Abstract:
:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm proteins might be useful in the development of a contraceptive vaccine. The guinea pig sperm surface protein PH-20 is essential in sperm adhesion to the extracellular coat (zona pellucida) of the egg, a necessary initial step in fertilization. Here, we report that 100% effective contraception was obtained in male and female guinea pigs immunized with PH-20. Antisera from immunized females had high titres, specifically recognized PH-20 in sperm extracts, and blocked sperm adhesion to the egg zona pellucida in vitro. The contraceptive effect was long-lasting and reversible: immunized females, mated at intervals of six to fifteen months after immunization, progressively regained fertility.
journal_name
Naturejournal_title
Natureauthors
Primakoff P,Lathrop W,Woolman L,Cowan A,Myles Ddoi
10.1038/335543a0subject
Has Abstractpub_date
1988-10-06 00:00:00pages
543-6issue
6190eissn
0028-0836issn
1476-4687journal_volume
335pub_type
杂志文章相关文献
NATURE文献大全abstract::Over the past 50 years there has been much speculation about the energetic cost of swimming and wave-riding by dolphins. When aligned properly in front of the bow of moving ships in the stern wake of small boats, on wind waves, and even in the wake of larger cetaceans, the animals appear to move effortlessly through t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355821a0
更新日期:1992-02-27 00:00:00
abstract::One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35011062
更新日期:2000-05-04 00:00:00
abstract::A report adopted by the Council of Europe lists eight recommendations on the legal, ethical, and social issues raised by recombinant DNA research. The legislators stressed that the right to a "genetic inheritance free from any form of engineering" should be included in the European Human Rights Convention, and that s...
journal_title:Nature
pub_type: 新闻
doi:10.1038/295545a0
更新日期:1982-02-18 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07853-5
更新日期:2019-01-01 00:00:00
abstract::Mechanical stimuli can modify the energy landscape of chemical reactions and enable reaction pathways, offering a synthetic strategy that complements conventional chemistry. These mechanochemical mechanisms have been studied extensively in one-dimensional polymers under tensile stress using ring-opening and reorganiza...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25765
更新日期:2018-02-21 00:00:00
abstract::The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335090a0
更新日期:1988-09-01 00:00:00
abstract::Erythropoietin is the primary physiological regulator of erythropoiesis; however, in vitro studies have identified another class of mediators which appear to be important in stimulating erythroid progenitors. These factors have generally been referred to as burst-promoting activities (BPA), because they stimulate the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315768a0
更新日期:1985-06-27 00:00:00
abstract::The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse applications in quantum computing and communications1. However, fluorescent nanodiamonds also have attractive properties for in vitro biosensing, including brightness2, low cost3 and selective manipulation of their emission4. Nanoparticl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2917-1
更新日期:2020-11-01 00:00:00
abstract::The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/366654a0
更新日期:1993-12-16 00:00:00
abstract::The crystal structure of the diphtheria toxin dimer at 2.5 A resolution reveals a Y-shaped molecule of three domains. The catalytic domain, called fragment A, is of the alpha + beta type. Fragment B actually consists of two domains. The transmembrane domain consists of nine alpha-helices, two pairs of which are unusua...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/357216a0
更新日期:1992-05-21 00:00:00
abstract::The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates bo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11000
更新日期:2012-05-03 00:00:00
abstract::Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386827a0
更新日期:1997-04-24 00:00:00
abstract::Rapidly growing cells produce thousands of new ribosomes each minute, in a tightly regulated process that is essential to cell growth. How the Escherichia coli 16S ribosomal RNA and the 20 proteins that make up the 30S ribosomal subunit can assemble correctly in a few minutes remains a challenging problem, partly beca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07298
更新日期:2008-10-30 00:00:00
abstract::It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature18846
更新日期:2016-07-07 00:00:00
abstract::Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion anal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature751
更新日期:2002-05-30 00:00:00
abstract::Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metaz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08140
更新日期:2009-07-16 00:00:00
abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08005
更新日期:2009-05-28 00:00:00
abstract::The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35097083
更新日期:2001-10-04 00:00:00
abstract::The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326886a0
更新日期:1987-04-30 00:00:00
abstract::The erosion of mountain belts controls their topographic and structural evolution and is the main source of sediment delivered to the oceans. Mountain erosion rates have been estimated from current relief and precipitation, but a more complete evaluation of the controls on erosion rates requires detailed measurements ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02150
更新日期:2003-12-11 00:00:00
abstract::Atrial extracts contain factors which induce potent natriuresis changes in renal haemodynamics, and relax pre-contracted vascular smooth muscle. Low-molecular-weight peptides which mimic these actions have now been purified by several groups, including ours (see accompanying paper), and higher-molecular-weight protein...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309719a0
更新日期:1984-06-21 00:00:00
abstract::To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13574
更新日期:2014-07-31 00:00:00
abstract::DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13923
更新日期:2015-02-12 00:00:00
abstract::Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), a much milder form of the disease where the age of onset can sometimes be as late as the third or fourth decade of life, are caused by mutations in the same X-linked gene, a 14 kilobase (kb) transcript which is spread over more than 2 megabases of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343180a0
更新日期:1990-01-11 00:00:00
abstract::Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10143
更新日期:2011-05-25 00:00:00
abstract::Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell membranes. This macromolecular machine resembles a stretched, coiled spring (or sheath) wound around a rigid tube with a spike-shaped pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17971
更新日期:2016-05-19 00:00:00
abstract::In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting it...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332509a0
更新日期:1988-04-07 00:00:00
abstract::It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313678a0
更新日期:1985-02-21 00:00:00
abstract::Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2929-x
更新日期:2020-11-01 00:00:00
abstract::Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13374
更新日期:2014-07-17 00:00:00