Radiation-pressure mixing of large dust grains in protoplanetary disks.

abstract：:In Xenopus the c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the progression from meiosis I to meiosis II and for the second meiotic metaphase arrest, acting as an essential component of the cytostatic factor CSF. Its function in mouse oocytes is unclear, however, as is t...

journal_title：Nature

authors： Hashimoto N,Watanabe N,Furuta Y,Tamemoto H,Sagata N,Yokoyama M,Okazaki K,Nagayoshi M,Takeda N,Ikawa Y

更新日期：1994-07-07 00:00:00

abstract：:5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...

journal_title：Nature

authors： Lummis SC,Beene DL,Lee LW,Lester HA,Broadhurst RW,Dougherty DA

更新日期：2005-11-10 00:00:00

abstract：:Transposable elements of DNA that are structurally defined and genetically discrete units seem to have an important role in the evolution of bacterial plasmids. Recombination occurring at the termini of such elements can result in the joining together of unrelated DNA segments that lack extensive nucleotide sequence h...

journal_title：Nature

authors： Cohen SN

更新日期：1976-10-28 00:00:00

abstract：:Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption1. Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers1,2. Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which whe...

journal_title：Nature

authors： Hodskinson MR,Bolner A,Sato K,Kamimae-Lanning AN,Rooijers K,Witte M,Mahesh M,Silhan J,Petek M,Williams DM,Kind J,Chin JW,Patel KJ,Knipscheer P

更新日期：2020-03-01 00:00:00

abstract：:Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...

journal_title：Nature

authors： Asangani IA,Dommeti VL,Wang X,Malik R,Cieslik M,Yang R,Escara-Wilke J,Wilder-Romans K,Dhanireddy S,Engelke C,Iyer MK,Jing X,Wu YM,Cao X,Qin ZS,Wang S,Feng FY,Chinnaiyan AM

更新日期：2014-06-12 00:00:00

abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

journal_title：Nature

authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

更新日期：1995-10-12 00:00:00

abstract：:The emergence of HIV-1 group M subtype B in North American men who have sex with men was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US) throughout the 1970s and an even older presence in the Caribbean. However, these temporal an...

journal_title：Nature

authors： Worobey M,Watts TD,McKay RA,Suchard MA,Granade T,Teuwen DE,Koblin BA,Heneine W,Lemey P,Jaffe HW

更新日期：2016-11-03 00:00:00

abstract：:Pinocytosis and membrane ruffling are among the earliest and most dramatic cellular responses to stimulation by growth factors or other mitogens. The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xe...

journal_title：Nature

authors： Lamaze C,Chuang TH,Terlecky LJ,Bokoch GM,Schmid SL

更新日期：1996-07-11 00:00:00

abstract：:Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...

journal_title：Nature

authors： Pepys MB,Hirschfield GM,Tennent GA,Gallimore JR,Kahan MC,Bellotti V,Hawkins PN,Myers RM,Smith MD,Polara A,Cobb AJ,Ley SV,Aquilina JA,Robinson CV,Sharif I,Gray GA,Sabin CA,Jenvey MC,Kolstoe SE,Thompson D,Wood SP

更新日期：2006-04-27 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...

journal_title：Nature

authors： Ruan Z,Osei-Owusu J,Du J,Qiu Z,Lü W

更新日期：2020-12-01 00:00:00

abstract：:Protonic ceramic fuel cells, like their higher-temperature solid-oxide fuel cell counterparts, can directly use both hydrogen and hydrocarbon fuels to produce electricity at potentially more than 50 per cent efficiency1,2. Most previous direct-hydrocarbon fuel cell research has focused on solid-oxide fuel cells based ...

journal_title：Nature

authors： Duan C,Kee RJ,Zhu H,Karakaya C,Chen Y,Ricote S,Jarry A,Crumlin EJ,Hook D,Braun R,Sullivan NP,O'Hayre R

更新日期：2018-05-01 00:00:00

abstract：:The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...

journal_title：Nature

authors： Postberg F,Schmidt J,Hillier J,Kempf S,Srama R

更新日期：2011-06-22 00:00:00

abstract：:Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent s...

journal_title：Nature

authors： Yeung N,Lin YW,Gao YG,Zhao X,Russell BS,Lei L,Miner KD,Robinson H,Lu Y

更新日期：2009-12-24 00:00:00

abstract：:Increasing human populations around the global coastline have caused extensive loss, degradation and fragmentation of coastal ecosystems, threatening the delivery of important ecosystem services1. As a result, alarming losses of mangrove, coral reef, seagrass, kelp forest and coastal marsh ecosystems have occurred1-6....

journal_title：Nature

authors： Murray NJ,Phinn SR,DeWitt M,Ferrari R,Johnston R,Lyons MB,Clinton N,Thau D,Fuller RA

更新日期：2019-01-01 00:00:00

abstract：:The dehydration of subducting oceanic crust and upper mantle has been inferred both to promote the partial melting leading to arc magmatism and to induce intraslab intermediate-depth earthquakes, at depths of 50-300 km. Yet there is still no consensus about how slab hydration occurs or where and how much chemically bo...

journal_title：Nature

authors： Ranero CR,Morgan JP,McIntosh K,Reichert C

更新日期：2003-09-25 00:00:00

abstract：:Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. At...

journal_title：Nature

authors： Almeida J,Schobesberger S,Kürten A,Ortega IK,Kupiainen-Määttä O,Praplan AP,Adamov A,Amorim A,Bianchi F,Breitenlechner M,David A,Dommen J,Donahue NM,Downard A,Dunne E,Duplissy J,Ehrhart S,Flagan RC,Franchin A,Guida R

更新日期：2013-10-17 00:00:00

abstract：:The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...

journal_title：Nature

authors： Ooi YM,Ooi BS

更新日期：1982-07-22 00:00:00

abstract：:Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...

journal_title：Nature

authors： Kretz M,Siprashvili Z,Chu C,Webster DE,Zehnder A,Qu K,Lee CS,Flockhart RJ,Groff AF,Chow J,Johnston D,Kim GE,Spitale RC,Flynn RA,Zheng GX,Aiyer S,Raj A,Rinn JL,Chang HY,Khavari PA

更新日期：2013-01-10 00:00:00

abstract：:Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic g...

journal_title：Nature

authors： Tang XD,Xu R,Reynolds MF,Garcia ML,Heinemann SH,Hoshi T

更新日期：2003-10-02 00:00:00

abstract：:With only a few exceptions that are well understood, conventional superconductivity does not coexist with long-range magnetic order (for example, ref. 1). Unconventional superconductivity, on the other hand, develops near a phase boundary separating magnetically ordered and magnetically disordered phases. A maximum in...

journal_title：Nature

authors： Park T,Ronning F,Yuan HQ,Salamon MB,Movshovich R,Sarrao JL,Thompson JD

更新日期：2006-03-02 00:00:00

abstract：:Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the co...

journal_title：Nature

authors： Gandon S,Mackinnon MJ,Nee S,Read AF

更新日期：2001-12-13 00:00:00

abstract：:Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...

journal_title：Nature

authors： Necsulea A,Soumillon M,Warnefors M,Liechti A,Daish T,Zeller U,Baker JC,Grützner F,Kaessmann H

更新日期：2014-01-30 00:00:00

abstract：:Vertical movement of the hip during locomotion causes a loaded backpack to be accelerated with each step, which imposes large peak forces on the wearer. Here we show that using bungee cords to suspend the load from a backpack frame reduces not only its vertical movement, and hence its vertical force on the carrier, bu...

journal_title：Nature

authors： Rome LC,Flynn L,Yoo TD

更新日期：2006-12-21 00:00:00

abstract：:Many galaxies are thought to have supermassive black holes at their centres-more than a million times the mass of the Sun. Measurements of stellar velocities and the discovery of variable X-ray emission have provided strong evidence in favour of such a black hole at the centre of the Milky Way, but have hitherto been ...

journal_title：Nature

authors： Schödel R,Ott T,Genzel R,Hofmann R,Lehnert M,Eckart A,Mouawad N,Alexander T,Reid MJ,Lenzen R,Hartung M,Lacombe F,Rouan D,Gendron E,Rousset G,Lagrange AM,Brandner W,Ageorges N,Lidman C,Moorwood AF,Spyromilio J,Hu

更新日期：2002-10-17 00:00:00

abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...

journal_title：Nature

authors： Krot AN,Yurimoto H,Hutcheon ID,MacPherson GJ

更新日期：2005-04-21 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...

journal_title：Nature

authors： Knutson HA,Charbonneau D,Allen LE,Fortney JJ,Agol E,Cowan NB,Showman AP,Cooper CS,Megeath ST

更新日期：2007-05-10 00:00:00

abstract：:Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β peptide drives cerebral neuroinflammation by activating microglia. Indeed, amyloid-β activation of the NLRP3 inflammasome in microglia is fundamental for interleukin-1β maturation and subsequent inflammatory events. However, it r...

journal_title：Nature

authors： Heneka MT,Kummer MP,Stutz A,Delekate A,Schwartz S,Vieira-Saecker A,Griep A,Axt D,Remus A,Tzeng TC,Gelpi E,Halle A,Korte M,Latz E,Golenbock DT

更新日期：2013-01-31 00:00:00

abstract：:Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...

journal_title：Nature

authors： Chen DF,Schneider GE,Martinou JC,Tonegawa S

更新日期：1997-01-30 00:00:00