Abstract：
:Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, most RGCs from older animals fail to extend axons into CNS tissue derived from donors of any age, including the embryonic tectum. Here we report that the proto-oncogene bcl-2 plays a key role in this developmental change by promoting the growth and regeneration of retinal axons. This effect does not seem to be an indirect consequence of its well-known anti-apoptotic activity. Another anti-apoptotic drug, ZVAD, supported neuronal survival but did not promote axon regeneration in culture. This finding could lead to new strategies for the treatment of injuries to the CNS.
journal_name
Naturejournal_title
Natureauthors
Chen DF,Schneider GE,Martinou JC,Tonegawa Sdoi
10.1038/385434a0subject
Has Abstractpub_date
1997-01-30 00:00:00pages
434-9issue
6615eissn
0028-0836issn
1476-4687journal_volume
385pub_type
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