iwasa Y,Nowak MA

更新日期：2009-01-01 00:00:00

abstract：:The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...

journal_title：Nature

authors： Liu F,Hata A,Baker JC,Doody J,Cárcamo J,Harland RM,Massagué J

更新日期：1996-06-13 00:00:00

abstract：:During wild-type development, a protein product of the Caenorhabditis elegans heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early larvae, but is absent in late larvae and adult soma. Gain-of-function lin-14 mutations cause the level of lin-14 protein to remain high throughou...

journal_title：Nature

authors： Ruvkun G,Giusto J

更新日期：1989-03-23 00:00:00

abstract：:It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...

journal_title：Nature

authors： Toyoshima YY,Toyoshima C,Spudich JA

更新日期：1989-09-14 00:00:00

abstract：:The medial entorhinal cortex (MEC) is part of the brain's circuit for dynamic representation of self-location. The metric of this representation is provided by grid cells, cells with spatial firing fields that tile environments in a periodic hexagonal pattern. Limited anatomical sampling has obscured whether the grid ...

journal_title：Nature

authors： Stensola H,Stensola T,Solstad T,Frøland K,Moser MB,Moser EI

更新日期：2012-12-06 00:00:00

abstract：:Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...

journal_title：Nature

authors： Shepherd A,Fricker HA,Farrell SL

更新日期：2018-06-01 00:00:00