Field sports and conservation in the United Kingdom.

abstract：:The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...

journal_title：Nature

authors： Alushin GM,Ramey VH,Pasqualato S,Ball DA,Grigorieff N,Musacchio A,Nogales E

更新日期：2010-10-14 00:00:00

abstract：:Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic ti...

journal_title：Nature

authors： Wheat JC,Sella Y,Willcockson M,Skoultchi AI,Bergman A,Singer RH,Steidl U

更新日期：2020-07-01 00:00:00

abstract：:We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, reveali...

journal_title：Nature

authors： Keane TM,Goodstadt L,Danecek P,White MA,Wong K,Yalcin B,Heger A,Agam A,Slater G,Goodson M,Furlotte NA,Eskin E,Nellåker C,Whitley H,Cleak J,Janowitz D,Hernandez-Pliego P,Edwards A,Belgard TG,Oliver PL,McIntyre RE,

更新日期：2011-09-14 00:00:00

abstract：:Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4(CRBN) E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubi...

journal_title：Nature

authors： Matyskiela ME,Lu G,Ito T,Pagarigan B,Lu CC,Miller K,Fang W,Wang NY,Nguyen D,Houston J,Carmel G,Tran T,Riley M,Nosaka L,Lander GC,Gaidarova S,Xu S,Ruchelman AL,Handa H,Carmichael J,Daniel TO,Cathers BE,Lopez-Gi

更新日期：2016-07-14 00:00:00

abstract：:Dusty disks around young stars are formed out of interstellar dust that consists of amorphous, submicrometre grains. Yet the grains found in comets and meteorites, and traced in the spectra of young stars, include large crystalline grains that must have undergone annealing or condensation at temperatures in excess of ...

journal_title：Nature

authors： Vinković D

更新日期：2009-05-14 00:00:00

abstract：:The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modificati...

journal_title：Nature

authors： Pershadsingh HA,McDonald JM

更新日期：1979-10-11 00:00:00

abstract：:Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...

journal_title：Nature

authors： Lo I,Denef VJ,Verberkmoes NC,Shah MB,Goltsman D,DiBartolo G,Tyson GW,Allen EE,Ram RJ,Detter JC,Richardson P,Thelen MP,Hettich RL,Banfield JF

更新日期：2007-03-29 00:00:00

abstract：:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...

journal_title：Nature

authors： Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson L

更新日期：1992-02-27 00:00:00

abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

journal_title：Nature

authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

更新日期：2020-03-01 00:00:00

abstract：:The Gulf Stream transports approximately 31 Sv (1 Sv = 10(6) m(3) s(-1)) of water and 1.3 x 10(15) W of heat into the North Atlantic ocean. The possibility of abrupt changes in Gulf Stream heat transport is one of the key uncertainties in predictions of climate change for the coming centuries. Given the limited length...

journal_title：Nature

authors： Lund DC,Lynch-Stieglitz J,Curry WB

更新日期：2006-11-30 00:00:00

abstract：:In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent neurotrophic factor for dopamine neurons described so far is the glial...

journal_title：Nature

authors： Lindholm P,Voutilainen MH,Laurén J,Peränen J,Leppänen VM,Andressoo JO,Lindahl M,Janhunen S,Kalkkinen N,Timmusk T,Tuominen RK,Saarma M

更新日期：2007-07-05 00:00:00

abstract：:Conjugate (or 1,4-) additions of carbanionic species to α,β-unsaturated carbonyl compounds are vital to research in organic and medicinal chemistry, and there are several chiral catalysts that facilitate the catalytic enantioselective additions of nucleophiles to enoates. Nonetheless, catalytic enantioselective 1,6-co...

journal_title：Nature

authors： Meng F,Li X,Torker S,Shi Y,Shen X,Hoveyda AH

更新日期：2016-09-15 00:00:00

abstract：:The 37-amino-acid calcitonin gene-related peptide (CGRP) occurs as a result of alternative processing of mRNA from the calcitonin gene. The potency of CGRP as a vasodilator and the occurrence of the peptide in nerves associated with blood vessels suggest an important role for CGRP in the regulation of blood flow. The ...

journal_title：Nature

authors： Brain SD,Williams TJ

更新日期：1988-09-01 00:00:00

abstract：:Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...

journal_title：Nature

authors： Zhang Z,Zhang Y,Xia S,Kong Q,Li S,Liu X,Junqueira C,Meza-Sosa KF,Mok TMY,Ansara J,Sengupta S,Yao Y,Wu H,Lieberman J

更新日期：2020-03-01 00:00:00

abstract：:Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking o...

journal_title：Nature

authors： Bannister AJ,Kouzarides T

更新日期：2005-08-25 00:00:00

abstract：:Felsenstein's application of the bootstrap method to evolutionary trees is one of the most cited scientific papers of all time. The bootstrap method, which is based on resampling and replications, is used extensively to assess the robustness of phylogenetic inferences. However, increasing numbers of sequences are now ...

journal_title：Nature

authors： Lemoine F,Domelevo Entfellner JB,Wilkinson E,Correia D,Dávila Felipe M,De Oliveira T,Gascuel O

更新日期：2018-04-01 00:00:00

abstract：:The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathway is transduced by two receptor families. Frizzled proteins and lipoprotein-receptor-related proteins 5 and 6 (LRP5/6) bin...

journal_title：Nature

authors： Mao B,Wu W,Davidson G,Marhold J,Li M,Mechler BM,Delius H,Hoppe D,Stannek P,Walter C,Glinka A,Niehrs C

更新日期：2002-06-06 00:00:00

abstract：:Self-replication has been demonstrated in synthetic chemical systems based on oligonucleotides, peptides and complementary molecules without natural analogues. However, within a living cell virtually no molecule catalyses its own formation, and the search for chemical systems in which both auto- and cross-catalysis ca...

journal_title：Nature

authors： Yao S,Ghosh I,Zutshi R,Chmielewski J

更新日期：1998-12-03 00:00:00

abstract：:A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...

journal_title：Nature

authors： Beroukhim R,Mermel CH,Porter D,Wei G,Raychaudhuri S,Donovan J,Barretina J,Boehm JS,Dobson J,Urashima M,Mc Henry KT,Pinchback RM,Ligon AH,Cho YJ,Haery L,Greulich H,Reich M,Winckler W,Lawrence MS,Weir BA,Tanaka KE,

更新日期：2010-02-18 00:00:00

abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...

journal_title：Nature

authors： Cheour M,Martynova O,Näätänen R,Erkkola R,Sillanpää M,Kero P,Raz A,Kaipio ML,Hiltunen J,Aaltonen O,Savela J,Hämäläinen H

更新日期：2002-02-07 00:00:00

abstract：:Angiosperms developed floral nectaries that reward pollinating insects. Although nectar function and composition have been characterized, the mechanism of nectar secretion has remained unclear. Here we identify SWEET9 as a nectary-specific sugar transporter in three eudicot species: Arabidopsis thaliana, Brassica rapa...

journal_title：Nature

authors： Lin IW,Sosso D,Chen LQ,Gase K,Kim SG,Kessler D,Klinkenberg PM,Gorder MK,Hou BH,Qu XQ,Carter CJ,Baldwin IT,Frommer WB

更新日期：2014-04-24 00:00:00

abstract：:The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...

journal_title：Nature

authors： Green R,Ellington AD,Szostak JW

更新日期：1990-09-27 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

journal_title：Nature

authors： Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

更新日期：1997-09-04 00:00:00

abstract：:Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecu...

journal_title：Nature

authors： Carmona-Fontaine C,Matthews HK,Kuriyama S,Moreno M,Dunn GA,Parsons M,Stern CD,Mayor R

更新日期：2008-12-18 00:00:00

abstract：:Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...

journal_title：Nature

authors： Goud B,Zahraoui A,Tavitian A,Saraste J

更新日期：1990-06-07 00:00:00

abstract：:Large parts of the Antarctic ice sheet lying on bedrock below sea level may be vulnerable to marine-ice-sheet instability (MISI), a self-sustaining retreat of the grounding line triggered by oceanic or atmospheric changes. There is growing evidence that MISI may be underway throughout the Amundsen Sea embayment (ASE),...

journal_title：Nature

authors： Ritz C,Edwards TL,Durand G,Payne AJ,Peyaud V,Hindmarsh RC

更新日期：2015-12-03 00:00:00

abstract：:The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...

journal_title：Nature

authors： Liu M,Simon MI

更新日期：1996-07-04 00:00:00

abstract：:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...

journal_title：Nature

authors： Primakoff P,Lathrop W,Woolman L,Cowan A,Myles D

更新日期：1988-10-06 00:00:00

abstract：:Fixed nitrogen (N) often limits the growth of organisms in terrestrial and aquatic biomes, and N availability has been important in controlling the CO2 balance of modern and ancient oceans. The fixation of atmospheric dinitrogen gas (N2) to ammonia is catalysed by nitrogenase and provides a fixed N for N-limited envir...

journal_title：Nature

authors： Zehr JP,Waterbury JB,Turner PJ,Montoya JP,Omoregie E,Steward GF,Hansen A,Karl DM

更新日期：2001-08-09 00:00:00

abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

journal_title：Nature

authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

更新日期：2019-01-01 00:00:00