Abstract：
:Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and morphological responses characterized as acclimation and adaptation. Here we show, using special sun simulators, that elevated solar UV-B doses increase the frequency of somatic homologous DNA rearrangements in Arabidopsis and tobacco plants. Increases in recombination are accompanied by a strong induction of photolyase and Rad51 gene expression. These genes are putatively involved in major DNA repair pathways, photoreactivation and recombination repair. In mutant Arabidopsis plants that are deficient in photoreactivating ultraviolet-induced cyclobutane pyrimidine dimers, recombination under elevated UV-B regimes greatly exceeds wild-type levels. Our results show that homologous recombination repair pathways might be involved in eliminating UV-B-induced DNA lesions in plants. Thus, increases in terrestrial solar UV-B radiation as forecasted for the early 21st century may affect genome stability in plants.
journal_name
Naturejournal_title
Natureauthors
Ries G,Heller W,Puchta H,Sandermann H,Seidlitz HK,Hohn Bdoi
10.1038/35017595keywords:
subject
Has Abstractpub_date
2000-07-06 00:00:00pages
98-101issue
6791eissn
0028-0836issn
1476-4687journal_volume
406pub_type
杂志文章相关文献
NATURE文献大全abstract：:There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and reduce the number and severity of adverse drug reactions. However, such personalization of drug treatments requires the ability to predict how different individuals will ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04648
更新日期：2006-04-20 00:00:00
abstract：:The T-cell specific, rearranging gamma-chain genes bear striking resemblance to T-cell receptor and immunoglobulin genes, but the role of gamma remains unknown. A central problem is to understand the conditions under which gamma RNA is expressed in cells. The transcription of gamma is abundant in T cells of fetal thym...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/323635a0
更新日期：1986-10-16 00:00:00
abstract：:Subcutaneous (s.c.) administration of Arg-vasopressin (AVP) prolongs retention of a learned behaviour and elevates arterial blood pressure. Intracerebroventricular (i.c.v.) injection of a thousandfold lower dose of AVP than needed with s.c. injection produces the same behavioural effect, suggesting that AVP acts on th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/301608a0
更新日期：1983-02-17 00:00:00
abstract：:Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11661
更新日期：2013-01-10 00:00:00
abstract：:At the molecular level, muscle contraction is the result of cyclic interaction between myosin crossbridges, which extend from the thick filament, and the thin filament, which consists mainly of actin. The energy for work done by a single crossbridge during a cycle of attachment, generation of force, shortening and det...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/355638a0
更新日期：1992-02-13 00:00:00
abstract：:Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35021239
更新日期：2000-08-17 00:00:00
abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/288088a0
更新日期：1980-11-06 00:00:00
abstract：:A consequence of relativity is that in the presence of an electric field, the spin and momentum states of an electron can be coupled; this is known as spin-orbit coupling. Such an interaction opens a pathway to the manipulation of electron spins within non-magnetic semiconductors, in the absence of applied magnetic fi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02202
更新日期：2004-01-01 00:00:00
abstract：:Spontaneous type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. This causes an inability to regulate glucose metabolism, which results in dangerously raised blood glucose concentrations. It is generally accepted that thymus-derived lymphocyt...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature04423
更新日期：2005-11-24 00:00:00
abstract：:Genomes from all of the crucial bacterial pathogens of humans, plants and animals have now been sequenced, as have genomes from many of the important commensal, symbiotic and environmental microorganisms. Analysis of these sequences has revealed the forces that shape pathogen evolution and has brought to light unexpec...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature06248
更新日期：2007-10-18 00:00:00
abstract：:Nitrogen enrichment is widely thought to be responsible for the loss of plant species from temperate terrestrial ecosystems. This view is based on field surveys and controlled experiments showing that species richness correlates negatively with high productivity and nitrogen enrichment. However, as the type of nutrien...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03950
更新日期：2005-09-22 00:00:00
abstract：:In 1928, Dirac published an equation 1 that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles-antimatter. The existence of particles of antimatter was conf...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0017-2
更新日期：2018-05-01 00:00:00
abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10661
更新日期：2011-12-14 00:00:00
abstract：:Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, howev...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04882
更新日期：2006-07-20 00:00:00
abstract：:The intracellular free Ca2+ ([Ca2+]i) regulates the K+ conductance (GK) of the many types of cell membrane. The Ca2+ influx during an action potential activates this [Ca2+]i-linked GK in most neurones. In caffeine-treated sympathetic ganglion cells, however, Ca2+ released from an intracellular Ca2+ reservoir site anal...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/283204a0
更新日期：1980-01-10 00:00:00
abstract：:Oxygen and silicon isotope compositions of cherts and studies of protein evolution have been interpreted to reflect ocean temperatures of 55-85 degrees C during the early Palaeoarchaean era ( approximately 3.5 billion years ago). A recent study combining oxygen and hydrogen isotope compositions of cherts, however, mak...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature08952
更新日期：2010-04-15 00:00:00
abstract：:Relative to the present day, meridional temperature gradients in the Early Eocene age ( approximately 56-53 Myr ago) were unusually low, with slightly warmer equatorial regions but with much warmer subtropical Arctic and mid-latitude climates. By the end of the Eocene epoch ( approximately 34 Myr ago), the first major...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature08399
更新日期：2009-10-08 00:00:00
abstract：:A key event in the domestication and breeding of the oil palm Elaeis guineensis was loss of the thick coconut-like shell surrounding the kernel. Modern E. guineensis has three fruit forms, dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), a hybrid between dura and pisifera. The pisifera palm is us...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12356
更新日期：2013-08-15 00:00:00
abstract：:Memory formation is a multi-stage process that initially requires cellular consolidation in the hippocampus, after which memories are downloaded to the cortex for maintenance, in a process termed systems consolidation. Epigenetic mechanisms regulate both types of consolidation, but histone variant exchange, in which c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13707
更新日期：2014-11-27 00:00:00
abstract：:Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggest...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/363083a0
更新日期：1993-05-06 00:00:00
abstract：:RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/364550a0
更新日期：1993-08-05 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/d41586-019-00676-y
更新日期：2019-02-01 00:00:00
abstract：:Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C). PrP(Sc) is thought to replicate by imparting its conformation onto PrP(C) (ref. 1), yet conformational discrimination between PrP(C) and PrP(Sc) has remained elusive. Because depositi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35044100
更新日期：2000-11-23 00:00:00
abstract：:A wide range of receptors are located at the blood sinusoidal aspect of the hepatocyte plasma membrane. Many circulating ligands that bind to receptors on the cell surfaces are interiorized along two pathways. Asialoglycoproteins are transferred from the plasma membrane to lysosomes and degraded, whereas immunoglobuli...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/298398a0
更新日期：1982-07-22 00:00:00
abstract：:Recognition of objects or environmental landmarks is problematic because appearance can vary widely depending on illumination, viewing distance, angle of view and so on. Storing a separate image or 'template' for every possible view requires vast numbers to be stored and scanned, has a high probability of recognition ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35001064
更新日期：2000-02-10 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/370341a0
更新日期：1994-08-04 00:00:00
abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01678
更新日期：2003-05-29 00:00:00
abstract：:The formation of glasses is normal for substances that remain liquid over a wide temperature range (the 'good glassformers') and can be induced for most liquids if cooling is fast enough to bypass crystallization. During reheating but still below the melting point, good glassformers exhibit glass transitions as they a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02295
更新日期：2004-02-19 00:00:00
abstract：:The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/36038
更新日期：1998-02-26 00:00:00
abstract：:Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/26261
更新日期：1998-09-17 00:00:00
